Bone Regeneration of Tibial Defects in Rats with Enzymatic Hydrogelation of Gelatin Derivative and Recombinant Human Platelet-Derived Growth Factor-BB Complex

2013 ◽  
Vol 28 (5) ◽  
pp. 1377-1385
Author(s):  
Daisuke Kondo ◽  
Yoichiro Ogino ◽  
Yasunori Ayukawa ◽  
Shinji Sakai ◽  
Koei Kawakami ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Regeneration ◽  
Human Platelet ◽  
Platelet Derived Growth Factor ◽  
Gelatin Derivative

scholarly journals Recombinant Human Platelet–Derived Growth Factor: A Systematic Review of Clinical Findings in Oral Regenerative Procedures

2020 ◽  
pp. 238008442092135 ◽  
Author(s):  
L. Tavelli ◽  
A. Ravidà ◽  
S. Barootchi ◽  
L. Chambrone ◽  
W.V. Giannobile
Keyword(s):  
Systematic Review ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Clinical Benefit ◽  
Human Platelet ◽  
Gingival Recession ◽  
Platelet Derived Growth Factor ◽  
Ridge Preservation ◽  
Alveolar Ridge ◽  
Alveolar Ridge Preservation

Aim: The use of recombinant human platelet-derived growth factor–BB (rhPDGF) has received Food and Drug Administration approval for the treatment of periodontal and orthopedic bone defects and dermal wound healing. Many studies have investigated its regenerative potential in a variety of other oral clinical indications. The aim of this systematic review was to assess the efficacy, safety, and clinical benefit of recombinant human platelet-derived growth factor (rhPDGF) use for alveolar bone and/or soft tissue regeneration. Material and Methods: Comprehensive electronic and manual literature searches according to the PRISMA guidelines were performed to identify interventional and observational studies evaluating the regenerative applications of rhPDGF-BB. The primary outcomes were the safety, efficacy, and overall clinical benefit of rhPDGF use in oral regenerative procedures. Results: Sixty-three human clinical studies (mean ± SD follow-up period of 10.7 ± 3.3 mo) were included in the qualitative analysis. No serious adverse effects were reported in any of the 63 studies, aside from the postoperative complications routinely associated with surgical therapy. Use of rhPDGF was shown to be beneficial when combined with allografts, xenografts, and alloplasts (the latter tricalcium phosphate [β-TCP]) for the treatment of periodontal defects and gingival recession. The use of rhPDGF also led to favorable clinical outcomes when combined with allografts or xenografts for guided bone regeneration (GBR) and alveolar ridge preservation. While favorable clinical results support the use of the combination of rhPDGF plus allograft or xenograft for GBR, ARP, and sinus floor augmentation, current data support the use of rhPDGF and alloplasts (e.g., β-TCP) only in periodontal defects and gingival recession. Conclusions: Based on the clinical evidence, rhPDGF is safe and provides clinical benefits when used in combination with bone allografts, xenograft, or β-TCP for the treatment of intrabony and furcation periodontal defects and gingival recession or when used with allografts or xenograft for GBR and ARP (PROSPERO CRD42020142446). Knowledge Transfer Statement: Clinicians should be aware that rhPDGF is a safe and effective approach for the treatment of intrabony and furcation periodontal defects and gingival recession or when used with allografts or xenograft for bone regeneration and alveolar ridge preservation. With consideration of cost and patient preference, this result could lead to more appropriate therapeutic decisions.

scholarly journals Human platelet-derived growth factor. Purification and resolution into two active protein fractions.

1981 ◽  
Vol 256 (17) ◽  
pp. 8896-8899 ◽  
Author(s):  
T F Deuel ◽  
J S Huang ◽  
R T Proffitt ◽  
J U Baenziger ◽  
D Chang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Human Platelet ◽  
Protein Fractions ◽  
Platelet Derived Growth Factor ◽  
Active Protein

A Review of Platelet Derived Growth Factor Playing Pivotal Role in Bone Regeneration

2014 ◽  
Vol 40 (3) ◽  
pp. 330-340 ◽  
Author(s):  
Prasun Shah ◽  
Louise Keppler ◽  
James Rutkowski
Keyword(s):  
Growth Factor ◽  
Bone Regeneration ◽  
Bone Grafting ◽  
Bone Growth ◽  
Platelet Derived Growth Factor ◽  
Future Application ◽  
Second Phase ◽  
Bony Defect ◽  
Wound Site ◽  
Functioning Capillaries

This article is focused on the literature review and study of recent advances in the field of bone grafting, which involves platelet-derived growth factor (PDGF) as one of the facilitating factors in bone regeneration. This article includes a description of the mechanism of PDGF for use in surgeries where bone grafting is required, which promotes future application of PDGF for faster bone regeneration or inhibition of bone growth if required as in osteosarcoma. The important specific activities of PDGF include mitogenesis (increase in the cell populations of healing cells), angiogenesis (endothelial mitoses into functioning capillaries), and macrophage activation (debridement of the wound site and a second phase source of growth factors for continued repair and bone regeneration). Thus PDGF can be utilized in wound with bone defect to conceal the wound with repair of bony defect.

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