Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye

2006 ◽  
Vol 83 (3) ◽  
pp. 526-535 ◽  
Author(s):  
Cintia S. De Paiva ◽  
Rosa M. Corrales ◽  
Arturo L. Villarreal ◽  
William J. Farley ◽  
De-Quan Li ◽  
...  
Keyword(s):  
Dry Eye ◽  
Corneal Epithelium ◽  
Inflammatory Cytokine ◽  
Cytokine Expression ◽  
Mapk Activation

scholarly journals Sleep Deprivation Induces Dry Eye Through Inhibition of PPARα Expression in Corneal Epithelium

2018 ◽  
Vol 59 (13) ◽  
pp. 5494 ◽  
Author(s):  
Liying Tang ◽  
Xue Wang ◽  
Jieli Wu ◽  
San Ming Li ◽  
Zhaoqiang Zhang ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Dry Eye ◽  
Corneal Epithelium

Abdominal irradiation increases inflammatory cytokine expression and activates NF-κB in rat ileal muscularis layer

2003 ◽  
Vol 285 (3) ◽  
pp. G556-G565 ◽  
Author(s):  
C. Linard ◽  
A. Ropenga ◽  
M. C. Vozenin-Brotons ◽  
A. Chapel ◽  
D. Mathe
Keyword(s):  
Inflammatory Cytokine ◽  
Intestinal Inflammation ◽  
Clinical Symptoms ◽  
Early Stage ◽  
Cytokine Expression ◽  
Mrna Levels ◽  
Activator Protein 1 ◽  
Γ Irradiation ◽  
Control Tissue ◽  
Anti Inflammatory

The small bowel is an important dose-limiting organ in abdominal radiotherapy because irradiation can cause acute enteritis that, in turn, leads to progressively reduced motility and finally, in a later phase, to fibrosis. Because these clinical symptoms may be caused by the early stage of an inflammatory process, we characterized the radiation-induced intestinal inflammation in rats. Abdominal γ-irradiation (10-Gy) induced a cascade of inflammatory events characterized by an early (6 h after exposure) increase in IL-1β, TNF-α, and IL-6 mRNA levels in the rat ileal muscularis layer. IL-8 [a cytokine-induced neutrophil chemoattractant (CINC)] mRNA appeared later (at 3 days). The expression of TGF-β (a profibrotic cytokine) was higher in irradiated than control tissue at day 1, whereas IL-10 (an anti-inflammatory cytokine) expression vanished completely. Despite strong IL-1ra expression, the IL-1ra/IL-1β ratio, which is an indicator of inflammatory balance, was -41% at day 1 in irradiated compared with control tissue. The nuclear transcription factors NF-κB and activator protein-1 (AP-1) govern transcription of these genes, directly or indirectly. Although expression of the subunits of NF-κB (p65, p50) and AP-1 (c- fos, c- jun) did not increase, irradiation caused a rapid and persistent translocation of p65 and p50. An imbalance between proinflammatory and anti-inflammatory mediators may contribute to perpetuating intestinal inflammation, thus making it chronic.

scholarly journals Kefir reduces insulin resistance and inflammatory cytokine expression in an animal model of metabolic syndrome

2016 ◽  
Vol 7 (8) ◽  
pp. 3390-3401 ◽  
Author(s):  
Damiana D. Rosa ◽  
Łukasz M. Grześkowiak ◽  
Célia L. L. F. Ferreira ◽  
Ana Carolina M. Fonseca ◽  
Sandra A. Reis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Animal Model ◽  
Inflammatory Cytokine ◽  
Fasting Glucose ◽  
Cytokine Expression ◽  
Fasting Insulin ◽  
Insulin Levels ◽  
Reduce Insulin Resistance

Kefir supplementation in rats with induced metabolic syndrome was able to lower fasting glucose, fasting insulin levels, and reduce insulin resistance.

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