scholarly journals Isolated Cervical Myelitis in Lyme Disease: A Rare Manifestation of Acute Neuroborreliosis

2020 ◽  
Vol 12 (3) ◽  
pp. 276-281
Author(s):  
Maren Hieber ◽  
Johann Lambeck ◽  
Sebastian Rauer ◽  
Juergen Bardutzky
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Clinical Symptoms ◽  
Neurological Manifestation ◽  
Imaging Findings ◽  
Early Stages ◽  
System Disease ◽  
Rare Manifestation ◽  
Strong Contrast

Neuroborreliosis is the neurological manifestation of Lyme disease, a tick-borne infectious multi-system disease caused by <i>Borrelia burgdorferi</i> sensu lato. It appears in 3 to 15% of all cases of acute Lyme disease, and includes meningitis, cranial neuritis, and painful radiculoneuritis as the most common manifestations. We report a case of acute neuroborreliosis that manifested as extended isolated cervical myelitis. Not only the manifestation as isolated myelitis in the early stages of borreliosis represents a rarity, but also the strong contrast between mild clinical symptoms and pronounced imaging findings in this case is remarkable.

scholarly journals Imaging of Lyme Neuroborreliosis: A Pictorial Review

2020 ◽  
Vol 7 (10) ◽  
Author(s):  
Adam Garkowski ◽  
Urszula Łebkowska ◽  
Bożena Kubas ◽  
Ewa Garkowska ◽  
Katarzyna Rutka ◽  
...  
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Focal Point ◽  
Neurological Manifestation ◽  
Lyme Neuroborreliosis ◽  
Imaging Findings ◽  
Pictorial Review ◽  
Spine Imaging ◽  
Lymphocytic Meningitis

Abstract Lyme neuroborreliosis is a common feature of Borrelia burgdorferi infection (as a neurological manifestation occurring in 10%–15% of all Lyme disease cases) and may involve any part of the nervous system, and its coverings, but usually manifests as lymphocytic meningitis, cranial neuritis, and/or radiculoneuritis. This review describes the imaging findings in Lyme neuroborreliosis: the focal point is on the manifestations of involvement visible on brain and spine imaging.

scholarly journals Lyme disease: New knowledge regarding its physiopathology, diagnosis, therapy and prevention

2002 ◽  
Vol 55 (5-6) ◽  
pp. 207-212
Author(s):  
Jovan Vukadinov ◽  
Sinisa Sevic ◽  
Grozdana Canak ◽  
Nadezda Madle-Samardzija ◽  
Vesna Turkulov ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Antigenic Variation ◽  
Clinical Symptoms ◽  
Epidemiological Studies ◽  
Lyme Arthritis ◽  
Major Protein ◽  
Selective Treatment ◽  
Multisystem Disease ◽  
New Guidelines

Introduction Lyme disease is a tick-borne disease caused by a spirochete Borrelia burgdorferi, which manifests as a multisystem disease of the skin nervous system, heart and joints. Recently it is the most common vector-borne disease in Yugoslavia. New epidemiological studies New epidemiological studies revealed that ticks can occasionally be infected not only by Borrelia burgdorferi, but also by some other microbes that can cause diseases in humans. Recently discovered the variable major protein-like sequence, antigenic variation of B. burgdorferi B 31 partly explains the ability of this organism to evade an active immune response. A key role in development of clinical symptoms associated with lyme disease belongs to the connection with ability of B. burgdorferi to induce and activate metallopeptidases and fibrinolytic enzymes, leading to extracellular matrix destruction. Diagnosis and treatment Diagnosis of Lyme borreliosis is made on the basis of clinical picture, exposure to ticks in endemic areas and serologic confirmation. It seems that polymerase chain reaction has little role in detection of B. burgdorferi in urine, blood, and spinal fluid samples, but it is most useful in evaluating the effectiveness of antibiotic therapy of Lyme arthritis. Infectious Diseases Society of America had prepared new guidelines for selective treatment of Lyme disease. Vaccination is still the best way of prevention for people living in high-risk areas.

scholarly journals Neuroborreliosis – clinical presentation – Current state of knowledge

2019 ◽  
pp. 321-328 ◽  
Author(s):  
Katarzyna Krawczuk ◽  
Piotr Czupryna ◽  
Sławomir Pancewicz ◽  
Elżbieta Ołdak ◽  
Monika Król ◽  
...  
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Peripheral Nervous System ◽  
Clinical Presentation ◽  
Clinical Symptoms ◽  
Clinical Course ◽  
Tick Bites ◽  
Current State ◽  
Adults And Children

