Using Gold Nanoparticles as Delivery Vehicles for Targeted Delivery of Chemotherapy Drug Fludarabine Phosphate to Treat Hematological Cancers

2016 ◽  
Vol 16 (3) ◽  
pp. 2582-2586 ◽  
Author(s):  
Steven Song ◽  
Yuzhi Hao ◽  
Xiaoyan Yang ◽  
Prabir Patra ◽  
Jie Chen
Keyword(s):  
Gold Nanoparticles ◽  
Targeted Delivery ◽  
Chemotherapy Drug ◽  
Fludarabine Phosphate ◽  
Hematological Cancers ◽  
Delivery Vehicles

scholarly journals Gold Nanoparticles in Cancer Theranostics

2021 ◽  
Vol 9 ◽  
Author(s):  
Qinyue Gao ◽  
Jingjing Zhang ◽  
Jie Gao ◽  
Zhengyang Zhang ◽  
Haitao Zhu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Targeted Delivery ◽  
Surface Characteristics ◽  
Molecular Probes ◽  
Stimuli Responsive ◽  
Cancer Treatments ◽  
Effective Transport ◽  
Promising Solution ◽  
Delivery Vehicles ◽  
Cancer Theranostics

Conventional cancer treatments, such as surgical resection, radiotherapy, and chemotherapy, have achieved significant progress in cancer therapy. Nevertheless, some limitations (such as toxic side effects) are still existing for conventional therapies, which motivate efforts toward developing novel theranostic avenues. Owning many merits such as easy surface modification, unique optical properties, and high biocompatibility, gold nanoparticles (AuNPs and GNPs) have been engineered to serve as targeted delivery vehicles, molecular probes, sensors, and so on. Their small size and surface characteristics enable them to extravasate and access the tumor microenvironment (TME), which is a promising solution to realize highly effective treatments. Moreover, stimuli-responsive properties (respond to hypoxia and acidic pH) of nanoparticles to TME enable GNPs’ unrivaled control for effective transport of therapeutic cargos. In this review article, we primarily introduce the basic properties of GNPs, further discuss the recent progress in gold nanoparticles for cancer theranostics, with an additional concern about TME stimuli-responsive studies.

scholarly journals Well-defined single polymer nanoparticles for the antibody-targeted delivery of chemotherapeutic agents

2015 ◽  
Vol 6 (8) ◽  
pp. 1286-1299 ◽  
Author(s):  
D. D. Lane ◽  
D. Y. Chiu ◽  
F. Y. Su ◽  
S. Srinivasan ◽  
H. B. Kern ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Raft Polymerization ◽  
Chemotherapeutic Agents ◽  
Polymer Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Molecular Weights ◽  
Delivery Vehicles ◽  
Targeted Drug

Second generation polymeric brushes with molecular weights in excess of 106 Da were synthesize via RAFT polymerization for use as antibody targeted drug delivery vehicles.

Nanomaterials for Targeted Delivery of Anticancer Drugs: An Overview

2021 ◽  
Vol 06 ◽  
Author(s):  
Bhavna Choudhary ◽  
Pubalee Sarmah
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Chemotherapeutic Agents ◽  
Cancer Drug ◽  
Cancer Treatments ◽  
Area Of Interest ◽  
Efficient Delivery ◽  
Delivery Vehicles ◽  
Materials Used ◽  
Developing Area

: Application of nanomaterials in drug delivery is a rapidly developing area of interest. The main intention in the development of these drug delivery vehicles is to successfully know the targeted delivery-related efforts and carrying drugs to the required sites of therapeutic action with reduction in adverse side effects. The task for targeted drug delivery to reach pathological are-as has increased advances in nanomedicine. But the high toxicity of uncoated nanoparticles restricts the use in humans. So, to reduce toxicity, the encapsulation of nanoparticles is done with bio compatible materials. There are many efficient delivery systems thathave been developed in which nanoparticles are loaded with the cancer drug involvingbi-layer molecules. The fields of nanotechnology has always played a crucial role in electronics, biology and medicine. Its application can be ap-praised, as it involves the materials to be designed at atomic and molecular level.This article reviews different types of nano- materials used as delivery vehicles for chemotherapeutic agents and their mechanism of action that improve the therapeutic efficacy of the drugs. The recent scientific advances in the area of chemotherapy are also discussed with emphasizingthe fu-ture prospects in cancer treatments.

