High-density antimicrobial peptide coating with broad activity and low cytotoxicity against human cells

2016 ◽  
Vol 33 ◽  
pp. 64-77 ◽  
Author(s):  
Akhilesh Rai ◽  
Sandra Pinto ◽  
Marta B. Evangelista ◽  
Helena Gil ◽  
Silvar Kallip ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Human Cells ◽  
High Density ◽  
Low Cytotoxicity ◽  
Peptide Coating

Antimicrobial Peptide Coating of Dental Implants: Biocompatibility Assessment of Recombinant Human Beta Defensin-2 for Human Cells

2013 ◽  
Vol 28 (4) ◽  
pp. 982-988 ◽  
Author(s):  
Patrick H. Warnke ◽  
Eske Voss ◽  
Paul A. J. Russo ◽  
Sebastien Stephens ◽  
Michael Kleine ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Dental Implants ◽  
Human Cells ◽  
Peptide Coating

scholarly journals Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 421
Author(s):  
Areetha R. D’Souza ◽  
Matthew R. Necelis ◽  
Alona Kulesha ◽  
Gregory A. Caputo ◽  
Olga V. Makhlynets
Keyword(s):  
Amino Acid ◽  
Antimicrobial Peptides ◽  
Antimicrobial Peptide ◽  
Mechanism Of Action ◽  
Bactericidal Activity ◽  
Antimicrobial Agents ◽  
Human Cells ◽  
Side Chains ◽  
Natural Amino Acid ◽  
Proteolytic Stability

Antimicrobial peptides (AMPs) present a promising scaffold for the development of potent antimicrobial agents. Substitution of tryptophan by non-natural amino acid Azulenyl-Alanine (AzAla) would allow studying the mechanism of action of AMPs by using unique properties of this amino acid, such as ability to be excited separately from tryptophan in a multi-Trp AMPs and environmental insensitivity. In this work, we investigate the effect of Trp→AzAla substitution in antimicrobial peptide buCATHL4B (contains three Trp side chains). We found that antimicrobial and bactericidal activity of the original peptide was preserved, while cytocompatibility with human cells and proteolytic stability was improved. We envision that AzAla will find applications as a tool for studies of the mechanism of action of AMPs. In addition, incorporation of this non-natural amino acid into AMP sequences could enhance their application properties.

Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model

Biomaterials ◽  
2017 ◽  
Vol 116 ◽  
pp. 69-81 ◽  
Author(s):  
Kai Yu ◽  
Joey C.Y. Lo ◽  
Mei Yan ◽  
Xiaoqiang Yang ◽  
Donald E. Brooks ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Urinary Infection ◽  
Infection Model ◽  
Peptide Coating

scholarly journals Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity against Human Cells of a Peptide Derived from Bovine αS1-Casein

Molecules ◽  
2018 ◽  
Vol 23 (5) ◽  
pp. 1220 ◽  
Author(s):  
Juncai Hou ◽  
Zhijing Liu ◽  
Songsong Cao ◽  
Haimei Wang ◽  
Chenggang Jiang ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Broad Spectrum ◽  
Human Cells ◽  
Low Cytotoxicity

Strategies from nature: polycaprolactone-based mimetic antimicrobial peptide block copolymers with low cytotoxicity and excellent antibacterial efficiency

2019 ◽  
Vol 10 (8) ◽  
pp. 945-953 ◽  
Author(s):  
Xinyu Zhou ◽  
Jing He ◽  
Chuncai Zhou
Keyword(s):  
Drug Resistance ◽  
Block Copolymers ◽  
Antimicrobial Peptide ◽  
Diblock Copolymers ◽  
Antibacterial Activities ◽  
Antibacterial Efficiency ◽  
Bactericidal Mechanism ◽  
Low Cytotoxicity

PCL16-b-Kn diblock copolymers exhibit excellent antibacterial activities and low cytotoxicity. Meanwhile, they act by the pore-forming bactericidal mechanism without inducement of drug resistance.

scholarly journals Interrogation of allelic chromatin states in human cells by high-density ChIP-genotyping

Epigenetics ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. 1238-1251 ◽  
Author(s):  
Nicholas Light ◽  
Véronique Adoue ◽  
Bing Ge ◽  
Shu-Huang Chen ◽  
Tony Kwan ◽  
...  
Keyword(s):  
Human Cells ◽  
High Density ◽  
Chromatin States

Antimicrobial-peptide coating that ruptures the wall of Gram positive bacteria

2014 ◽  
Vol 30 ◽  
pp. e86-e87
Author(s):  
X. Chen ◽  
H. Hirt ◽  
Y. Li ◽  
S.-U. Gorr ◽  
C. Aparicio
Keyword(s):  
Antimicrobial Peptide ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Peptide Coating

scholarly journals TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

2014 ◽  
Vol 42 (10) ◽  
pp. 6762-6773 ◽  
Author(s):  
Claudio Mussolino ◽  
Jamal Alzubi ◽  
Eli J. Fine ◽  
Robert Morbitzer ◽  
Thomas J. Cradick ◽  
...  
Keyword(s):  
Genome Editing ◽  
High Specificity ◽  
Human Cells ◽  
Low Cytotoxicity
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