scholarly journals Pollenallergie gegen Ambrosia: Belastungen, Merkmale und Umgang mit einem importierten Allergieverursacher in Europa

2018 ◽  
Vol 6 (4) ◽  
pp. 206-207
Author(s):  
Claudia Traidl-Hoffmann
Keyword(s):  
Pollen Allergy ◽  
Ambrosia Artemisiifolia ◽  
Ragweed Pollen ◽  
Pollen Extract ◽  
Herbaceous Plant ◽  
Type I ◽  
Long Distance ◽  
Allergen Specific Immunotherapy ◽  
Major Health Problem ◽  
Amb A 1

Ambrosia artemisiifolia, also known as common or short ragweed, is an invasive annual flowering herbaceous plant that has its origin in North America. Nowadays, ragweed can be found in many areas worldwide. Ragweed pollen is known for its high potential to cause type I allergic reactions in late summer and autumn and represents a major health problem in America and several countries in Europe. Climate change and urbanization, as well as long distance transport capacity, enhance the spread of ragweed pollen. Therefore ragweed is becoming domestic in non-invaded areas which in turn will increase the sensitization rate. So far 11 ragweed allergens have been described and, according to IgE reactivity, Amb a 1 and Amb a 11 seem to be major allergens. Sensitization rates of the other allergens vary between 10 and 50%. Most of the allergens have already been recombinantly produced, but most of them have not been characterized regarding their allergenic activity, therefore no conclusion on the clinical relevance of all the allergens can be made, which is important and necessary for an accurate diagnosis. Pharmacotherapy is the most common treatment for ragweed pollen allergy but fails to impact on the course of allergy. Allergen-specific immunotherapy (AIT) is the only causative and disease-modifying treatment of allergy with long-lasting effects, but currently it is based on the administration of ragweed pollen extract or Amb a 1 only. In order to improve ragweed pollen AIT, new strategies are required with higher efficacy and safety.

scholarly journals Pollenallergie gegen Ambrosia: Belastungen, Merkmale und Umgang mit einem importierten Allergieverursacher in Europa

2019 ◽  
Vol 7 (2) ◽  
pp. 86-87
Author(s):  
Claudia Traidl-Hoffmann
Keyword(s):  
Pollen Allergy ◽  
Ambrosia Artemisiifolia ◽  
Ragweed Pollen ◽  
Pollen Extract ◽  
Herbaceous Plant ◽  
Type I ◽  
Long Distance ◽  
Allergen Specific Immunotherapy ◽  
Major Health Problem ◽  
Amb A 1

Ambrosia artemisiifolia, also known as common or short ragweed, is an invasive annual flowering herbaceous plant that has its origin in North America. Nowadays, ragweed can be found in many areas worldwide. Ragweed pollen is known for its high potential to cause type I allergic reactions in late summer and autumn and represents a major health problem in America and several countries in Europe. Climate change and urbanization, as well as long distance transport capacity, enhance the spread of ragweed pollen. Therefore ragweed is becoming domestic in non-invaded areas which in turn will increase the sensitization rate. So far 11 ragweed allergens have been described and, according to IgE reactivity, Amb a 1 and Amb a 11 seem to be major allergens. Sensitization rates of the other allergens vary between 10 and 50%. Most of the allergens have already been recombinantly produced, but most of them have not been characterized regarding their allergenic activity, therefore no conclusion on the clinical relevance of all the allergens can be made, which is important and necessary for an accurate diagnosis. Pharmacotherapy is the most common treatment for ragweed pollen allergy but fails to impact on the course of allergy. Allergen-specific immunotherapy (AIT) is the only causative and disease-modifying treatment of allergy with long-lasting effects, but currently it is based on the administration of ragweed pollen extract or Amb a 1 only. In order to improve ragweed pollen AIT, new strategies are required with higher efficacy and safety.

scholarly journals Current strategies of allergen-specific immunotherapy

2015 ◽  
Vol 12 (4) ◽  
pp. 16-26
Author(s):  
K S Pavlova ◽  
O M Kurbacheva
Keyword(s):  
Grass Pollen ◽  
Specific Immunotherapy ◽  
Pollen Allergy ◽  
Pollen Extract ◽  
Efficacy And Safety ◽  
Grass Pollen Allergy ◽  
Allergen Specific Immunotherapy ◽  
Natural Exposure ◽  
Safety Studies ◽  
Exposure Conditions

