scholarly journals Ultrasound Predicts White Matter Integrity after Hypothermia Therapy in Neonatal Hypoxic‐Ischemic Injury

2019 ◽  
Vol 29 (6) ◽  
pp. 743-749
Author(s):  
Jacqueline Salas ◽  
Nihaal Reddy ◽  
Kathryn A. Carson ◽  
Frances J. Northington ◽  
Thierry A.G.M. Huisman
Keyword(s):  
White Matter ◽  
Ischemic Injury ◽  
White Matter Integrity ◽  
Hypoxic Ischemic Injury

scholarly journals Differential Progression of Magnetization Transfer Imaging Changes Depending on Severity of Cerebral Hypoxic-Ischemic Injury

2008 ◽  
Vol 28 (9) ◽  
pp. 1613-1623 ◽  
Author(s):  
Ursula I Tuor ◽  
Shuzhen Meng ◽  
Min Qiao ◽  
Nicole B Webster ◽  
Shauna M Crowley ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetization Transfer ◽  
Ischemic Injury ◽  
Subcortical White Matter ◽  
Cerebral Injury ◽  
Magnetization Transfer Ratio ◽  
Magnetization Transfer Imaging ◽  
Cerebral Hypoxia ◽  
Hypoxia Ischemia ◽  
Hypoxic Ischemic Injury

We hypothesized that magnetic resonance magnetization transfer (MT) imaging would be sensitive for detecting cerebral ischemic injury in white matter of neonatal brain. We compared the progression of changes in T2 and the MT ratio (MTR) after cerebral hypoxic-ischemic insults of differing severity in neonatal rats. Magnetization transfer imaging parameters were first optimized, and then MTR and T2 maps were acquired at various times after a mild (rather selective white matter) or substantial insult produced by unilateral cerebral hypoxia—ischemia. Depending on insult severity, time after insult, and region (e.g., subcortical white matter or cortex), cerebral hypoxia—ischemia produced reductions in MTR and an increase in T2. The exception was acutely at 1 to 5 h at which time points MTR was reduced ipsilaterally in white matter, whereas T2 was not affected significantly. Progression of imaging changes differed in rats grouped according to whether gross damage was present after chronic recovery. Behavioral changes were generally associated with chronic reductions in MTR and gross brain damage. Magnetization transfer imaging was capable of early detection of hypoxic-ischemic injury and particularly sensitive for identifying the progression of cerebral injury in white matter. Magnetization transfer ratio has potential for assisting with early diagnosis and treatment assessment for infants affected by perinatal hypoxia—ischemia.

Abstract TMP27: Tgfalpha Protects Oligodendrocytes Against Ischemic Injury and Promotes White Matter Integrity After Stroke

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Xuejiao Dai ◽  
Jingyan Zhao ◽  
Fei Xu ◽  
Wei Cai ◽  
Jun Chen ◽  
...  
Keyword(s):  
White Matter ◽  
Ischemic Injury ◽  
White Matter Integrity
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