Comparison of gene expression of tissue inhibitor of matrix metalloproteinase-1 between continuous and intermittent distraction osteogenesis: A quantitative study on rabbits

2012 ◽  
Vol 40 (7) ◽  
pp. e185-e188 ◽  
Author(s):  
Xi Ling Liu ◽  
Lim Kwong Cheung ◽  
Hua Xiang Zhang ◽  
Jun Yuan Li ◽  
Li Ma ◽  
...  
Keyword(s):  
Gene Expression ◽  
Matrix Metalloproteinase ◽  
Quantitative Study ◽  
Distraction Osteogenesis ◽  
Tissue Inhibitor ◽  
Matrix Metalloproteinase 1

scholarly journals Stimulation of matrix-metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression in rats by the preovulatory prolactin peak

1999 ◽  
pp. 583-589 ◽  
Author(s):  
B Hirsch ◽  
I Knoke ◽  
S Leonhardt ◽  
L Pitzel ◽  
H Jarry ◽  
...  
Keyword(s):  
Gene Expression ◽  
Matrix Metalloproteinase ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Collagenase Activity ◽  
Tissue Inhibitor ◽  
Prolactin Release ◽  
Lh Surge ◽  
Matrix Metalloproteinase 1 ◽  
Additional Group ◽  
Stimulation Of

Since structural luteolysis involves deterioration of tissue, the gene expression of matrix-metalloproteinase-1 (MMP-1) and the respective tissue inhibitor of this metalloprotease (TIMP-1) were measured at various times on the day of pro-oestrus and in animals in which the preovulatory prolactin surge was blocked for the duration of 3 cycles by bromocriptine. An additional group of prolactin-blocked rats received a prolactin replacement injection on the afternoon of pro-oestrus. In spontaneously pro-oestrous rats, MMP-1 and TIMP-1 gene expression increased significantly (P<0.01) prior to the occurrence of the preovulatory LH surge but simultaneously with the onset of the preovulatory prolactin surge. When prolactin release was blocked by bromocriptine for 3 cycles, no such changes were observed during the afternoon of pro-oestrus. However, an intraperitoneal injection of bovine prolactin at the time when the preovulatory prolactin surge occurs normally, increased MMP-1 and TIMP-1 gene expression (P<0.01). These results indicate that MMP-1 and TIMP-1 gene expression are stimulated by the preovulatory prolactin surge. Previous work has shown that the preovulatory LH surge activates the enzymatic cascade which leads to increased collagenase activity.

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