scholarly journals Novel Hyaluronic Acid-Chitosan Nanoparticles for Ocular Gene Therapy

2008 ◽  
Vol 49 (5) ◽  
pp. 2016 ◽  
Author(s):  
Maria de la Fuente ◽  
Begon~a Seijo ◽  
Maria J. Alonso
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Chitosan Nanoparticles

scholarly journals Photocuring Hyaluronic Acid/Silk Fibroin Hydrogel Containing Curcumin Loaded CHITOSAN Nanoparticles for the Treatment of MG-63 Cells and ME3T3-E1 Cells

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2302
Author(s):  
Qingwen Yu ◽  
Zhiyuan Meng ◽  
Yichao Liu ◽  
Zehao Li ◽  
Xing Sun ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Bone Regeneration ◽  
Water Uptake ◽  
Silk Fibroin ◽  
Bone Repair ◽  
Ph Value ◽  
Chitosan Nanoparticles ◽  
Vitro Assay ◽  
Long Term Treatment

After an osteosarcoma excision, recurrence and bone defects are significant challenges for clinicians. In this study, the curcumin (Cur) loaded chitosan (CS) nanoparticles (CCNP) encapsulated silk fibroin (SF)/hyaluronic acid esterified by methacrylate (HAMA) (CCNPs-SF/HAMA) hydrogel for the osteosarcoma therapy and bone regeneration was developed by photocuring and ethanol treatment. The micro or nanofibers networks were observed in the CCNPs-SF/HAMA hydrogel. The FTIR results demonstrated that alcohol vapor treatment caused an increase in β-sheets of SF, resulting in the high compression stress and Young’s modulus of CCNPs-SF/HAMA hydrogel. According to the water uptake analysis, SF caused a slight decrease in water uptake of CCNPs-SF/HAMA hydrogel while CCNPs could enhance the water uptake of it. The swelling kinetic results showed that both the CCNPs and the SF increased the swelling ratio of CCNPs-SF/HAMA hydrogel. The accumulative release profile of CCNPs-SF/HAMA hydrogel showed that the release of Cur from CCNPs-SF/HAMA hydrogel was accelerated when pH value was decreased from 7.4 to 5.5. Besides, compared with CCNPs, the CCNPs-SF/HAMA hydrogel had a more sustainable drug release, which was beneficial for the long-term treatment of osteosarcoma. In vitro assay results indicated that CCNPs-SF/HAMA hydrogel with equivalent Cur concentration of 150 μg/mL possessed both the effect of anti-cancer and promoting the proliferation of osteoblasts. These results suggest that CCNPs-SF/HAMA hydrogel with superior physical properties and the bifunctional osteosarcoma therapy and bone repair may be an excellent candidate for local cancer therapy and bone regeneration.

scholarly journals DNA‐Grafted Hyaluronic Acid System with Enhanced Injectability and Biostability for Photo‐Controlled Osteoarthritis Gene Therapy

2021 ◽  
pp. 2004793
Author(s):  
Zhijie Chen ◽  
Feng Zhang ◽  
Hongbo Zhang ◽  
Liang Cheng ◽  
Kaizhe Chen ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Acid System

scholarly journals Hyaluronic Acid Coated Chitosan Nanoparticles Reduced the Immunogenicity of the Formed Protein Corona

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Abdulaziz Almalik ◽  
Hicham Benabdelkamel ◽  
Afshan Masood ◽  
Ibrahim O. Alanazi ◽  
Ibrahim Alradwan ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Chitosan Nanoparticles ◽  
Protein Corona

A novel gene therapy vector based on hyaluronic acid and solid lipid nanoparticles for ocular diseases

2014 ◽  
Vol 465 (1-2) ◽  
pp. 413-426 ◽  
Author(s):  
Paola Stephanie Apaolaza ◽  
Diego Delgado ◽  
Ana del Pozo-Rodríguez ◽  
Alicia Rodríguez Gascón ◽  
M.Ángeles Solinís
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Ocular Diseases ◽  
Gene Therapy Vector ◽  
Solid Lipid ◽  
Novel Gene

scholarly journals Hyaluronic Acid-Chitosan Nanoparticles to Deliver Gd-DTPA for MR Cancer Imaging

Nanomaterials ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. 1379-1396 ◽  
Author(s):  
Li Zhang ◽  
Tingxian Liu ◽  
Yanan Xiao ◽  
Dexin Yu ◽  
Na Zhang
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Imaging ◽  
Chitosan Nanoparticles

scholarly journals Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy

2017 ◽  
Vol 103 ◽  
pp. 27-35 ◽  
Author(s):  
Thomas F Martens ◽  
Karen Peynshaert ◽  
Thaís Leite Nascimento ◽  
Elias Fattal ◽  
Marcus Karlstetter ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Intravitreal Drug Delivery ◽  
Retinal Gene Therapy ◽  
Hyaluronic Acid Binding
Sign in / Sign up

Export Citation Format

Share Document