scholarly journals Hyaluronic Acid-Chitosan Nanoparticles to Deliver Gd-DTPA for MR Cancer Imaging

Nanomaterials ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. 1379-1396 ◽  
Author(s):  
Li Zhang ◽  
Tingxian Liu ◽  
Yanan Xiao ◽  
Dexin Yu ◽  
Na Zhang
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Imaging ◽  
Chitosan Nanoparticles

scholarly journals Photocuring Hyaluronic Acid/Silk Fibroin Hydrogel Containing Curcumin Loaded CHITOSAN Nanoparticles for the Treatment of MG-63 Cells and ME3T3-E1 Cells

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2302
Author(s):  
Qingwen Yu ◽  
Zhiyuan Meng ◽  
Yichao Liu ◽  
Zehao Li ◽  
Xing Sun ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Bone Regeneration ◽  
Water Uptake ◽  
Silk Fibroin ◽  
Bone Repair ◽  
Ph Value ◽  
Chitosan Nanoparticles ◽  
Vitro Assay ◽  
Long Term Treatment

After an osteosarcoma excision, recurrence and bone defects are significant challenges for clinicians. In this study, the curcumin (Cur) loaded chitosan (CS) nanoparticles (CCNP) encapsulated silk fibroin (SF)/hyaluronic acid esterified by methacrylate (HAMA) (CCNPs-SF/HAMA) hydrogel for the osteosarcoma therapy and bone regeneration was developed by photocuring and ethanol treatment. The micro or nanofibers networks were observed in the CCNPs-SF/HAMA hydrogel. The FTIR results demonstrated that alcohol vapor treatment caused an increase in β-sheets of SF, resulting in the high compression stress and Young’s modulus of CCNPs-SF/HAMA hydrogel. According to the water uptake analysis, SF caused a slight decrease in water uptake of CCNPs-SF/HAMA hydrogel while CCNPs could enhance the water uptake of it. The swelling kinetic results showed that both the CCNPs and the SF increased the swelling ratio of CCNPs-SF/HAMA hydrogel. The accumulative release profile of CCNPs-SF/HAMA hydrogel showed that the release of Cur from CCNPs-SF/HAMA hydrogel was accelerated when pH value was decreased from 7.4 to 5.5. Besides, compared with CCNPs, the CCNPs-SF/HAMA hydrogel had a more sustainable drug release, which was beneficial for the long-term treatment of osteosarcoma. In vitro assay results indicated that CCNPs-SF/HAMA hydrogel with equivalent Cur concentration of 150 μg/mL possessed both the effect of anti-cancer and promoting the proliferation of osteoblasts. These results suggest that CCNPs-SF/HAMA hydrogel with superior physical properties and the bifunctional osteosarcoma therapy and bone repair may be an excellent candidate for local cancer therapy and bone regeneration.

scholarly journals Hyaluronic Acid Coated Chitosan Nanoparticles Reduced the Immunogenicity of the Formed Protein Corona

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Abdulaziz Almalik ◽  
Hicham Benabdelkamel ◽  
Afshan Masood ◽  
Ibrahim O. Alanazi ◽  
Ibrahim Alradwan ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Chitosan Nanoparticles ◽  
Protein Corona

Hyaluronic acid/Chitosan nanoparticles as delivery vehicles for VEGF and PDGF-BB

Drug Delivery ◽  
2010 ◽  
Vol 17 (8) ◽  
pp. 596-604 ◽  
Author(s):  
Yolanda Parajó ◽  
Ivana d’Angelo ◽  
Alexander Welle ◽  
Marcos Garcia-Fuentes ◽  
María José Alonso
Keyword(s):  
Hyaluronic Acid ◽  
Chitosan Nanoparticles ◽  
Delivery Vehicles

scholarly journals Electrospun Fibres with Hyaluronic Acid-Chitosan Nanoparticles Produced by a Portable Device

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2016
Author(s):  
Carla V. Fuenteslópez ◽  
Hua Ye
Keyword(s):  
Cell Proliferation ◽  
Hyaluronic Acid ◽  
Cell Viability ◽  
Cell Attachment ◽  
Chitosan Nanoparticles ◽  
Cell Interaction ◽  
Portable Device ◽  
Growth And Yield ◽  
Directional Growth ◽  
Versatile Technique

Electrospinning is a versatile technique to produce nano/microscale fibrous scaffolds for tissue engineering and drug delivery applications. This research aims to demonstrate that hyaluronic acid-chitosan (HA-CS) nanoparticles can be electrospun together with polycaprolactone (PCL) and gelatine (Ge) fibres using a portable device to create scaffolds for tissue repair. A range of polymer solutions of PCL-gelatine at different weight/volume concentrations and ratios were electrospun and characterised. Fibre–cell interaction (F11 cells) was evaluated based on cell viability and proliferation and, from here, a few polymer blends were electrospun into random or aligned fibre arrangements. HA-CS nanoparticles were synthesised, characterised, and used to functionalise electrospun fibres (8% w/v at 70 PCL:30 Ge), which were chosen based on cell viability. Different concentrations of HA-CS nanoparticles were tested to determine cytotoxicity. A single dosage (1 × 10−2 mg/mL) was associated with higher cell proliferation compared with the cell-only control. This nanoparticle concentration was embedded into the electrospun fibres as either surface modification or blend. Fibres with blended NPs delivered a higher cell viability than unmodified fibres, while NP-coated fibres resulted in a higher cell proliferation (72 h) than the NP-blended ones. These biocompatible scaffolds allow cell attachment, maintain fibre arrangement, promote directional growth and yield higher cell viability.

scholarly journals Biocompatibility of Gd-Loaded Chitosan-Hyaluronic Acid Nanogels as Contrast Agents for Magnetic Resonance Cancer Imaging

Nanomaterials ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 201 ◽  
Author(s):  
Cecilia Gheran ◽  
Guillaume Rigaux ◽  
Maité Callewaert ◽  
Alexandre Berquand ◽  
Michael Molinari ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Cancer Imaging

scholarly journals Novel Hyaluronic Acid-Chitosan Nanoparticles for Ocular Gene Therapy

2008 ◽  
Vol 49 (5) ◽  
pp. 2016 ◽  
Author(s):  
Maria de la Fuente ◽  
Begon~a Seijo ◽  
Maria J. Alonso
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Chitosan Nanoparticles
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