scholarly journals Well-defined single polymer nanoparticles for the antibody-targeted delivery of chemotherapeutic agents

2015 ◽  
Vol 6 (8) ◽  
pp. 1286-1299 ◽  
Author(s):  
D. D. Lane ◽  
D. Y. Chiu ◽  
F. Y. Su ◽  
S. Srinivasan ◽  
H. B. Kern ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Raft Polymerization ◽  
Chemotherapeutic Agents ◽  
Polymer Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Molecular Weights ◽  
Delivery Vehicles ◽  
Targeted Drug

Second generation polymeric brushes with molecular weights in excess of 106 Da were synthesize via RAFT polymerization for use as antibody targeted drug delivery vehicles.

scholarly journals Targeted Drug Delivery in Lipid-like Nanocages and Extracellular Vesicles

Acta Naturae ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 28-41 ◽  
Author(s):  
A. V. Sokolov ◽  
N. N. Kostin ◽  
L. A. Ovchinnikova ◽  
Y. A. Lomakin ◽  
A. A. Kudriaeva
Keyword(s):  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Structural Similarity ◽  
Biological Properties ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug ◽  
High Level

The possibility of targeted drug delivery to a specific tissue, organ, or cell has opened new promising avenues in treatment development. The technology of targeted delivery aims to create multifunctional carriers that are capable of long circulation in the patients organism and possess low toxicity at the same time. The surface of modern synthetic carriers has high structural similarity to the cell membrane, which, when combined with additional modifications, also promotes the transfer of biological properties in order to penetrate physiological barriers effectively. Along with artificial nanocages, further efforts have recently been devoted to research into extracellular vesicles that could serve as natural drug delivery vehicles. This review provides a detailed description of targeted delivery systems that employ lipid and lipid-like nanocages, as well as extracellular vesicles with a high level of biocompatibility, highlighting genetically encoded drug delivery vehicles.

scholarly journals Cryo-shocked cancer cells for targeted drug delivery and vaccination

2020 ◽  
Vol 6 (50) ◽  
pp. eabc3013
Author(s):  
Tianyuan Ci ◽  
Hongjun Li ◽  
Guojun Chen ◽  
Zejun Wang ◽  
Jinqiang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Liquid Nitrogen ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Myeloid Leukemia ◽  
Live Cells ◽  
Simple Method ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Live cells have been vastly engineered into drug delivery vehicles to leverage their targeting capability and cargo release behavior. Here, we describe a simple method to obtain therapeutics-containing “dead cells” by shocking live cancer cells in liquid nitrogen to eliminate pathogenicity while preserving their major structure and chemotaxis toward the lesion site. In an acute myeloid leukemia (AML) mouse model, we demonstrated that the liquid nitrogen–treated AML cells (LNT cells) can augment targeted delivery of doxorubicin (DOX) toward the bone marrow. Moreover, LNT cells serve as a cancer vaccine and promote antitumor immune responses that prolong the survival of tumor-bearing mice. Preimmunization with LNT cells along with an adjuvant also protected healthy mice from AML cell challenge.

scholarly journals Editorial: Stem Cells as Targeted Drug Delivery Vehicles

2020 ◽  
Vol 11 ◽  
Author(s):  
Gina D. Kusuma ◽  
Jessica E. Frith ◽  
Christopher G. Sobey ◽  
Rebecca Lim
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Targeted Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug

scholarly journals Design of Nanoparticle-Based Carriers for Targeted Drug Delivery

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Xiaojiao Yu ◽  
Ian Trase ◽  
Muqing Ren ◽  
Kayla Duval ◽  
Xing Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Active Targeting ◽  
Physical Interaction ◽  
Computational Simulations ◽  
Delivery Methods ◽  
Passive Targeting ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug

Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and cancer cells. In this paper, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting, and physical targeting) and compare methods of action, advantages, limitations, and the current stages of research. For the most commonly used nanoparticle carriers, fabrication methods are also reviewed. This is followed by a review of computational simulations and models on nanoparticle-based drug delivery.

Biomolecular-conjugated nanoparticles for biomedical applications

2016 ◽  
Vol 1 (01) ◽  
Author(s):  
Prachi Goyal ◽  
Kamani Parmar ◽  
Sonika Gupta ◽  
Mukesh Sharma ◽  
M. P. Dobhal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Targeted Drug Delivery ◽  
Molecular Motors ◽  
Biomedical Applications ◽  
Biological Functions ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug ◽  
Cellular Compartments

Bimolecular-conjugated nanoparticles (NP) demonstrate unique properties with wide-ranging applications in the diagnosis of infectious diseases as well as application in gene therapy and drug delivery therapies. The unique properties and utility of NP arise from a variety of attributes, including the similar size of nanoparticles and biomolecules. Biological functions depend primarily on units that have nanoscale dimensions, such as viruses, ribosomes, molecular motors and components of the extra cellular matrix. In addition, engineered devices at the nanoscale are small enough to interact directly with sub-cellular compartments and to probe intracellular events. This review focuses on the methods of nanoparticle interaction with different biomolecules such as antibodies, DNA, lipids, and proteins. More specifically, there is discussion about bioconjugation linkage and a summary of potential biomedical applications of bio-conjugated nanoparticles as targeted drug delivery vehicles.

scholarly journals BDNF-producing, amyloid β-specific CD4 T cells as targeted drug-delivery vehicles in Alzheimer's disease

EBioMedicine ◽  
2019 ◽  
Vol 43 ◽  
pp. 424-434 ◽  
Author(s):  
Ekaterina Eremenko ◽  
Kritika Mittal ◽  
Omer Berner ◽  
Nikita Kamenetsky ◽  
Anna Nemirovsky ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
T Cells ◽  
Targeted Drug Delivery ◽  
Cd4 T Cells ◽  
Amyloid Β ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug
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