scholarly journals Subtractive Cloning Identifies Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1) Increased Gene Expression Following Focal Stroke

Stroke ◽  
1998 ◽  
Vol 29 (2) ◽  
pp. 516-520 ◽  
Author(s):  
Xinkang Wang ◽  
Frank C. Barone ◽  
Raymond F. White ◽  
Giora Z. Feuerstein
Keyword(s):  
Gene Expression ◽  
Matrix Metalloproteinase ◽  
Tissue Inhibitor ◽  
Matrix Metalloproteinase 1 ◽  
Subtractive Cloning

scholarly journals Stimulation of matrix-metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression in rats by the preovulatory prolactin peak

1999 ◽  
pp. 583-589 ◽  
Author(s):  
B Hirsch ◽  
I Knoke ◽  
S Leonhardt ◽  
L Pitzel ◽  
H Jarry ◽  
...  
Keyword(s):  
Gene Expression ◽  
Matrix Metalloproteinase ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Collagenase Activity ◽  
Tissue Inhibitor ◽  
Prolactin Release ◽  
Lh Surge ◽  
Matrix Metalloproteinase 1 ◽  
Additional Group ◽  
Stimulation Of

Since structural luteolysis involves deterioration of tissue, the gene expression of matrix-metalloproteinase-1 (MMP-1) and the respective tissue inhibitor of this metalloprotease (TIMP-1) were measured at various times on the day of pro-oestrus and in animals in which the preovulatory prolactin surge was blocked for the duration of 3 cycles by bromocriptine. An additional group of prolactin-blocked rats received a prolactin replacement injection on the afternoon of pro-oestrus. In spontaneously pro-oestrous rats, MMP-1 and TIMP-1 gene expression increased significantly (P<0.01) prior to the occurrence of the preovulatory LH surge but simultaneously with the onset of the preovulatory prolactin surge. When prolactin release was blocked by bromocriptine for 3 cycles, no such changes were observed during the afternoon of pro-oestrus. However, an intraperitoneal injection of bovine prolactin at the time when the preovulatory prolactin surge occurs normally, increased MMP-1 and TIMP-1 gene expression (P<0.01). These results indicate that MMP-1 and TIMP-1 gene expression are stimulated by the preovulatory prolactin surge. Previous work has shown that the preovulatory LH surge activates the enzymatic cascade which leads to increased collagenase activity.

scholarly journals Tissue Inhibitor of Matrix Metalloproteinase-1 in Norepinephrine-Induced Remodeling of the Mouse Heart

2007 ◽  
Vol 20 (6) ◽  
pp. 825-836 ◽  
Author(s):  
Henning Meier ◽  
Jörg Bullinger ◽  
Alexander Deten ◽  
Grit Marx ◽  
Steffen Rabald ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Mouse Heart ◽  
Tissue Inhibitor ◽  
Matrix Metalloproteinase 1
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