scholarly journals Cryo-shocked cancer cells for targeted drug delivery and vaccination

2020 ◽  
Vol 6 (50) ◽  
pp. eabc3013
Author(s):  
Tianyuan Ci ◽  
Hongjun Li ◽  
Guojun Chen ◽  
Zejun Wang ◽  
Jinqiang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Liquid Nitrogen ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Myeloid Leukemia ◽  
Live Cells ◽  
Simple Method ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Live cells have been vastly engineered into drug delivery vehicles to leverage their targeting capability and cargo release behavior. Here, we describe a simple method to obtain therapeutics-containing “dead cells” by shocking live cancer cells in liquid nitrogen to eliminate pathogenicity while preserving their major structure and chemotaxis toward the lesion site. In an acute myeloid leukemia (AML) mouse model, we demonstrated that the liquid nitrogen–treated AML cells (LNT cells) can augment targeted delivery of doxorubicin (DOX) toward the bone marrow. Moreover, LNT cells serve as a cancer vaccine and promote antitumor immune responses that prolong the survival of tumor-bearing mice. Preimmunization with LNT cells along with an adjuvant also protected healthy mice from AML cell challenge.

scholarly journals A supramolecular platform for controlling and optimizing molecular architectures of siRNA targeted delivery vehicles

2020 ◽  
Vol 6 (31) ◽  
pp. eabc2148
Author(s):  
Yuting Wen ◽  
Hongzhen Bai ◽  
Jingling Zhu ◽  
Xia Song ◽  
Guping Tang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Targeted Delivery ◽  
Tumor Therapy ◽  
Sirna Delivery ◽  
Targeted Gene Delivery ◽  
Delivery Vehicles ◽  
Molecular Architectures ◽  
Host Polymer

It requires multistep synthesis and conjugation processes to incorporate multifunctionalities into a polyplex gene vehicle to overcome numerous hurdles during gene delivery. Here, we describe a supramolecular platform to precisely control, screen, and optimize molecular architectures of siRNA targeted delivery vehicles, which is based on rationally designed host-guest complexation between a β-cyclodextrin–based cationic host polymer and a library of guest polymers with various PEG shape and size, and various density of ligands. The host polymer is responsible to load/unload siRNA, while the guest polymer is responsible to shield the vehicles from nonspecific cellular uptake, to prolong their circulation time, and to target tumor cells. A series of precisely controlled molecular architectures through a simple assembly process allow for a rapid optimization of siRNA delivery vehicles in vitro and in vivo for therapeutic siRNA-Bcl2 delivery and tumor therapy, indicating the platform is a powerful screening tool for targeted gene delivery vehicles.

Size dependent targeted delivery of gold nanoparticles modified with the IL-6R-specific aptamer AIR-3A to IL-6R-carrying cells

Nanoscale ◽  
2017 ◽  
Vol 9 (38) ◽  
pp. 14486-14498 ◽  
Author(s):  
Lisa Prisner ◽  
Nadine Bohn ◽  
Ulrich Hahn ◽  
Alf Mews
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Targeted Delivery ◽  
Receptor Ligand ◽  
Size Dependent ◽  
Au Clusters

The receptor–ligand mediated AuNP delivery to cells is strongly dependent on the particle size, as investigated by comparing very small “molecular” Au clusters of only 2 nm with larger 7 nm AuNPs and 36 nm AuNPs with a distinct surface plasmon resonance.

Immobilization of gold nanoparticles on folate-conjugated dendritic mesoporous silica-coated reduced graphene oxide nanosheets: a new nanoplatform for curcumin pH-controlled and targeted delivery

Soft Matter ◽  
2018 ◽  
Vol 14 (12) ◽  
pp. 2400-2410 ◽  
Author(s):  
Samira Malekmohammadi ◽  
Hassan Hadadzadeh ◽  
Hossein Farrokhpour ◽  
Zahra Amirghofran
Keyword(s):  
Gold Nanoparticles ◽  
Graphene Oxide ◽  
Folic Acid ◽  
Mesoporous Silica ◽  
Reduced Graphene Oxide ◽  
Targeted Delivery ◽  
Cell Imaging ◽  
Graphene Oxide Nanosheets ◽  
Reduced Graphene ◽  
Gold Nps

A nanocarrier for curcumin targeted delivery and cell imaging was prepared by immobilization of gold NPs on the folic acid-modified dendritic mesoporous silica-coated reduced graphene oxide nanosheets.

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