Abstract TMP27: Tgfalpha Protects Oligodendrocytes Against Ischemic Injury and Promotes White Matter Integrity After Stroke

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Xuejiao Dai ◽  
Jingyan Zhao ◽  
Fei Xu ◽  
Wei Cai ◽  
Jun Chen ◽  
...  
Keyword(s):  
White Matter ◽  
Ischemic Injury ◽  
White Matter Integrity

scholarly journals Ultrasound Predicts White Matter Integrity after Hypothermia Therapy in Neonatal Hypoxic‐Ischemic Injury

2019 ◽  
Vol 29 (6) ◽  
pp. 743-749
Author(s):  
Jacqueline Salas ◽  
Nihaal Reddy ◽  
Kathryn A. Carson ◽  
Frances J. Northington ◽  
Thierry A.G.M. Huisman
Keyword(s):  
White Matter ◽  
Ischemic Injury ◽  
White Matter Integrity ◽  
Hypoxic Ischemic Injury

scholarly journals Regional White Matter Integrity Predicts Treatment Response to Escitalopram and Memantine in Geriatric Depression: A Pilot Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Beatrix Krause-Sorio ◽  
Prabha Siddarth ◽  
Michaela M. Milillo ◽  
Roza Vlasova ◽  
Linda Ercoli ◽  
...  
Keyword(s):  
White Matter ◽  
Pilot Study ◽  
Treatment Response ◽  
White Matter Integrity ◽  
Geriatric Depression

White matter integrity after cannabidiol administration for treatment resistant epilepsy

2021 ◽  
Vol 172 ◽  
pp. 106603
Author(s):  
J.T. Houston ◽  
R. Nenert ◽  
J.B. Allendorfer ◽  
E.M. Bebin ◽  
T.E. Gaston ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Integrity ◽  
Treatment Resistant

Arterial Stiffness Is Associated with White Matter Disruption and Cognitive Impairment: A Community-Based Cohort Study

2021 ◽  
Vol 80 (2) ◽  
pp. 567-576
Author(s):  
Fei Han ◽  
Fei-Fei Zhai ◽  
Ming-Li Li ◽  
Li-Xin Zhou ◽  
Jun Ni ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Arterial Stiffness ◽  
Cognitive Decline ◽  
Sex Education ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
White Matter Injury ◽  
White Matter Integrity ◽  
Cross Sectional

Background: Mechanisms through which arterial stiffness impacts cognitive function are crucial for devising better strategies to prevent cognitive decline. Objective: To examine the associations of arterial stiffness with white matter integrity and cognition in community dwellings, and to investigate whether white matter injury was the intermediate of the associations between arterial stiffness and cognition. Methods: This study was a cross-sectional analysis on 952 subjects (aged 55.5±9.1 years) who underwent diffusion tensor imaging and measurement of brachial-ankle pulse wave velocity (baPWV). Both linear regression and tract-based spatial statistics were used to investigate the association between baPWV and white matter integrity. The association between baPWV and global cognitive function, measured as the mini-mental state examination (MMSE) was evaluated. Mediation analysis was performed to assess the influence of white matter integrity on the association of baPWV with MMSE. Results: Increased baPWV was significantly associated with lower mean global fractional anisotropy (β= –0.118, p < 0.001), higher mean diffusivity (β= 0.161, p < 0.001), axial diffusivity (β= 0.160, p < 0.001), and radial diffusivity (β= 0.147, p < 0.001) after adjustment of age, sex, and hypertension, which were measures having a direct effect on arterial stiffness and white matter integrity. After adjustment of age, sex, education, apolipoprotein E ɛ4, cardiovascular risk factors, and brain atrophy, we found an association of increased baPWV with worse performance on MMSE (β= –0.093, p = 0.011). White matter disruption partially mediated the effect of baPWV on MMSE. Conclusion: Arterial stiffness is associated with white matter disruption and cognitive decline. Reduced white matter integrity partially explained the effect of arterial stiffness on cognition.

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