scholarly journals The role of hypertension in retinal blood flow alterations in open-angle glaucoma patients

2017 ◽  
Vol 95 (8) ◽  
pp. e794-e795 ◽  
Author(s):  
Lauren Ciulla ◽  
Alon Harris ◽  
June Geng ◽  
Colin Ip ◽  
Patrick Serrano ◽  
...  
Keyword(s):  
Blood Flow ◽  
Open Angle Glaucoma ◽  
Retinal Blood Flow ◽  
Open Angle

Retinal Blood Flow and Nerve Fiber Layer Measurements in Early-Stage Open-Angle Glaucoma

2008 ◽  
Vol 146 (3) ◽  
pp. 466-472.e2 ◽  
Author(s):  
Fatmire Berisha ◽  
Gilbert T. Feke ◽  
Tatsuo Hirose ◽  
J. Wallace McMeel ◽  
Louis R. Pasquale
Keyword(s):  
Blood Flow ◽  
Nerve Fiber ◽  
Early Stage ◽  
Open Angle Glaucoma ◽  
Retinal Blood Flow ◽  
Open Angle ◽  
Fiber Layer ◽  
Nerve Fiber Layer

Association of Visual Field Severity and Parapapillary Retinal Blood Flow in Open-Angle Glaucoma

2009 ◽  
pp. 1 ◽  
Author(s):  
Sunil Deokule ◽  
Gianmarco Vizzeri ◽  
Andreas Boehm ◽  
Christopher Bowd ◽  
Robert N. Weinreb
Keyword(s):  
Blood Flow ◽  
Visual Field ◽  
Open Angle Glaucoma ◽  
Retinal Blood Flow ◽  
Open Angle

The Influence of Retinal Blood Flow on Open-angle Glaucoma in Patients with and without Diabetes

2014 ◽  
Vol 24 (4) ◽  
pp. 542-549 ◽  
Author(s):  
Eric Lee ◽  
Alon Harris ◽  
Brent Siesky ◽  
Tara Schaab ◽  
Nathaniel McIntyre ◽  
...  
Keyword(s):  
Blood Flow ◽  
Open Angle Glaucoma ◽  
Retinal Blood Flow ◽  
Open Angle

scholarly journals Effect of 2% dorzolamide on retinal blood flow: a study on juvenile primary open-angle glaucoma patients already receiving 0.5% timolol

2007 ◽  
Vol 63 (3) ◽  
pp. 376-379 ◽  
Author(s):  
Ciro Costagliola ◽  
Claudio Campa ◽  
Francesco Parmeggiani ◽  
Carlo Incorvaia ◽  
Paolo Perri ◽  
...  
Keyword(s):  
Blood Flow ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Blood Flow ◽  
Open Angle

Relationship Between Macular Vessel Density and Total Retinal Blood Flow in Primary Open-angle Glaucoma

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jennifer Cano ◽  
Mansour Rahimi ◽  
Benjamin Y. Xu ◽  
Grace M. Richter ◽  
Ou Tan ◽  
...  
Keyword(s):  
Blood Flow ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Vessel Density ◽  
Retinal Blood Flow ◽  
Open Angle

scholarly journals OCT angiography analysis of retinal vessel density in primary open-angle glaucoma with and without Tafluprost therapy

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hannah Weindler ◽  
Martin S. Spitzer ◽  
Maximilian Schultheiß ◽  
Robert Kromer
Keyword(s):  
Blood Flow ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Vessel ◽  
Vessel Density ◽  
Retinal Blood Flow ◽  
Flow Density ◽  
Open Angle ◽  
Post Surgery ◽  
Retinal Vessel Density

Abstract Background Primary open-angle glaucoma (POAG) is a progressive neurodegenerative disease which leads to irreversible blindness. An elevated intraocular pressure (IOP) is considered to be the main risk factor for the disease progression. It is known that retinal blood flow is altered in POAG eyes. Tafluprost, a prostaglandin analogue which lowers the IOP, has shown to also improve the retinal blood flow in animals. Methods The current study therefore evaluated the retinal vessel density in the peripapillary and macular region of POAG patients with normal IOP treated with topical Tafluprost (n = 20) compared to surgically treated patients with normal IOP (n = 22) using optical coherence tomography angiography (OCT-A). The retinal flow density was obtained after binarisation and evaluated in five sectors. Results There was a significantly higher peripapillary flow density in all sectors in Tafluprost treated eyes when compared to post-surgery eyes. The flow density in the inferior sector of the superficial plexus in the macular region was also significantly higher in the Tafluprost group. Conclusions: These results indicate that Tafluprost not only lowers IOP, but may also enhance retinal blood flow in POAG patients with a normal IOP.

