DNA copy number profiling reveals different patterns of chromosomal instability within colorectal cancer according to the age of onset

2015 ◽  
Vol 55 (5) ◽  
pp. 705-716 ◽  
Author(s):  
María Arriba ◽  
Juan L. García ◽  
Lucía Inglada-Pérez ◽  
Daniel Rueda ◽  
Irene Osorio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Copy Number ◽  
Chromosomal Instability ◽  
Age Of Onset ◽  
Dna Copy Number

DNA copy number alterations, gene expression changes and disease-free survival in patients with colorectal cancer: a 10 year follow-up

2016 ◽  
Vol 39 (6) ◽  
pp. 545-558 ◽  
Author(s):  
Elisabetta Bigagli ◽  
Carlotta De Filippo ◽  
Cinzia Castagnini ◽  
Simona Toti ◽  
Francesco Acquadro ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Copy Number ◽  
Disease Free Survival ◽  
Copy Number Alterations ◽  
Dna Copy Number ◽  
Free Survival ◽  
Dna Copy Number Alterations ◽  
Disease Free

Abstract 4281: Mitochondrial DNA copy number, urinary isoprostanes and colorectal cancer risk

2016 ◽  
Author(s):  
Bharat Thyagarajan ◽  
Renwei Wang ◽  
Woon-Puay Koh ◽  
Helene Barcelo ◽  
Jennifer Adams-Haduch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Cancer Risk ◽  
Copy Number ◽  
Colorectal Cancer Risk ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

scholarly journals Association between pre-diagnostic leukocyte mitochondrial DNA copy number and survival among colorectal cancer patients

2020 ◽  
Vol 68 ◽  
pp. 101778
Author(s):  
Keming Yang ◽  
Michele R. Forman ◽  
Brett H. Graham ◽  
Patrick O. Monahan ◽  
Edward L. Giovannucci ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Cancer Patients ◽  
Copy Number ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number ◽  
Colorectal Cancer Patients

scholarly journals Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
GiWon Shin ◽  
Stephanie U. Greer ◽  
Erik Hopmans ◽  
Susan M. Grimes ◽  
HoJoon Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Copy Number ◽  
Chromosomal Instability ◽  
Tandem Repeats ◽  
Chromosome 8 ◽  
Driver Mutations ◽  
Colorectal Carcinomas ◽  
Mixed States ◽  
Chromosome Arm

AbstractWe developed a sensitive sequencing approach that simultaneously profiles microsatellite instability, chromosomal instability, and subclonal structure in cancer. We assessed diverse repeat motifs across 225 microsatellites on colorectal carcinomas. Our study identified elevated alterations at both selected tetranucleotide and conventional mononucleotide repeats. Many colorectal carcinomas had a mix of genomic instability states that are normally considered exclusive. An MSH3 mutation may have contributed to the mixed states. Increased copy number of chromosome arm 8q was most prevalent among tumors with microsatellite instability, including a case of translocation involving 8q. Subclonal analysis identified co-occurring driver mutations previously known to be exclusive.

scholarly journals Mitochondrial DNA copy number in colorectal cancer: between tissue comparisons, clinicopathological characteristics and survival

2015 ◽  
pp. bgv151 ◽  
Author(s):  
Frits H.M. van Osch ◽  
An M. Voets ◽  
Leo J. Schouten ◽  
Ralph W.H. Gottschalk ◽  
Colinda C.J.M. Simons ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Clinicopathological Characteristics ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number
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