Either a CD4+or CD8+T cell function is sufficient for clearance of infectious virus from trigeminal ganglia and establishment of herpes simplex virus type 1 latency in mice

1999 ◽  
Vol 27 (6) ◽  
pp. 387-394 ◽  
Author(s):  
Homayon Ghiasi ◽  
Guey -Chuen Perng ◽  
Anthony B Nesburn ◽  
Steven L Wechsler
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Herpes Simplex Virus Type ◽  
Infectious Virus ◽  
Cell Function ◽  
Cd8 T Cell ◽  
Trigeminal Ganglia ◽  
Simplex Virus

scholarly journals Psychological Stress Compromises CD8+T Cell Control of Latent Herpes Simplex Virus Type 1 Infections

2007 ◽  
Vol 179 (1) ◽  
pp. 322-328 ◽  
Author(s):  
Michael L. Freeman ◽  
Brian S. Sheridan ◽  
Robert H. Bonneau ◽  
Robert L. Hendricks
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Psychological Stress ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cd8 T Cell ◽  
Cell Control ◽  
Simplex Virus

scholarly journals CD8+ T cells control corneal disease following ocular infection with herpes simplex virus type 1

2004 ◽  
Vol 85 (7) ◽  
pp. 2055-2063 ◽  
Author(s):  
Patrick M. Stuart ◽  
Brett Summers ◽  
Jessica E. Morris ◽  
Lynda A. Morrison ◽  
David A. Leib
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Herpes Simplex Virus Type ◽  
T Cell Subsets ◽  
Trigeminal Ganglia ◽  
Corneal Disease ◽  
Simplex Virus

The role that T cell subsets play in herpetic stromal keratitis (HSK) has been the subject of intense research efforts. While most studies implicate CD4+ T cells as the principal cell type mediating primary corneal disease, recent reports using knockout mice have suggested that both CD4+ and CD8+ T cell subsets may play integral roles in modulating the disease. Furthermore, recent studies suggest that CD8+ T cells are directly involved in maintaining virus latency in infected trigeminal ganglia. This work has addressed these discrepancies by infecting the corneas of mice lacking CD4+ and CD8+ T cells with herpes simplex virus type 1 (HSV-1) and monitoring both corneal disease and latent infection of trigeminal ganglia. Results indicated that mice lacking CD8+ T cells had more severe corneal disease than either BALB/c or B6 parental strains. In contrast, mice lacking CD4+ T cells had a milder disease than parental strains. When mice were evaluated for persistence of infectious virus, only transient differences were observed in periocular tissue and corneas. No significant differences were found in persistence of virus in trigeminal ganglia or virus reactivation from explanted ganglia. These data support the following conclusions. CD4+ T cells are not required for resistance to infection with HSV-1 and probably mediate HSK. Mice lacking CD8+ T cells do not display differences in viral loads or reactivation and thus CD8+ T cells are not absolutely required to maintain latency. Finally, CD8+ T cells probably play a protective role by regulating the immunopathological response that mediates HSK.

scholarly journals Upregulation of Multiple CD8+ T Cell Exhaustion Pathways Is Associated with Recurrent Ocular Herpes Simplex Virus Type 1 Infection

2020 ◽  
Vol 205 (2) ◽  
pp. 454-468
Author(s):  
Pierre-Grégoire Coulon ◽  
Soumyabrata Roy ◽  
Swayam Prakash ◽  
Ruchi Srivastava ◽  
Nisha Dhanushkodi ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cd8 T Cell ◽  
Cell Exhaustion ◽  
Ocular Herpes ◽  
Simplex Virus

scholarly journals Cutting Edge: Priming of CD8 T Cell Immunity to Herpes Simplex Virus Type 1 Requires Cognate TLR3 Expression InVivo

2010 ◽  
Vol 184 (5) ◽  
pp. 2243-2246 ◽  
Author(s):  
Gayle M. Davey ◽  
Magdalena Wojtasiak ◽  
Anna I. Proietto ◽  
Francis R. Carbone ◽  
William R. Heath ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Cell Immunity ◽  
Simplex Virus

Stepwise identification of HLA-A*0201-restricted CD8+ T-cell epitope peptides from herpes simplex virus type 1 genome boosted by a steprank scheme

Biopolymers ◽  
2010 ◽  
Vol 96 (3) ◽  
pp. 328-339 ◽  
Author(s):  
Jianjun Bi ◽  
Rengang Song ◽  
Huilan Yang ◽  
Bingling Li ◽  
Jianyong Fan ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cell Epitope ◽  
Cd8 T Cell ◽  
T Cell Epitope ◽  
Simplex Virus

scholarly journals Medroxyprogesterone Acetate Inhibits CD8+T Cell Viral-Specific Effector Function and Induces Herpes Simplex Virus Type 1 Reactivation

2008 ◽  
Vol 181 (2) ◽  
pp. 969-975 ◽  
Author(s):  
Thomas L. Cherpes ◽  
James L. Busch ◽  
Brian S. Sheridan ◽  
Stephen A. K. Harvey ◽  
Robert L. Hendricks
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Medroxyprogesterone Acetate ◽  
Cd8 T Cell ◽  
Specific Effector ◽  
Simplex Virus
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