Neuroborreliosis is one of the manifestations of Lyme disease involving central and peripheral nervous system. It is caused by infection with Borrelia burgdorferi spirochete which is transmitted by tick bites. Neuroborreliosis can affect both adults and children. The clinical course in children is often different than in adults. The article discusses the most common clinical symptoms, complications, diagnostics and treatment of neuroborreliosis in children.

scholarly journals Lyme disease: The great imitator

2007 ◽  
Vol 23 (5-6-2) ◽  
pp. 215-221
Author(s):  
S. Savic-Jevdjenic ◽  
Z. Grgic ◽  
B. Vidic ◽  
A. Petrovic
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Clinical Symptoms ◽  
Domestic Animals ◽  
Dark Field ◽  
Tick Population ◽  
Seropositive Animal ◽  
Different Populations ◽  
Fixation Reaction

Lyme disease, or Lyme borreliosis can occur in domestic animals and in people, with no characteristic symptoms. That is why Lyme disease is often diagnosed and treated as some other disease. Clinical symptoms of this disease are not specific and they can look like a number of different diseases, which is why the disease is called - the great imitator. The reservoirs of the disease are ticks Ixodes ricinus. During the research from 2005 to 2007 it was established that the prevalence with Lyme borreliosis exists within the tick population. The objective of this paper is a survey of the presence of Lyme disease in different populations of different animal species (horses, cattle, sheep and dogs) in the region where the infection of ticks with Borrelia burgdorferi was established in the percentage of 25-28%. The methods used were the ones for the determination of Borrelia burgdorferi in ticks, with a dark field microscopy, and also the presence of antibodies against Borrelia burgdorferi was determinate with a complement fixation reaction, in the blood sera of horses, sheep, cattle and dogs. As the result it was found that the cause of Lyme disease, Borrelia burgdorferi is constantly present within the tick population. In examined horses and cattle the presence of antibodies against B. burgdorferi was not found, while in sheep and dogs, the presence of antibodies was found. Any seropositive animal, and also an infected tick, represents a danger for the human population and also for other animals, which are in the surrounding. Lyme disease is usually not mortal, but it can create a lot of problems leading to the decrease of production in domestic animals or an illness with clinical symptoms in humans, horses and dogs.

Profil pacjenta diagnozowanego w kierunku boreliozy na przykładzie pacjentów szpitala pediatrycznego Warszawskiego Uniwersytetu Medycznego w latach 2013-2015

2018 ◽  
Vol 22 (1) ◽  
Author(s):  
Małgorzata Badełek-Izdebska ◽  
Małgorzata Dębska ◽  
Lidia Zawadzka-Głos
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Clinical Symptoms ◽  
Elisa Test ◽  
Facial Nerve Paralysis ◽  
Pediatric Hospital ◽  
Serological Tests ◽  
Nerve Paralysis ◽  
History Of ◽  
Medical University

Introduction. Lyme borreliosis is the most frequent tick-borne disease in Europe and North America. It is a chronic, multi-organ disease, with phasic course. The diagnosis is based on clinical symptoms and serologic findings at the patient bitten by the tick. Aim. Aim of this study was to analyze the recommendations for the tests towards the Lyme disease at patients of the Pediatric Hospital of Medical University of Warsaw. Material and methods. We conducted a retrospective analysis of medical data of children hospitalized at the Pediatric Hospital in the period from January 2013 to the end of February 2015, who had performed diagnostic tests for Borrelia burgdorferi infection. Results. In the period from 1st January 2013 to 28th February 2015 tests forantibodies to Borrelia burgdorferi were ordered in 226 patients, including 119 girls and 107 boys. The ELISA test was performed in 219 patients, Western blot test was performed in 25 patients, and the presence of antibodies in the cerebrospinal fluid was examined in 2 patients. Diagnosed patients presented various symptoms. Patients from the two largest groups reported with articular complaints and heart symptoms. The group of patients diagnosed with fever, headache and facial nerve paralysis was less numerous. A small group of patients had a history of tick bite and presented with erythema. Conclusions. Patients of the Pediatric Hospital of the Medical University of Warsaw, who were ordered to perform tests for Lyme disease, presented symptoms from various organs and systems. These symptoms overlap with ailments and symptoms described in people who have been diagnosed with Lyme disease in both the early and late stages of the disease. The serological tests in connection with the medical history and physical examination are an important element in the diagnostics of Lyme disease in children.

