scholarly journals Lyme disease: The great imitator

2007 ◽  
Vol 23 (5-6-2) ◽  
pp. 215-221
Author(s):  
S. Savic-Jevdjenic ◽  
Z. Grgic ◽  
B. Vidic ◽  
A. Petrovic
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Clinical Symptoms ◽  
Domestic Animals ◽  
Dark Field ◽  
Tick Population ◽  
Seropositive Animal ◽  
Different Populations ◽  
Fixation Reaction

Lyme disease, or Lyme borreliosis can occur in domestic animals and in people, with no characteristic symptoms. That is why Lyme disease is often diagnosed and treated as some other disease. Clinical symptoms of this disease are not specific and they can look like a number of different diseases, which is why the disease is called - the great imitator. The reservoirs of the disease are ticks Ixodes ricinus. During the research from 2005 to 2007 it was established that the prevalence with Lyme borreliosis exists within the tick population. The objective of this paper is a survey of the presence of Lyme disease in different populations of different animal species (horses, cattle, sheep and dogs) in the region where the infection of ticks with Borrelia burgdorferi was established in the percentage of 25-28%. The methods used were the ones for the determination of Borrelia burgdorferi in ticks, with a dark field microscopy, and also the presence of antibodies against Borrelia burgdorferi was determinate with a complement fixation reaction, in the blood sera of horses, sheep, cattle and dogs. As the result it was found that the cause of Lyme disease, Borrelia burgdorferi is constantly present within the tick population. In examined horses and cattle the presence of antibodies against B. burgdorferi was not found, while in sheep and dogs, the presence of antibodies was found. Any seropositive animal, and also an infected tick, represents a danger for the human population and also for other animals, which are in the surrounding. Lyme disease is usually not mortal, but it can create a lot of problems leading to the decrease of production in domestic animals or an illness with clinical symptoms in humans, horses and dogs.

scholarly journals Tube Phagocytosis, a Novel Way for Neutrophils To Phagocytize Borrelia burgdorferi

1998 ◽  
Vol 66 (7) ◽  
pp. 3433-3435 ◽  
Author(s):  
Juha Suhonen ◽  
Kaija Hartiala ◽  
Matti K. Viljanen
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Dark Field ◽  
Human Neutrophils ◽  
Video Technology ◽  
Dark Field Microscopy

ABSTRACT Interactions between human neutrophils and Borrelia burgdorferi, the Lyme disease spirochete, were studied by dark-field microscopy combined with video technology. A previously unrecognized mechanism for neutrophils to phagocytize the spirochete was discovered. During phagocytosis, the spirochete attaches to the neutrophil head-on, the neutrophil forms a thin tubelike protrusion around the bacterium, and the fully covered spirochete is drawn into the cell.

scholarly journals Lyme disease: New knowledge regarding its physiopathology, diagnosis, therapy and prevention

2002 ◽  
Vol 55 (5-6) ◽  
pp. 207-212
Author(s):  
Jovan Vukadinov ◽  
Sinisa Sevic ◽  
Grozdana Canak ◽  
Nadezda Madle-Samardzija ◽  
Vesna Turkulov ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Antigenic Variation ◽  
Clinical Symptoms ◽  
Epidemiological Studies ◽  
Lyme Arthritis ◽  
Major Protein ◽  
Selective Treatment ◽  
Multisystem Disease ◽  
New Guidelines

Introduction Lyme disease is a tick-borne disease caused by a spirochete Borrelia burgdorferi, which manifests as a multisystem disease of the skin nervous system, heart and joints. Recently it is the most common vector-borne disease in Yugoslavia. New epidemiological studies New epidemiological studies revealed that ticks can occasionally be infected not only by Borrelia burgdorferi, but also by some other microbes that can cause diseases in humans. Recently discovered the variable major protein-like sequence, antigenic variation of B. burgdorferi B 31 partly explains the ability of this organism to evade an active immune response. A key role in development of clinical symptoms associated with lyme disease belongs to the connection with ability of B. burgdorferi to induce and activate metallopeptidases and fibrinolytic enzymes, leading to extracellular matrix destruction. Diagnosis and treatment Diagnosis of Lyme borreliosis is made on the basis of clinical picture, exposure to ticks in endemic areas and serologic confirmation. It seems that polymerase chain reaction has little role in detection of B. burgdorferi in urine, blood, and spinal fluid samples, but it is most useful in evaluating the effectiveness of antibiotic therapy of Lyme arthritis. Infectious Diseases Society of America had prepared new guidelines for selective treatment of Lyme disease. Vaccination is still the best way of prevention for people living in high-risk areas.

scholarly journals Lyme borreliosis: Europe-wide coordinated surveillance and action needed?

