scholarly journals Role of Glial Cells in Regulating Retinal Blood Flow During Flicker-Induced Hyperemia in Cats

2015 ◽  
Vol 56 (12) ◽  
pp. 7551 ◽  
Author(s):  
Youngseok Song ◽  
Taiji Nagaoka ◽  
Takafumi Yoshioka ◽  
Seigo Nakabayashi ◽  
Tomofumi Tani ◽  
...  
2008 ◽  
Vol 49 (10) ◽  
pp. 4595 ◽  
Author(s):  
Naohiro Izumi ◽  
Taiji Nagaoka ◽  
Eiichi Sato ◽  
Kenji Sogawa ◽  
Hiroyuki Kagokawa ◽  
...  

2013 ◽  
Vol 33 (11) ◽  
pp. 1685-1695 ◽  
Author(s):  
Eric A Newman

The retinal vasculature supplies cells of the inner and middle layers of the retina with oxygen and nutrients. Photic stimulation dilates retinal arterioles producing blood flow increases, a response termed functional hyperemia. Despite recent advances, the neurovascular coupling mechanisms mediating the functional hyperemia response in the retina remain unclear. In this review, the retinal functional hyperemia response is described, and the cellular mechanisms that may mediate the response are assessed. These neurovascular coupling mechanisms include neuronal stimulation of glial cells, leading to the release of vasoactive arachidonic acid metabolites onto blood vessels, release of potassium from glial cells onto vessels, and production and release of nitric oxide (NO), lactate, and adenosine from neurons and glia. The modulation of neurovascular coupling by oxygen and NO are described, and changes in functional hyperemia that occur with aging and in diabetic retinopathy, glaucoma, and other pathologies, are reviewed. Finally, outstanding questions concerning retinal blood flow in health and disease are discussed.


1999 ◽  
Vol 15 (4) ◽  
pp. 295-303 ◽  
Author(s):  
SEIYO HARINO ◽  
KAZUO NISHIMURA ◽  
KUNIKO KITANISHI ◽  
MINA SUZUKI ◽  
PETER REINACH

1978 ◽  
Vol 26 (6) ◽  
pp. 687-697 ◽  
Author(s):  
C. Pournaras ◽  
M. Tsacopoulos ◽  
Ph. Chapuis

2017 ◽  
Vol 95 (8) ◽  
pp. e794-e795 ◽  
Author(s):  
Lauren Ciulla ◽  
Alon Harris ◽  
June Geng ◽  
Colin Ip ◽  
Patrick Serrano ◽  
...  

2015 ◽  
Vol 56 (5) ◽  
pp. 3113 ◽  
Author(s):  
Takafumi Yoshioka ◽  
Taiji Nagaoka ◽  
Youngseok Song ◽  
Harumasa Yokota ◽  
Tomofumi Tani ◽  
...  

2003 ◽  
Vol 44 (11) ◽  
pp. 4947 ◽  
Author(s):  
Eiichi Sato ◽  
Takashi Sakamoto ◽  
Taiji Nagaoka ◽  
Fumihiko Mori ◽  
Kaoru Takakusaki ◽  
...  

Diabetes ◽  
1990 ◽  
Vol 39 (5) ◽  
pp. 602-607 ◽  
Author(s):  
J. E. Grunwald ◽  
A. J. Brucker ◽  
S. S. Schwartz ◽  
S. N. Braunstein ◽  
L. Baker ◽  
...  

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