scholarly journals Rapidly and Slowly Growing Lineages in Chromosomal Instability-Type Gland-Forming Gastric Carcinomas as Revealed by Multisampling Analysis of DNA Copy-Number Profile

Pathobiology ◽  
2019 ◽  
Vol 86 (2-3) ◽  
pp. 118-127 ◽  
Author(s):  
Tu Thanh Duong ◽  
Diem Thi-Ngoc Vo ◽  
Takahisa Nakayama ◽  
Ken-ichi Mukaisho ◽  
Masamichi Bamba ◽  
...  
Keyword(s):  
Copy Number ◽  
Chromosomal Instability ◽  
Copy Number Profile ◽  
Dna Copy Number ◽  
Gastric Carcinomas

Comprehensive DNA copy number profile and BAC library construction of an Indian individual

Gene ◽  
2012 ◽  
Vol 500 (2) ◽  
pp. 186-193 ◽  
Author(s):  
Sanjiban Chakrabarty ◽  
Reena R. D'Souza ◽  
Ravishankara Bellampalli ◽  
Harish Rotti ◽  
Abdul V. Saadi ◽  
...  
Keyword(s):  
Copy Number ◽  
Bac Library ◽  
Copy Number Profile ◽  
Dna Copy Number ◽  
Library Construction

EZH2 is overexpressed in breast tumors with a BRCA1-like DNA copy number profile

2015 ◽  
Vol 12 (02) ◽  
Author(s):  
J Puppe ◽  
M Opdam ◽  
P Schouten ◽  
P Mallmann ◽  
S Rodenhuis ◽  
...  
Keyword(s):  
Copy Number ◽  
Breast Tumors ◽  
Copy Number Profile ◽  
Dna Copy Number

EZH2 is overexpressed in breast tumors with a BRCA1-like DNA copy number profile

2016 ◽  
Vol 76 (10) ◽  
Author(s):  
J Puppe ◽  
M Opdam ◽  
K Jozwiak ◽  
PC Schouten ◽  
S Rodenhuis ◽  
...  
Keyword(s):  
Copy Number ◽  
Breast Tumors ◽  
Copy Number Profile ◽  
Dna Copy Number

scholarly journals Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components

2006 ◽  
Vol 28 (5-6) ◽  
pp. 283-294
Author(s):  
Beatriz Carvalho ◽  
Tineke E. Buffart ◽  
Rui M. Reis ◽  
Thomas Mons ◽  
Cátia Moutinho ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chromosomal Aberrations ◽  
Copy Number ◽  
Array Cgh ◽  
Comparative Genomic Hybridisation ◽  
Comparative Genomic ◽  
Dna Copy Number ◽  
Gastric Carcinomas ◽  
Phenotypic Divergence ◽  
Copy Number Changes

Gastric cancer is one of the most frequent malignancies in the world. Nonetheless, the knowledge of the molecular events involved in the development of gastric carcinoma is far from complete. One of the hallmarks of gastric cancer is chromosomal instability resulting in abnormal DNA copy number changes throughout the genome. Mixed gastric carcinomas constitute a rare histological entity, containing the two main histological phenotypes (diffuse and intestinal). Very little is known about the underlying mechanisms of phenotypic divergence in these mixed tumours. To the best of our knowledge only E-Cadherin mutations were implicated so far in the divergence of these tumours and nothing is known about the involvement of chromosome copy number changes in the two divergent histological components. In this study, we compared the DNA copy number changes, in the two different components (diffuse and intestinal) of mixed gastric carcinomas by microarray – comparative genomic hybridisation (array CGH). The analysis of 12 mixed gastric carcinomas showed no significant differences in array CGH profiles between the diffuse and intestinal components of mixed carcinomas. This supports the idea that the phenotypic divergence within mixed gastric carcinomas is not caused by DNA chromosomal aberrations.

DNA copy number profiling reveals different patterns of chromosomal instability within colorectal cancer according to the age of onset

2015 ◽  
Vol 55 (5) ◽  
pp. 705-716 ◽  
Author(s):  
María Arriba ◽  
Juan L. García ◽  
Lucía Inglada-Pérez ◽  
Daniel Rueda ◽  
Irene Osorio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Copy Number ◽  
Chromosomal Instability ◽  
Age Of Onset ◽  
Dna Copy Number
Sign in / Sign up

Export Citation Format

Share Document