Aktinische Keratose: Drei therapeutische Verfahren im direkten Vergleich

2021 ◽  
pp. 1-2
Author(s):  
Percy Lehmann
Keyword(s):  
Performance Index ◽  
High Frequency ◽  
Treatment Options ◽  
High Frequency Ultrasound ◽  
Treatment Area ◽  
Before And After ◽  
Therapeutische Verfahren ◽  
Surrounding Skin ◽  
Perilesional Skin ◽  
Frequency Ultrasound

<b>Background:</b> The efficacy for actinic keratosis (AK) clearance of field-directed treatments has been investigated in randomized studies against placebo, but the comparison of results is difficult for several methodological reasons. <b>Objectives:</b> The present study aims to compare efficacy of MAL-photodynamic therapy (MAL-PDT), ingenol mebutate gel (IMB) and diclofenac plus hyaluronate gel (DHA) on multiple AKs assessing a new performance index of efficacy, the cumulative AK area and evaluating dermoscopical and high-frequency ultrasound (HFUS) changes. <b>Methods:</b> Patients with ≥5 Olsen II AKs in a 25 cm2 area of the scalp and face were enrolled and randomized to one of the treatment choices. Number of AKs and cumulative area were assessed before and after treatment. Dermoscopy and HFUS were performed on a single AK and surrounding photo-damaged skin in the treatment area. <b>Results:</b> Cumulative AKs area reduced significantly more with PDT compared to other treatment options and with IMB in comparison to DHA. PDT was also the only treatment option that increased at a significant level the dermal density in both target AK and the surrounding skin and decreased significantly the SLEB thickness in the perilesional skin at HFUS. <b>Conclusions:</b> MAL-PDT is more effective than IMB and DHA for reducing the cumulative AK area which is calculated digitally from 3D pictures and should be the preferred performance index for the evaluation of the efficacy of treatments for AKs, rolling out clinical and dermoscopy evaluation. MAL-PDT improves all HFUS features of chronic photodamages of the dermis of the skin underlying and surrounding the AK spots.

scholarly journals The potential of high-frequency ultrasound Dopplerography in the assessment of microcirculatory disorders in post-COVID-19 patients with a cardiovascular profile

2022 ◽  
Vol 20 (4) ◽  
pp. 101-105
Author(s):  
Yu. S. Andozhskaya
Keyword(s):  
Blood Flow ◽  
High Frequency ◽  
Spectral Characteristics ◽  
Preventive Therapy ◽  
High Frequency Ultrasound ◽  
Group I ◽  
Before And After ◽  
Microcirculatory Disorders ◽  
Cardiovascular Profile ◽  
Frequency Ultrasound

Introduction. Patients with cardiovascular diseases have endothelial dysfunction and a higher risk of severe course of COVID-19, and thrombotic complications. Associated endotheliitis caused by virus penetration and cytokines storm leads to the release of tissue factor, the formation of excess thrombin and fibrin and thrombosis. The aim. To identify the potential of high-frequency ultrasound Dopplerography (HFUDG) for the assessment of microcirculatory disorders in post-COVID-19 patients with cardiovascular profile and to assess the microcirculatory bed condition before and after treatment with sulodexide. Materials and methods. 49 patients recovered from moderate-severe COVID-19 one month ago, aged 20–80, were examined. 24 patients, received prophylaxis with POACs for 1 month, formed group I, group II – 25 patients without prophylaxis. The nail bed of the upper limb 1st finger was examined using HFUDG and a 25 MHz sensor. Shape and spectrum of curves taken from dopplerograms were analyzed. The control examination was performed 4 weeks after therapy. Results. In patients after COVID19, depletion of spectral characteristics was revealed in comparison with dopplerograms of healthy individuals. The predominantly red part of the spectrum corresponding to the fastest particles was recorded. Slow-moving particles corresponding to the lighter part of the spectrum were nearly non-existent. In patients administrated POAC prophylaxis, amplitude indices were higher. Significant increase in D-dimer, antithrombin III, and soluble fibrin monomer complexes (SFMC) was also detected. The remaining parameters of the coagulogram were within the norm before and after treatment. After a course of sulodexide therapy, the spectral characteristics and coagulogram parameters returned to normal. Conclusion. HFUDG allows to detect stasis of capillary blood flow, the appearance of shunt blood flow corresponding to microtrombosis. Microcirculation indicators in post-COVID-19 patients improved after a course of preventive therapy with sulodexide.