Effect of Brimonidine on Retinal Blood Flow Autoregulation in Primary Open-Angle Glaucoma

2011 ◽  
Vol 27 (4) ◽  
pp. 347-352 ◽  
Author(s):  
Gilbert T. Feke ◽  
Ribhi Hazin ◽  
Cynthia L. Grosskreutz ◽  
Louis R. Pasquale
Keyword(s):  
Blood Flow ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Blood Flow ◽  
Open Angle

The role of matrix metalloproteinase 9 and its inhibitors in scarring processes following surgery for primary open-angle glaucoma

2019 ◽  
pp. 72-80
Author(s):  
Е.В. Маркелова ◽  
О.В. Овчинникова ◽  
А.С. Хохлова ◽  
Л.П. Догадова ◽  
А.В. Костюшко ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Postoperative Period ◽  
Open Angle Glaucoma ◽  
Matrix Metalloproteinase 9 ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Open Angle ◽  
Tissue Inhibitors ◽  
Surgery Outcome ◽  
Metalloproteinase 9

Оперативное вмешательство - один из основных методов лечения глаукомы. Однако развитие избыточного рубцевания созданных путей оттока определяет результат хирургического лечения в отдаленные сроки. Процессы рубцевания на данный момент недостаточно изучены. Цель исследования - оценка роли матриксной металлопротеиназы-9, ее ингибиторов в процессах рубцевания у больных с первичной открытоугольной глаукомой после оперативного лечения. Методика. Для выявления возможных маркеров избыточного рубцевания методом твердофазного иммуноферментного анализа определяли содержание матриксных металлопротеиназ-9, тканевых ингибиторов металлопротеиназ 2 и -3 в слезной жидкости у 37 пациентов с активной стадией первичной остроугольной глаукомы в динамике послеоперационного периода. Средний возраст пациентов составил 52,8 лет. В зависимости от исхода оперативного вмешательства все пациенты были разделены на 2 группы - с благоприятным исходом (без избыточного рубцевания) и с неблагоприятным исходом (с избыточным рубцеванием) на месте сформированных дополнительных путей оттока внутриглазной жидкости в послеоперационном периоде. Группа контроля включала 20 человек в возрасте от 50 до 66 лет без сопутствующей офтальмологической и соматической патологии в стадии обострения. Результаты. В динамике показано изменение концентрации матриксной металлопротеиназы-9 и ее ингибиторов в послеоперационном периоде. Анализ данных свидетельствует об обратной зависимости уровня матриксной металлопротеиназы-9 и тканевых ингибиторов металлопротеиназы 2 и 3 типов с исходом операции - чем выше концентрация металлопротеиназы-9 и ниже концентрация тканевых ингибиторов металлопротеиназ 2, -3 в слезной жидкости, тем выше вероятность неблагоприятного исхода в виде рубцевания сформированных дополнительных путей оттока внутриглазной жидкости в послеоперационном периоде. Заключение. Мониторинг уровня металлопротеиназ и их тканевых ингибиторов после проведения хирургического лечения пациентов с первичной открытоугольной глаукомой позволяет прогнозировать раннее рубцевание, дает возможность разработки новых методов лечения как в раннем, так и в позднем послеоперационном периоде. Surgery is one of the major treatments for glaucoma; however excessive scarring of created outflow patways affects the long-term outcome. At the present time, scarring processes are not sufficiently studied. Aim. To evaluate the role of matrix metalloproteinase 9 and its inhibitors in scarring after surgical treatment of open-angle glaucoma. Methods. Concentrations of matrix metalloproteinase 9 and tissue inhibitors of metalloproteinases 2 and 3 were measured in tear fluid of 37 patients (mean age, 52.8) with active primary open-angle glaucoma in dynamics during the postoperative period to identify possible markers of excessive scarring. Based on the surgery outcome, all patients were divided into two groups, with a favorable outcome (without excessive scarring) and an unfavorable outcome (with excessive scarring) in the created additional outflow pathways for the intraocular fluid in the postoperative period. The control group included 20 subjects aged 50-66 without eye disease or somatic disease at exacerbation stage. Results. Analysis of changes in concentrations of matrix metalloproteinase 9 and its inhibitors in the postoperative period showed their inverse relationship with the surgery outcome. The higher was the metalloproteinase 9 level and the lower the level of tissue inhibitors of metalloproteinases 2 and 3 the higher was the probability of unfavorable outcome evident as excessive scarring of the formed additional pathways for tear fluid outflow in the postoperative period. Conclusion. Postoperative monitoring of metalloproteinases and their tissue inhibitors allows to predict early scarring and to develop new treatments both in early and late postoperative periods.

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