scholarly journals DNA‐Grafted Hyaluronic Acid System with Enhanced Injectability and Biostability for Photo‐Controlled Osteoarthritis Gene Therapy

2021 ◽  
pp. 2004793
Author(s):  
Zhijie Chen ◽  
Feng Zhang ◽  
Hongbo Zhang ◽  
Liang Cheng ◽  
Kaizhe Chen ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Acid System

Changes in the hyaluronidase-hyaluronic acid system in the kidneys of rabbits with experimental intestitial nephritis

1964 ◽  
Vol 57 (3) ◽  
pp. 277-281
Author(s):  
A. G. Ginetsinskii ◽  
M. G. Zaks ◽  
V. I. Ioffe ◽  
T. V. Krestinskaya ◽  
M. M. Sokolova ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Acid System

A novel gene therapy vector based on hyaluronic acid and solid lipid nanoparticles for ocular diseases

2014 ◽  
Vol 465 (1-2) ◽  
pp. 413-426 ◽  
Author(s):  
Paola Stephanie Apaolaza ◽  
Diego Delgado ◽  
Ana del Pozo-Rodríguez ◽  
Alicia Rodríguez Gascón ◽  
M.Ángeles Solinís
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Ocular Diseases ◽  
Gene Therapy Vector ◽  
Solid Lipid ◽  
Novel Gene

scholarly journals Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy

2017 ◽  
Vol 103 ◽  
pp. 27-35 ◽  
Author(s):  
Thomas F Martens ◽  
Karen Peynshaert ◽  
Thaís Leite Nascimento ◽  
Elias Fattal ◽  
Marcus Karlstetter ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Intravitreal Drug Delivery ◽  
Retinal Gene Therapy ◽  
Hyaluronic Acid Binding

scholarly journals Novel Hyaluronic Acid-Chitosan Nanoparticles for Ocular Gene Therapy

2008 ◽  
Vol 49 (5) ◽  
pp. 2016 ◽  
Author(s):  
Maria de la Fuente ◽  
Begon~a Seijo ◽  
Maria J. Alonso
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Chitosan Nanoparticles

Effect of vegf gene therapy and hyaluronic acid film sheath on peripheral nerve regeneration

Microsurgery ◽  
2013 ◽  
Vol 34 (3) ◽  
pp. 209-216 ◽  
Author(s):  
Fatih Zor ◽  
Mustafa Deveci ◽  
Abdullah Kilic ◽  
Mehmet Fatih Ozdag ◽  
Bulent Kurt ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Vegf Gene

Hyaluronic Acid/Chitosan-g-Poly(ethylene glycol) Nanoparticles for Gene Therapy: An Application for pDNA and siRNA Delivery

2010 ◽  
Vol 27 (12) ◽  
pp. 2544-2555 ◽  
Author(s):  
Manuela Raviña ◽  
Eva Cubillo ◽  
David Olmeda ◽  
Ramón Novoa-Carballal ◽  
Eduardo Fernandez-Megia ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Ethylene Glycol ◽  
Sirna Delivery ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Hyaluronic Acid-Based Nanomaterials for Cancer Therapy

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1133 ◽  
Author(s):  
Jin Kim ◽  
Myeong Moon ◽  
Dong Kim ◽  
Suk Heo ◽  
Yong Jeong
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Extracellular Matrix ◽  
Hyaluronic Acid ◽  
Combination Therapy ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Targeted Chemotherapy ◽  
Tumor Initiating Cells ◽  
Good Potential

Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan and a major component of the extracellular matrix. HA is overexpressed by numerous tumor cells, especially tumor-initiating cells. HA-based nanomaterials play in importance role in drug delivery systems. HA is used in various types of nanomaterials including micelle, polymersome, hydrogel, and inorganic nanoparticle formulations. Many experiments show that HA-based nanomaterials can serve as a platform for targeted chemotherapy, gene therapy, immunotherapy, and combination therapy with good potential for future biomedical applications in cancer treatment.

scholarly journals Dual-targeted cationic liposomes modified with hyaluronic acid and folic acid deliver siRNA Bcl-2 in the treatment of cervical cancer

2020 ◽  
Author(s):  
Yao Tong ◽  
Wen-jun Wan ◽  
Han Yang ◽  
Yu Wang ◽  
Dan-dan Wang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Folic Acid ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Genetic Diseases ◽  
Potential Method ◽  
Cationic Liposomes ◽  
Ultrasonic Dispersion ◽  
Targeting Efficiency

Abstract Backgroud: Gene therapy has attracted widespread attention as a potential method of treating some autoimmune diseases, genetic diseases and cancer. It is critical to discover a new nanocarrier for the effectiveness of gene therapy. Reportedly, the dual-targed nano-delivery system as a novel strategy could improve targeting efficiency and deliver more drugs or genes to tumor sites over current single-targed nano-delivery delivery system.Methods: We synthesized and characterized the hyaluronic acid (HA)-folic acid (FA) polymer, and then prepared the cationic liposomes by ultrasonic dispersion . The liposome was coated with HA-FA to obtain HA-FA-Lip nanoparticles. HA-FA-Lip formed complexes with siRNA Bcl-2 (siBcl-2) through electrostatic adsorption for delivering siBcl-2 to the tumor site.Results: HA-FA-Lip showed stronger tumor accumulation and better targeting efficiency than HA-lip. Meanwhile, HA-FA-Lip delivered more siBcl-2 to tumor cells and played a role in down-regulating Bcl protein levels, thus inducing obvious apoptosis.Conclusions: As a new type of dual-targeted drug delivery system, HA-FA-Lip was expected to be an effective nanocarrier with high transfection efficiency and good biocompatibility.

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