Clinical Application of High Frequency Ultrasound in Diagnosis and Treatment of Lumbar Muscle Injury After Strenuous Exercise

2020 ◽  
Vol 10 (4) ◽  
pp. 923-927
Author(s):  
Weihong Wang ◽  
Xiaojun Wang
Keyword(s):  
Pain Score ◽  
High Frequency ◽  
Muscle Injury ◽  
Gluteus Medius ◽  
Strenuous Exercise ◽  
High Frequency Ultrasound ◽  
Dorsal Muscle ◽  
Before And After ◽  
Lumbar Muscle ◽  
Frequency Ultrasound

The purpose of this study was to analyze the clinical application of high-frequency ultrasound in the diagnosis and treatment of lumbar muscle injury after strenuous exercise. In this study, high-frequency ultrasound imaging technology was used to examine the patients' lumbar and dorsal position, and ultrasound examination was performed on the affected side and the healthy side of lumbar dorsal muscle before and after treatment. According to the thickness of abdomen transverse muscle, psoas muscle, lumbar muscle, gluteus medius revealed by ultrasound, as well as the visual analogue scale (VAS) pain score and J0A low back pain score, the rehabilitation of patients was analyzed. Through the observation of ultrasound images, it was found that the thickness of the transverse abdominis, lumbar maximus, quadratus lumborum muscle and gluteus medius on the affected side was significantly improved after treatment, the average VAS pain score was significantly decreased, and the average JOA lower back pain score was significantly increased, indicating that the patient's condition was significantly improved after treatment. The use of high-frequency ultrasound to detect the disease status before and after treatment can accurately understand the course of the disease and the curative effect after treatment. In a word, high-frequency ultrasound has a great clinical effect on patients with lumbar dorsal muscle injury.

scholarly journals Photodynamic Therapy Using HMME for Port-Wine Stains: Clinical Effectiveness and Sonographic Appearance

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Ahmad Taha Khalaf ◽  
Yonghong Sun ◽  
Fang Wang ◽  
Minmin Sheng ◽  
Yan Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Efficacy ◽  
High Frequency ◽  
Skin Thickness ◽  
Port Wine ◽  
High Frequency Ultrasound ◽  
Port Wine Stains ◽  
Irradiation Energy ◽  
Before And After ◽  
Frequency Ultrasound

This study aims at exploring the clinical efficacy and sonographic changes of photodynamic therapy (PDT) using Hematoporphyrin Monomethyl Ether (HMME) for the treatment of port-wine stains (PWS). Forty-five patients with PWS were recruited between March 2017 and June 2018 from the Department of Dermatology of The Third Affiliated Hospital of Soochow University. Five cases were of the pink type, thirty-nine cases were of the purple-red type, and one case was of the thickened type. All patients received three treatment sessions of PDT. After covering normal skin outside the treated area, patients received an intravenous injection of 5 mg/kg HMME within 20 minutes. The affected areas were exposed to a 532 nm LED light and were kept vertically at a distance of 10 cm. The irradiation energy density was set between 80 and 110 J/cm2 in 15-minute sessions. Intermittent power density adjustment was performed at a rate of 5 mW/cm2, and the treatment was withheld when the endpoint reaction appeared. Three follow-ups were performed before and after treatment, respectively, and the efficacy, thickness, and density of skin before and after treatment were evaluated with high-frequency ultrasound. The overall efficacy rate was 97.78% in forty-five cases after treatment for three sessions. Efficacy was related to age (P=0.029) and lesion severity (P<0.001). There were significant differences in the efficacy between the groups of <18 years old, 18-29 years old, and >29 years old (P=0.029). A marked decrease in the numbers of distorted enlarged blood vessels per unit of the lesion was observed under high-frequency ultrasound. There were significant differences in skin thickness and skin density before and after treatment (F=14.528, 5.428, P<0.001). The swelling was reported to varying degrees in the treated areas in 23 patients with cheek lesion and in 6 frontal lesions. Hyperpigmentation after inflammation was observed in four patients that faded spontaneously after two months. In conclusion, photodynamic therapy for the treatment of PWS using HMME is effective and safe with few adverse reactions. Moreover, monitoring the changes in skin thickness and density of lesion tissue using high-frequency ultrasound can objectively evaluate the clinical efficacy of HMME photodynamic therapy and provide the basis for the formulation of individualized photodynamic therapy.

scholarly journals Effectiveness of high frequency ultrasound on pressure ulcer

Medicine ◽  
2019 ◽  
Vol 98 (37) ◽  
pp. e17111 ◽  
Author(s):  
Xiang-qin Gao ◽  
Xiao-mei Xue ◽  
Jian-kang Zhang ◽  
Fei Yan ◽  
Qiu-xia Mu
Keyword(s):  
Pressure Ulcer ◽  
High Frequency ◽  
High Frequency Ultrasound ◽  
Frequency Ultrasound

Evaluation of frontal fibrosing alopecia with ultra‐high‐frequency ultrasound

2021 ◽  
Author(s):  
Carolina Ávila de Almeida ◽  
Simone Guarçoni ◽  
Bruna Duque Estrada ◽  
Maria Carolina Zafra Páez ◽  
Clarissa Canella
Keyword(s):  
High Frequency ◽  
High Frequency Ultrasound ◽  
Ultra High Frequency ◽  
Frequency Ultrasound
Sign in / Sign up

Export Citation Format

Share Document