scholarly journals A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells

FEBS Journal ◽  
2016 ◽  
Vol 283 (11) ◽  
pp. 2115-2131 ◽  
Author(s):  
Katia Pane ◽  
Valeria Sgambati ◽  
Anna Zanfardino ◽  
Giovanni Smaldone ◽  
Valeria Cafaro ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antimicrobial Peptide ◽  
Apolipoprotein E ◽  
Human Cells ◽  
Immunomodulatory Effects ◽  
Cationic Antimicrobial Peptide ◽  
Human Apolipoprotein

scholarly journals Preparation and in Vitro Evaluation of New Composite Mesh Functionalized with Cationic Antimicrobial Peptide

Materials ◽  
2019 ◽  
Vol 12 (10) ◽  
pp. 1676 ◽  
Author(s):  
Pengbi Liu ◽  
Nanliang Chen ◽  
Jinhua Jiang ◽  
Xuejun Wen
Keyword(s):  
Mechanical Properties ◽  
Antibacterial Activity ◽  
Antimicrobial Peptide ◽  
In Vitro Release ◽  
In Vitro Cytotoxicity ◽  
Dermal Fibroblasts ◽  
Composite Mesh ◽  
Cationic Antimicrobial Peptide ◽  
Surgical Meshes

Infection caused by bacteria in hernia repair site is a severe complication, and patients have to undergo a second surgery to remove the infected prosthesis. In this study, we developed a composite biological safe mesh with antibacterial activity. The composite mesh is composed of large pore polypropylene (PP) mesh, poly-caprolactone (PCL) and antimicrobial peptide (PEP-1), which we synthesized in our lab. Fourier transformed infrared (FTIR) spectroscopy was utilized to analyze the functional groups. The surface morphology, in vitro release characters, mechanical properties, antibacterial activities, and in vitro cytotoxicity of modified mesh were evaluated. Results showed that PEP-1 was loaded in fibers successfully and could diffuse from nanofibers to inhibit bacteria (E. coli) growth. However, the modified mesh did not show inhibition to S. aureus. The mechanical properties of fabricated mesh showed no difference with two commercial surgical meshes. What is more, modified mesh was proved to be nontoxic to human dermal fibroblasts, indicating that this method to fabricate meshes with antibacterial activity is feasible and provides a new strategy for the development of surgical meshes.

Highly efficient nanomedicine from cationic antimicrobial peptide-protected Ag nanoclusters

2021 ◽  
Author(s):  
Zhikai Ye ◽  
Haishuang Zhu ◽  
Shan Zhang ◽  
Jing Li ◽  
Jin Wang ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Biological Systems ◽  
Cationic Antimicrobial Peptide ◽  
Highly Efficient ◽  
Antimicrobial Efficiency ◽  
Ag Nanoclusters ◽  
Fine Tune

Designing the homogeneous assembly of the bio–nano interface to fine-tune the interactions between the nanoprobes and biological systems is of prime importance to improve the antimicrobial efficiency of nanomedicines.

scholarly journals Characterization of a human apolipoprotein E gene enhancer element and its associated protein factors.

1990 ◽  
Vol 265 (16) ◽  
pp. 9496-9504 ◽  
Author(s):  
D J Chang ◽  
Y K Paik ◽  
T P Leren ◽  
D W Walker ◽  
G J Howlett ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Enhancer Element ◽  
E Gene ◽  
Human Apolipoprotein ◽  
Apolipoprotein E Gene ◽  
Gene Enhancer

scholarly journals Genetic variation in human apolipoprotein E

1982 ◽  
Vol 23 (8) ◽  
pp. 1174-1182 ◽  
Author(s):  
M R Wardell ◽  
P A Suckling ◽  
E D Janus
Keyword(s):  
Genetic Variation ◽  
Apolipoprotein E ◽  
Human Apolipoprotein

Accumulation of Human Apolipoprotein-E in Rat Plasma After in vivo Intramuscular Injection of Naked DNA

1994 ◽  
Vol 200 (1) ◽  
pp. 298-305 ◽  
Author(s):  
V.M. Fazio ◽  
S. Fazio ◽  
M. Rinaldi ◽  
M.V. Catani ◽  
S. Zotti ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Intramuscular Injection ◽  
Rat Plasma ◽  
Human Apolipoprotein ◽  
Naked Dna

scholarly journals Behavior of human apolipoprotein E in aqueous solutions and at interfaces.

1985 ◽  
Vol 260 (30) ◽  
pp. 16375-16382 ◽  
Author(s):  
S Yokoyama ◽  
Y Kawai ◽  
S Tajima ◽  
A Yamamoto
Keyword(s):  
Aqueous Solutions ◽  
Apolipoprotein E ◽  
Human Apolipoprotein

scholarly journals Association of human apolipoprotein E with lipoproteins secreted by transfected McA RH7777 cells

1998 ◽  
Vol 39 (7) ◽  
pp. 1372-1381 ◽  
Author(s):  
Catherine A. Reardon ◽  
Lydia Blachowicz ◽  
Krista M. Watson ◽  
Eliav Barr ◽  
Godfrey S. Getz
Keyword(s):  
Apolipoprotein E ◽  
Human Apolipoprotein
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