Atypical papillitis: An isolated manifestation of Lyme disease

2019 ◽  
Vol 30 (5) ◽  
pp. NP46-NP52
Author(s):  
Lucia Mata-Moret ◽  
Carolina Garcia-Villanueva ◽  
Clara Monferrer-Adsuara ◽  
Veronica Castro Navarro ◽  
Enrique Cervera-Taulet
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Skin Rash ◽  
Endemic Area ◽  
Rare Condition ◽  
Indirect Test ◽  
Physician Consultation ◽  
Early Stages

Lyme disease is a rare condition caused by the bacterium Borrelia burgdorferi. Despite typical symptoms including fever, headache, fatigue, and a characteristic skin rash, sometimes we cannot find those due to the lack of physician consultation in those early stages. If this disease is left untreated, infection could spread to the nervous system causing neuroborreliosis, an atypical and complicated manifestation of this disease. We present the case of an atypical papillitis, probably caused by this bacterium. We suspected this because of the results on the indirect test bloods and the improvement of the symptoms after treatment. This entity should be considered as a possible diagnosis of atypical optical neuropathies, particularly if it occurs in an endemic area.

scholarly journals Evaluation of Selected Borrelia burgdorferi lp54 Plasmid-Encoded Gene Products Expressed during Mammalian Infection as Antigens To Improve Serodiagnostic Testing for Early Lyme Disease

2015 ◽  
Vol 22 (11) ◽  
pp. 1176-1186 ◽  
Author(s):  
Zachary P. Weiner ◽  
Rebecca M. Crew ◽  
Kevin S. Brandt ◽  
Amy J. Ullmann ◽  
Martin E. Schriefer ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Recombinant Proteins ◽  
Erythema Migrans ◽  
Disease Patient ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Samples ◽  
Early Stages ◽  
Lyme Carditis ◽  
Mammalian Infection

ABSTRACTLaboratory testing for the diagnosis of Lyme disease is performed primarily by serologic assays and is accurate for detection beyond the acute stage of the infection. Serodiagnostic assays to detect the early stages of infection, however, are limited in their sensitivity, and improvement is warranted. We analyzed a series ofBorrelia burgdorferiproteins known to be induced within feeding ticks and/or during mammalian infection for their utility as serodiagnostic markers against a comprehensive panel of Lyme disease patient serum samples. The antigens were assayed for IgM and IgG reactivity in line immunoblots and separately by enzyme-linked immunosorbent assay (ELISA), with a focus on reactivity against early Lyme disease with erythema migrans (EM), early disseminated Lyme neuroborreliosis, and early Lyme carditis patient serum samples. By IgM immunoblotting, we found that recombinant proteins BBA65, BBA70, and BBA73 reacted with early Lyme EM samples at levels comparable to those of the OspC antigen used in the current IgM blotting criteria. Additionally, these proteins reacted with serum samples from patients with early neuroborreliosis and early carditis, suggesting value in detecting early stages of this disease progression. We also found serological reactivity against recombinant proteins BBA69 and BBA73 with early-Lyme-disease samples using IgG immunoblotting and ELISA. Significantly, some samples that had been scored negative by the Centers for Disease Control and Prevention-recommended 2-tiered testing algorithm demonstrated positive reactivity to one or more of the antigens by IgM/IgG immunoblot and ELISA. These results suggest that incorporating additionalin vivo-expressed antigens into the current IgM/IgG immunoblotting tier in a recombinant protein platform assay may improve the performance of early-Lyme-disease serologic testing.

New ultrastructural findings about Borrelia burgdorferi by cryofixation, negative staining, thin sectioning and scanning techniques

1990 ◽  
Vol 48 (3) ◽  
pp. 582-583
Author(s):  
S. F. Hayes ◽  
M. D. Corwin ◽  
T. G. Schwan ◽  
D. W. Dorward ◽  
W. Burgdorfer
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Structural Characterization ◽  
Negative Staining ◽  
Low Speed ◽  
Thin Sectioning ◽  
Ultrastructural Findings

Characterization of Borrelia burgdorferi strains by means of negative staining EM has become an integral part of many studies related to the biology of the Lyme disease organism. However, relying solely upon negative staining to compare new isolates with prototype B31 or other borreliae is often unsatisfactory. To obtain more satisfactory results, we have relied upon a correlative approach encompassing a variety EM techniques, i.e., scanning for topographical features and cryotomy, negative staining and thin sectioning to provide a more complete structural characterization of B. burgdorferi.For characterization, isolates of B. burgdorferi were cultured in BSK II media from which they were removed by low speed centrifugation. The sedimented borrelia were carefully resuspended in stabilizing buffer so as to preserve their features for scanning and negative staining. Alternatively, others were prepared for conventional thin sectioning and for cryotomy using modified procedures. For thin sectioning, the fixative described by Ito, et al.

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