The Role of a Glycoprotein K (gK) CD8+T-Cell Epitope of Herpes Simplex Virus on Virus Replication and Pathogenicity

2009 ◽  
Vol 50 (6) ◽  
pp. 2903 ◽  
Author(s):  
Kevin R. Mott ◽  
Aziz A. Chentoufi ◽  
Dale Carpenter ◽  
Lbachir BenMohamed ◽  
Steven L. Wechsler ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Replication ◽  
Cell Epitope ◽  
Cd8 T Cell ◽  
T Cell Epitope ◽  
Glycoprotein K ◽  
Simplex Virus

Stepwise identification of HLA-A*0201-restricted CD8+ T-cell epitope peptides from herpes simplex virus type 1 genome boosted by a steprank scheme

Biopolymers ◽  
2010 ◽  
Vol 96 (3) ◽  
pp. 328-339 ◽  
Author(s):  
Jianjun Bi ◽  
Rengang Song ◽  
Huilan Yang ◽  
Bingling Li ◽  
Jianyong Fan ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cell Epitope ◽  
Cd8 T Cell ◽  
T Cell Epitope ◽  
Simplex Virus

scholarly journals Influence of an immunodominant herpes simplex virus type 1 CD8+ T cell epitope on the target hierarchy and function of subdominant CD8+ T cells

2017 ◽  
Vol 13 (12) ◽  
pp. e1006732 ◽  
Author(s):  
Benjamin R. Treat ◽  
Sarah M. Bidula ◽  
Srividya Ramachandran ◽  
Anthony J. St Leger ◽  
Robert L. Hendricks ◽  
...  
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cd8 T Cells ◽  
Cell Epitope ◽  
Cd8 T Cell ◽  
T Cell Epitope ◽  
Simplex Virus ◽  
And Function

scholarly journals The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1

2011 ◽  
Vol 85 (9) ◽  
pp. 4184-4197 ◽  
Author(s):  
S. J. Allen ◽  
P. Hamrah ◽  
D. Gate ◽  
K. R. Mott ◽  
D. Mantopoulos ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Cd8 T Cell ◽  
Trigeminal Ganglia ◽  
Herpes Simplex Virus 1 ◽  
Cell Exhaustion ◽  
Latently Infected ◽  
Simplex Virus

The role of the UL41 gene of herpes simplex virus type 1 in evasion of non-specific host defence mechanisms during primary infection

Microbiology ◽  
2000 ◽  
Vol 81 (7) ◽  
pp. 1763-1771 ◽  
Author(s):  
Tatsuo Suzutani ◽  
Masayoshi Nagamine ◽  
Taiichiro Shibaki ◽  
Masahiro Ogasawara ◽  
Itsuro Yoshida ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Replication ◽  
Primary Infection ◽  
Interferon Α ◽  
Defence Mechanisms ◽  
Specific Host ◽  
Γ Ray ◽  
Simplex Virus

The UL41 gene product (vhs) of herpes simplex virus (HSV) is packaged in the virion, and mediates host protein synthesis shutoff at the early stage of the virus replication cycle. In order to clarify the role of vhs in virus replication and virulence, we isolated a completely UL41-deficient mutant (the VRΔ41 strain) and its revertant (the VRΔ41R strain). In the mouse encephalitis model, the replication of strain VRΔ41 was inhibited after 2 days post-infection, resulting in low virulence, by γ-ray-sensitive cells such as lymphocytes and/or neutrophils. The result suggested that some cytokines, produced in VRΔ41-inoculated brains, activate and induce the migration of γ-ray-sensitive cells to the infection site. Therefore, cytokines produced by HSV-1-infected human cells were screened, and potent inductions of interleukin (IL)-1β, IL-8 and macrophage inflammatory protein-1α by VRΔ41 infection were observed. Moreover, the VRΔ41 strain showed 20- and 5-fold higher sensitivity to interferon-α and -β compared to the wild-type strain, respectively. These results indicate that one important role of vhs in vivo is evasion from non-specific host defence mechanisms during primary infection through suppression of cytokine production in HSV-infected cells and reduction of the anti-HSV activity of interferon-α and -β.

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