Horizontal Guided Bone Regeneration in the Posterior Maxilla Using Recombinant Human Platelet-Derived Growth Factor: A Case Report

2013 ◽  
Vol 33 (4) ◽  
pp. 421-425 ◽  
Author(s):  
Istvan A Urban ◽  
Jaime L Lozada ◽  
Sascha A Jovanovic ◽  
Katalin Nagy
Keyword(s):  
Case Report ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Human Platelet ◽  
Guided Bone Regeneration ◽  
Platelet Derived Growth Factor ◽  
Posterior Maxilla

Simultaneous Vertical Guided Bone Regeneration and Guided Tissue Regeneration in the Posterior Maxilla Using Recombinant Human Platelet-Derived Growth Factor: A Case Report

2009 ◽  
Vol 35 (5) ◽  
pp. 251-256 ◽  
Author(s):  
Istvan Urban ◽  
Nicholas Caplanis ◽  
Jaime L. Lozada
Keyword(s):  
Case Report ◽  
Growth Factor ◽  
Alveolar Bone ◽  
Human Platelet ◽  
Periodontal Regeneration ◽  
Platelet Derived Growth Factor ◽  
Autogenous Bone ◽  
Sinus Augmentation ◽  
Ridge Augmentation ◽  
Posterior Maxilla

Abstract This clinical case report describes and demonstrates successful use of recombinant human platelet-derived growth factor (rhPDGF-BB) in conjunction with autogenous bone, anorganic bone mineral, and barrier membranes to reconstruct severe alveolar bone defects. A combined sinus augmentation and vertical alveolar ridge augmentation was successfully performed. In addition, a significant amount of periodontal bone gain was achieved in close apposition to a previously denuded root surface, which is significant from a periodontal standpoint, given the possibility of vertical periodontal regeneration.

scholarly journals Recombinant human PDGF-BB in combination with mineralized freeze-dried bone allograft in the treatment of Grade II furcation involvement: A case report

2021 ◽  
Vol 11 ◽  
pp. 4
Author(s):  
Abdullah Saleh Almutairi
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Growth Factor ◽  
Human Platelet ◽  
Bone Allograft ◽  
Platelet Derived Growth Factor ◽  
Allograft Bone ◽  
Freeze Dried ◽  
Furcation Involvement ◽  
Grade Ii

Recombinant human platelet-derived growth factor-BB (rhPDGF-BB) is commercially available biomaterial that can be used to regenerate the lost periodontal structure due to progression of periodontitis. The present case describes the surgical treatment of localized periodontitis with furcation Grade II involvement using platelet-derived growth factor BB (growth-factor enhanced matrix 21S) in combination with particulate allograft bone (mineralize freeze-dried bone allograft [FDBA]).This case report showed complete furcation closure after using rhPDGF-BB in combination with FDBA to treat localized periodontitis case with Grade II furcation involvement.

scholarly journals Recombinant Human Platelet–Derived Growth Factor: A Systematic Review of Clinical Findings in Oral Regenerative Procedures

2020 ◽  
pp. 238008442092135 ◽  
Author(s):  
L. Tavelli ◽  
A. Ravidà ◽  
S. Barootchi ◽  
L. Chambrone ◽  
W.V. Giannobile
Keyword(s):  
Systematic Review ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Clinical Benefit ◽  
Human Platelet ◽  
Gingival Recession ◽  
Platelet Derived Growth Factor ◽  
Ridge Preservation ◽  
Alveolar Ridge ◽  
Alveolar Ridge Preservation

Aim: The use of recombinant human platelet-derived growth factor–BB (rhPDGF) has received Food and Drug Administration approval for the treatment of periodontal and orthopedic bone defects and dermal wound healing. Many studies have investigated its regenerative potential in a variety of other oral clinical indications. The aim of this systematic review was to assess the efficacy, safety, and clinical benefit of recombinant human platelet-derived growth factor (rhPDGF) use for alveolar bone and/or soft tissue regeneration. Material and Methods: Comprehensive electronic and manual literature searches according to the PRISMA guidelines were performed to identify interventional and observational studies evaluating the regenerative applications of rhPDGF-BB. The primary outcomes were the safety, efficacy, and overall clinical benefit of rhPDGF use in oral regenerative procedures. Results: Sixty-three human clinical studies (mean ± SD follow-up period of 10.7 ± 3.3 mo) were included in the qualitative analysis. No serious adverse effects were reported in any of the 63 studies, aside from the postoperative complications routinely associated with surgical therapy. Use of rhPDGF was shown to be beneficial when combined with allografts, xenografts, and alloplasts (the latter tricalcium phosphate [β-TCP]) for the treatment of periodontal defects and gingival recession. The use of rhPDGF also led to favorable clinical outcomes when combined with allografts or xenografts for guided bone regeneration (GBR) and alveolar ridge preservation. While favorable clinical results support the use of the combination of rhPDGF plus allograft or xenograft for GBR, ARP, and sinus floor augmentation, current data support the use of rhPDGF and alloplasts (e.g., β-TCP) only in periodontal defects and gingival recession. Conclusions: Based on the clinical evidence, rhPDGF is safe and provides clinical benefits when used in combination with bone allografts, xenograft, or β-TCP for the treatment of intrabony and furcation periodontal defects and gingival recession or when used with allografts or xenograft for GBR and ARP (PROSPERO CRD42020142446). Knowledge Transfer Statement: Clinicians should be aware that rhPDGF is a safe and effective approach for the treatment of intrabony and furcation periodontal defects and gingival recession or when used with allografts or xenograft for bone regeneration and alveolar ridge preservation. With consideration of cost and patient preference, this result could lead to more appropriate therapeutic decisions.

Treatment of stingray injury with topical becaplermin gel

1999 ◽  
Vol 89 (10) ◽  
pp. 531-533 ◽  
Author(s):  
PJ Baldinger
Keyword(s):  
Case Report ◽  
Growth Factor ◽  
Topical Application ◽  
Human Platelet ◽  
Wound Care ◽  
Platelet Derived Growth Factor ◽  
Tissue Necrosis ◽  
Life Threatening

Stingray injuries are most commonly characterized by localized pain, ulceration, and edema; however, potentially serious sequelae may result, including tissue necrosis and life-threatening infection. This case report describes a stingray injury that had progressed to ulceration and was treated with topical application of recombinant human platelet-derived growth factor-BB (becaplermin gel 0.01%) and a standardized regimen of wound care.

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