Antimicrobial Peptide Coating of Dental Implants: Biocompatibility Assessment of Recombinant Human Beta Defensin-2 for Human Cells

2013 ◽  
Vol 28 (4) ◽  
pp. 982-988 ◽  
Author(s):  
Patrick H. Warnke ◽  
Eske Voss ◽  
Paul A. J. Russo ◽  
Sebastien Stephens ◽  
Michael Kleine ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Dental Implants ◽  
Human Cells ◽  
Peptide Coating

High-density antimicrobial peptide coating with broad activity and low cytotoxicity against human cells

2016 ◽  
Vol 33 ◽  
pp. 64-77 ◽  
Author(s):  
Akhilesh Rai ◽  
Sandra Pinto ◽  
Marta B. Evangelista ◽  
Helena Gil ◽  
Silvar Kallip ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Human Cells ◽  
High Density ◽  
Low Cytotoxicity ◽  
Peptide Coating

In vivo osseointegration of dental implants with an antimicrobial peptide coating

2017 ◽  
Vol 28 (5) ◽  
Author(s):  
X. Chen ◽  
X. C. Zhou ◽  
S. Liu ◽  
R. F. Wu ◽  
C. Aparicio ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Dental Implants ◽  
Peptide Coating

scholarly journals Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 421
Author(s):  
Areetha R. D’Souza ◽  
Matthew R. Necelis ◽  
Alona Kulesha ◽  
Gregory A. Caputo ◽  
Olga V. Makhlynets
Keyword(s):  
Amino Acid ◽  
Antimicrobial Peptides ◽  
Antimicrobial Peptide ◽  
Mechanism Of Action ◽  
Bactericidal Activity ◽  
Antimicrobial Agents ◽  
Human Cells ◽  
Side Chains ◽  
Natural Amino Acid ◽  
Proteolytic Stability

Antimicrobial peptides (AMPs) present a promising scaffold for the development of potent antimicrobial agents. Substitution of tryptophan by non-natural amino acid Azulenyl-Alanine (AzAla) would allow studying the mechanism of action of AMPs by using unique properties of this amino acid, such as ability to be excited separately from tryptophan in a multi-Trp AMPs and environmental insensitivity. In this work, we investigate the effect of Trp→AzAla substitution in antimicrobial peptide buCATHL4B (contains three Trp side chains). We found that antimicrobial and bactericidal activity of the original peptide was preserved, while cytocompatibility with human cells and proteolytic stability was improved. We envision that AzAla will find applications as a tool for studies of the mechanism of action of AMPs. In addition, incorporation of this non-natural amino acid into AMP sequences could enhance their application properties.

Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model

Biomaterials ◽  
2017 ◽  
Vol 116 ◽  
pp. 69-81 ◽  
Author(s):  
Kai Yu ◽  
Joey C.Y. Lo ◽  
Mei Yan ◽  
Xiaoqiang Yang ◽  
Donald E. Brooks ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Urinary Infection ◽  
Infection Model ◽  
Peptide Coating

Antimicrobial-peptide coating that ruptures the wall of Gram positive bacteria

2014 ◽  
Vol 30 ◽  
pp. e86-e87
Author(s):  
X. Chen ◽  
H. Hirt ◽  
Y. Li ◽  
S.-U. Gorr ◽  
C. Aparicio
Keyword(s):  
Antimicrobial Peptide ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Peptide Coating

scholarly journals A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells

FEBS Journal ◽  
2016 ◽  
Vol 283 (11) ◽  
pp. 2115-2131 ◽  
Author(s):  
Katia Pane ◽  
Valeria Sgambati ◽  
Anna Zanfardino ◽  
Giovanni Smaldone ◽  
Valeria Cafaro ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antimicrobial Peptide ◽  
Apolipoprotein E ◽  
Human Cells ◽  
Immunomodulatory Effects ◽  
Cationic Antimicrobial Peptide ◽  
Human Apolipoprotein

A peptide coating preventing the attachment of Porphyromonas gingivalis on the surfaces of dental implants

2020 ◽  
Vol 55 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Dongdong Fang ◽  
Sivan Yuran ◽  
Meital Reches ◽  
Raisa Catunda ◽  
Liran Levin ◽  
...  
Keyword(s):  
Dental Implants ◽  
Porphyromonas Gingivalis ◽  
Peptide Coating

Cost-effectiveness of dental implants: a utility analysis

1990 ◽  
Vol 54 (11) ◽  
pp. 688-689 ◽  
Author(s):  
J Jacobson ◽  
B Maxson ◽  
K Mays ◽  
J Peebles ◽  
C Kowalski
Keyword(s):  
Cost Effectiveness ◽  
Dental Implants ◽  
Utility Analysis

Alpha-Tocopherol Protects Cultured Human Cells from the Acute Lethal Cytotoxicity of Dioxin

2002 ◽  
Vol 72 (3) ◽  
pp. 147-153 ◽  
Author(s):  
Kei-Ichi Hirai ◽  
Jie-Hong Pan ◽  
Ying-Bo Shui ◽  
Eriko Simamura ◽  
Hiroki Shimada ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Damage ◽  
Smooth Endoplasmic Reticulum ◽  
Dehydroascorbic Acid ◽  
Human Cells ◽  
Alpha Tocopherol ◽  
Cervical Cancer Cells ◽  
Cultured Human Cells ◽  
Nuclear Damage ◽  
Conjunctival Epithelial Cells

The possible protection of cultured human cells from acute dioxin injury by antioxidants was investigated. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), caused vacuolization of the smooth endoplasmic reticulum and Golgi apparatus in cultured human conjunctival epithelial cells and cervical cancer cells. Subsequent nuclear damage included a deep irregular indentation resulting in cell death. A dosage of 30–40 ng/mL TCDD induced maximal intracellular production of H2O2 at 30 minutes and led to severe cell death (0–31% survival) at two hours. A dose of 1.7 mM alpha-tocopherol or 1 mM L-dehydroascorbic acid significantly protected human cells against acute TCDD injuries (78–97% survivals), but vitamin C did not provide this protection. These results indicate that accidental exposure to fatal doses of TCDD causes cytoplasmic free radical production within the smooth endoplasmic reticular systems, resulting in severe cytotoxicity, and that vitamin E and dehydroascorbic acid can protect against TCDD-induced cell damage.

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