scholarly journals DNA copy number aberrations associated with aneuploidy and chromosomal instability in breast cancers

2010 ◽  
Author(s):  
Kawauchi
Keyword(s):  
Copy Number ◽  
Chromosomal Instability ◽  
Breast Cancers ◽  
Dna Copy Number ◽  
Copy Number Aberrations ◽  
Dna Copy Number Aberrations

scholarly journals CMDS: a population-based method for identifying recurrent DNA copy number aberrations in cancer from high-resolution data

2009 ◽  
Vol 26 (4) ◽  
pp. 464-469 ◽  
Author(s):  
Qunyuan Zhang ◽  
Li Ding ◽  
David E. Larson ◽  
Daniel C. Koboldt ◽  
Michael D. McLellan ◽  
...  
Keyword(s):  
High Resolution ◽  
Copy Number ◽  
Population Based ◽  
Dna Copy Number ◽  
High Resolution Data ◽  
Copy Number Aberrations ◽  
Dna Copy Number Aberrations ◽  
Resolution Data

scholarly journals Development of a Genome-Wide Oligonucleotide Microarray Platform for Detection of DNA Copy Number Aberrations in Feline Cancers

2020 ◽  
Vol 7 (3) ◽  
pp. 88
Author(s):  
Rachael Thomas ◽  
Joan U Pontius ◽  
Luke B Borst ◽  
Matthew Breen
Keyword(s):  
Genome Sequence ◽  
Copy Number ◽  
Reference Genome ◽  
Microarray Platform ◽  
Domestic Cat ◽  
Dna Copy Number ◽  
Reference Genome Sequence ◽  
Copy Number Aberrations ◽  
Genome Sequence Assembly ◽  
Dna Copy Number Aberrations

The utility of the domestic cat as a model system for biomedical studies was constrained for many years by the absence of a comprehensive feline reference genome sequence assembly. While such a resource now exists, the cat continues to lag behind the domestic dog in terms of integration into the ‘One Health’ era of molecular medicine. Stimulated by the advances being made within the evolving field of comparative cancer genomics, we developed a microarray platform that allows rapid and sensitive detection of DNA copy number aberrations in feline tumors using comparative genomic hybridization analysis. The microarray comprises 110,456 unique oligonucleotide probes anchored at mean intervals of 22.6 kb throughout the feline reference genome sequence assembly, providing ~350-fold higher resolution than was previously possible using this technique. We demonstrate the utility of this resource through genomic profiling of a feline injection-site sarcoma case, revealing a highly disrupted profile of DNA copy number imbalance involving several key cancer-associated genes including KIT, TP53, PTEN, FAS and RB1. These findings were supported by targeted fluorescence in-situ hybridization analysis, which identified major alterations in chromosome structure, including complex intrachromosomal reorganization events typical of those seen in aggressive soft-tissue sarcomas of other species. We then characterized a second mass that was identified at a nearby site in the same patient almost 12 months later. This mass demonstrated a remarkably conserved genomic profile consistent with a recurrence of the original tumor; however the detection of subtle differences reflected evolution of the tumor over time. These findings exemplify the diverse potential of this microarray platform to incorporate domestic cat cancers into comparative and translational research efforts in molecular oncology.

scholarly journals Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

2011 ◽  
Vol 52 (7) ◽  
pp. 1321-1335 ◽  
Author(s):  
Rachael Thomas ◽  
Eric L. Seiser ◽  
Alison Motsinger-Reif ◽  
Luke Borst ◽  
Victor E. Valli ◽  
...  
Keyword(s):  
Copy Number ◽  
Dna Copy Number ◽  
Copy Number Aberrations ◽  
Dna Copy Number Aberrations
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