The article discusses the principles of the optimal allergovaccine choice for allergen-specific immunotherapy (ASIT) for grass-pollen-allergy patients; reviewed efficacy and safety studies of the standardized mixt five-grass-pollen extract. Relatively grass sensitization is preferred use mixt grass-pollen extract is thus more suitable for specific immunotherapy, as it contains a broader repertoire of the epitopes, which approximate to the natural exposure conditions.

scholarly journals Implementation and Evaluation of a Communication Strategy to Control Ragweed Pollen

2016 ◽  
Vol 5 (1) ◽  
pp. 87
Author(s):  
Celine Plante ◽  
Audrey Smargiassi ◽  
Francine Hubert ◽  
Sophie Goudreau
Keyword(s):  
Fold Increase ◽  
Ambrosia Artemisiifolia ◽  
Communication Strategy ◽  
Ragweed Pollen ◽  
Communication Intervention ◽  
Effective Measure ◽  
Land Owners ◽  
Before And After ◽  
Logistic Regressions ◽  
The Common

The common ragweed (<em>Ambrosia artemisiifolia</em>) is widespread in southwestern areas of Quebec, Canada. It is known to release large quantities of pollen from July through September, triggering allergic reactions such as rhinitis and generating significant costs for public health. The objective of this study was to implement and evaluate a communication intervention aimed at decreasing ragweed pollen. Selected lands with potential ragweed presence were visited twice, before and after the intervention, on three seasons in the East of the Montreal Island, Quebec. At the first visit done in 2010, 2011, and 2012, ragweed plots were located and measured; at the second visit in 2012, the measures were redone. Various numbers of communications were sent to owners of ragweed-infested lands that included explanations of health impacts of ragweed pollen and the importance of mowing. Mixed logistic regressions were used to test the effect of the number of communications on the mow. In the group that received four notices, a statistically significant three-fold increase in the proportion of land owners that had cut ragweed plots (OR = 3.20; 95 %CI: 1.16-8.84) was noted, compared to the group that received only one notice. For owners of vacant lands, the effect was somewhat more pronounced (OR = 3.82; 95%CI: 1.23-11.67). Nonetheless, the change from one to three communications showed no increase of mowing. In conclusion, the results of the present study suggest that communications and reminders of the importance of ragweed cut to landowners could be an effective measure to limit ragweed pollen.

Isoallergen Analysis of Pectate Lyases (Amb a 1 and Amb a 2) from Commercial Short Ragweed Pollen

2011 ◽  
Vol 127 (2) ◽  
pp. AB168-AB168 ◽  
Author(s):  
A. Nandy ◽  
S. Augustin ◽  
L. Mitulski ◽  
O. Cromwell
Keyword(s):  
Ragweed Pollen ◽  
Pectate Lyases ◽  
Amb A 1

scholarly journals COMPARATIVE CHARACTERISTICS OF SAFETY OF SUBLINGUAL AND PARENTERAL IMMUNOTHERAPY METHODS

2020 ◽  
Vol 17 (34) ◽  
pp. 736-744
Author(s):  
Ulbossyn SALTABAYEVA ◽  
Alexei YUMASHEV
Keyword(s):  
Adverse Reactions ◽  
Specific Immunotherapy ◽  
Sublingual Immunotherapy ◽  
Scientific Evidence ◽  
Adult Population ◽  
Pollen Allergy ◽  
Hay Fever ◽  
Sharp Drop ◽  
Allergen Specific Immunotherapy ◽  
Good Substitute

Among a significant number of allergies, the most common among children and adults is pollen allergy. Pollen allergies primarily lead to irritation of the nose and eyes, but can also cause headaches, weakness, fatigue, and decreased attention span. In an acute allergic reaction, anaphylactic shock can occur, that is, a lifethreatening sharp drop in blood pressure. These and many other consequences of allergic reactions imply the need to create drugs that could cure a person of allergies or stop the manifestation of allergen reactions. The aim of the article was to study the safety of allergen-specific immunotherapy. The research methods included an analysis of the comparison of the effectiveness of two immunotherapy methods, a comparison of the safety of sublingual and parenteral methods of administering allergic vaccines, a comparative assessment of the safety of types of allergen-specific immunotherapy. The study involved 228 patients with varying severity of hay fever, among whom were children from 5 to 18 years old and an adult population (113 patients were men, 115 were women). The study revealed that sublingual immunotherapy increases the safety of treatment and is a good substitute for parenteral immunotherapy, especially in children. The studies have also confirmed well-known scientific evidence on the safety of sublingual immunotherapy in patients with hay fever. It was concluded that sublingual immunotherapy increases the safety of treatment and is a good substitute for the parenteral allergenspecific immunotherapy method, especially in pediatric patients, while having several advantages, such as a significant reduction in adverse reactions, high potency, and a convenient mode of administration, greater patient commitment and trust in treatment, and the elimination of infection transmission.

