scholarly journals The Effect of Adjuvanting Cancer Vaccines with Herpes Simplex Virus Glycoprotein D on Melanoma-Driven CD8+T Cell Exhaustion

2014 ◽  
Vol 193 (4) ◽  
pp. 1836-1846 ◽  
Author(s):  
Ying Zhang ◽  
Hildegund C. J. Ertl
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Cancer Vaccines ◽  
Cd8 T Cell ◽  
Glycoprotein D ◽  
Cell Exhaustion ◽  
Virus Glycoprotein ◽  
Herpes Simplex Virus Glycoprotein ◽  
Simplex Virus

scholarly journals Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor HveA

2001 ◽  
Vol 8 (1) ◽  
pp. 169-179 ◽  
Author(s):  
Andrea Carfı́ ◽  
Sharon H. Willis ◽  
J.Charles Whitbeck ◽  
Claude Krummenacher ◽  
Gary H. Cohen ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Glycoprotein D ◽  
Virus Glycoprotein ◽  
Herpes Simplex Virus Glycoprotein ◽  
Simplex Virus ◽  
Human Receptor

scholarly journals Identification of Novel Immunodominant CD4+ Th1-Type T-Cell Peptide Epitopes from Herpes Simplex Virus Glycoprotein D That Confer Protective Immunity

2003 ◽  
Vol 77 (17) ◽  
pp. 9463-9473 ◽  
Author(s):  
Lbachir BenMohamed ◽  
Georges Bertrand ◽  
Cory D. McNamara ◽  
Helene Gras-Masse ◽  
Juergen Hammer ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Protective Immunity ◽  
Biologically Active ◽  
Glycoprotein D ◽  
Peptide Epitopes ◽  
Herpes Simplex Virus Glycoprotein ◽  
Simplex Virus ◽  
Hsv 1

ABSTRACT The molecular characterization of the epitope repertoire on herpes simplex virus (HSV) antigens would greatly expand our knowledge of HSV immunity and improve immune interventions against herpesvirus infections. HSV glycoprotein D (gD) is an immunodominant viral coat protein and is considered an excellent vaccine candidate antigen. By using the TEPITOPE prediction algorithm, we have identified and characterized a total of 12 regions within the HSV type 1 (HSV-1) gD bearing potential CD4+ T-cell epitopes, each 27 to 34 amino acids in length. Immunogenicity studies of the corresponding medium-sized peptides confirmed all previously known gD epitopes and additionally revealed four new immunodominant regions (gD49-82, gD146-179, gD228-257, and gD332-358), each containing naturally processed epitopes. These epitopes elicited potent T-cell responses in mice of diverse major histocompatibility complex backgrounds. Each of the four new immunodominant peptide epitopes generated strong CD4+ Th1 T cells that were biologically active against HSV-1-infected bone marrow-derived dendritic cells. Importantly, immunization of H-2d mice with the four newly identified CD4+ Th1 peptide epitopes but not with four CD4+ Th2 peptide epitopes induced a robust protective immunity against lethal ocular HSV-1 challenge. These peptide epitopes may prove to be important components of an effective immunoprophylactic strategy against herpes.

scholarly journals Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1

2011 ◽  
Vol 7 (9) ◽  
pp. e1002277 ◽  
Author(s):  
Paolo Di Giovine ◽  
Ethan C. Settembre ◽  
Arjun K. Bhargava ◽  
Micah A. Luftig ◽  
Huan Lou ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Glycoprotein D ◽  
Virus Glycoprotein ◽  
Herpes Simplex Virus Glycoprotein ◽  
Simplex Virus ◽  
Human Receptor
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