2006 ◽  
Vol 11 (25) ◽  
Author(s):  
R. Smith ◽  
J Takkinen ◽  
Collective Editorial team
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Lyme Borreliosis

Lyme borreliosis (Lyme disease) is an infection caused by the spirochete bacteria Borrelia burgdorferi

scholarly journals AWARENESS OF LYME BORRELIOSIS OF THE PATIENTS OF TERNOPIL REGIONAL TB DISPENSARY

2017 ◽  
Author(s):  
L. P. Melnyk ◽  
L. A. Hryshchuk ◽  
M. Koziol–Montewka ◽  
P. S. Tabas ◽  
R. O. Klos
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Preventive Measures ◽  
Epidemiological Data ◽  
Sufficient Information ◽  
Tick Bites ◽  
The World ◽  
History Of

Background. Lyme disease has many clinical features similar tothose in sarcoidosis and tuberculosis. Epidemiological data in the world, in particular in Ukraine, proves the increase in Lyme borreliosis incidence. Ternopil region is endemic with Lyme borreliosis.Objective. The research was aimed to investigate the prevalence of infection with Borrelia burgdorferi and epidemiology features of borreliosis among the patients of Ternopil Regional TB Dispensary.Methods. In total, 29 patients were admitted to Departments of Differential Diagnostic, TB Therapy and TB Surgery of Ternopil Regional TB Dispensary in October 2016-January 2017. All the surveyed answered the questions of an integrated international questionnaire, where they noted the area and a number of tick bites, described the removal method, noted the survey for borreliosis pathogen and complaints after tick bites.Results. It was established that 5 respondents had a history of tick bites episodes, but only in one case the patient was examined of borreliosis. Tick bites were noticed in 3 patients with sarcoidosis and 1 with tuberculosis (TB) and exudative pleurisy, respectively.Conclusions. The absence of appeals for medical care, lack of sufficient information on Lyme borreliosis and disuse of preventive measures for tick bites by the interviewed patients of Ternopil regional TB dispensary departments proves the need of improvement of health education on Lyme borreliosis (LB) among this category of population. 24 (82.7%) of 29 respondents did not remember the tick bite. The symptoms of (LB) are similar to those in sarcoidosis and tuberculosis (pleural lesions, heart, joints, nervous system, skin), and the presence of tick bites gives the reasons to examine these patients of Borrelia burgdorferi senso lato.

scholarly journals Serum Complement Sensitivity as a Key Factor in Lyme Disease Ecology

1998 ◽  
Vol 66 (3) ◽  
pp. 1248-1251 ◽  
Author(s):  
Klaus Kurtenbach ◽  
Henna-Sisko Sewell ◽  
Nick H. Ogden ◽  
Sarah E. Randolph ◽  
Patricia A. Nuttall
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Disease Ecology ◽  
Specific Pattern ◽  
Serum Complement ◽  
Key Factor ◽  
Species Specific

ABSTRACT The sensitivity of Borrelia burgdorferi sensu lato to animal sera was analyzed. Complement-mediated borreliacidal effects were observed with particular combinations of host serum andBorrelia genospecies. The species-specific pattern of viability and/or lysis is highly consistent with the pattern of reservoir competence of hosts for B. burgdorferi sensu lato, suggesting a key role of complement in the global ecology of Lyme borreliosis.

scholarly journals Neuroborreliosis – clinical presentation – Current state of knowledge

2019 ◽  
pp. 321-328 ◽  
Author(s):  
Katarzyna Krawczuk ◽  
Piotr Czupryna ◽  
Sławomir Pancewicz ◽  
Elżbieta Ołdak ◽  
Monika Król ◽  
...  
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Peripheral Nervous System ◽  
Clinical Presentation ◽  
Clinical Symptoms ◽  
Clinical Course ◽  
Tick Bites ◽  
Current State ◽  
Adults And Children

Neuroborreliosis is one of the manifestations of Lyme disease involving central and peripheral nervous system. It is caused by infection with Borrelia burgdorferi spirochete which is transmitted by tick bites. Neuroborreliosis can affect both adults and children. The clinical course in children is often different than in adults. The article discusses the most common clinical symptoms, complications, diagnostics and treatment of neuroborreliosis in children.

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