scholarly journals Frontolimbic brain volume abnormalities in bipolar disorder with suicide attempts

2020 ◽  
Author(s):  
Mbemba Jabbi ◽  
Wade Weber ◽  
Jeffrey Welge ◽  
Fabiano Nery ◽  
Maxwell Tallman ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Suicide Attempts ◽  
The United States ◽  
Anterior Cingulate ◽  
Type I ◽  
Brain Volumes ◽  
Major Health Problem ◽  
Dorsolateral Prefrontal

ABSTRACTOver 2.3 million people in the United States live with bipolar disorder. Sixty percent of those with a bipolar disorder diagnosis attempt suicide at least once in their lifetime, and up to 19% die by suicide. However, the neurobiology of suicide attempts in bipolar disorder remains unclear. Here, we studied the neuroanatomical basis for suicide attempt history in bipolar disorder by measuring gray matter volumes (GMV) to identify differences in brain-volumes in 121 participants with bipolar disorder type I, and healthy participants (n=40). The bipolar group consisted of individuals with suicide attempt history (n=23) and no suicide attempt history (n=58). All participants completed behavioral/diagnostic assessments and MRI measures of GMV. We focused on a predefined frontolimbic circuitry in bipolar disorder versus (vs.) healthy to first identify diagnostic GMV markers and to specifically identify markers for suicide attempt history. We found reduced GMV markers for bipolar diagnosis (i.e., bipolar<healthy) in the anterior cingulate cortex (ACC), and dorsolateral prefrontal cortices (DLPFC). Our observed frontolimbic GMV abnormalities were associated with suicide attempt history and measures of individual variations in current suicidal ideation at the time of scanning. These results identified a frontolimbic-GMV marker for bipolar diagnosis and suicidal behavioral risk tendencies.HighlightsSuicide is a major health problem especially in bipolar disorder but the neurobiological basis for suicide attempts remains obscure. We identified an anterior cingulate and dorsolateral prefrontal cortical volume correlate for suicide attempt history and suicidal ideation and thereby demonstrates a convergent brain marker for suicidal behaviors.

scholarly journals CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION

2021 ◽  
Vol 23 (4) ◽  
pp. 921-926
Author(s):  
N. N. Zhukova ◽  
M. V. Manzhos ◽  
L. R. Khabibulina ◽  
E. Yu. Syrtsova
Keyword(s):  
Allergic Rhinitis ◽  
Russian Federation ◽  
Allergic Diseases ◽  
Ambrosia Artemisiifolia ◽  
Control Group ◽  
Ambrosia Trifida ◽  
Results Of Treatment ◽  
Amb A 1 ◽  
The Russian Federation ◽  
Time Changes

Allergic rhinitis and bronchial asthma are widespread respiratory allergic diseases. In some territories of the Russian Federation, the dominant cause of pollinosis is ragweed. The aim of the study was to evaluate the clinical and immunological efficacy of ASIT with the allergen Ambrosia artemisiifolia in patients sensitized to Ambrosia trifida in the Samara region. Patients with proven sensitization to Ambrosia trifida was held immunotherapy with Ambrosia artemisiifolia allergoid preseason. After treatment, patients had a decrease in the severity of symptoms of allergic rhinitis according to VAS (p = 0.00001), a decrease in the need for medications (p = 0.0003), as well as the need for corticosteroids against the background of therapy from 34.6% to 0% (p = 0.00001). In 8% of cases, the result of treatment was good, in 69% satisfactory, in 23% unsatisfactory. In the control group, there were no changes in the severity of symptoms (p = 0.858). Also, in the control group, the need for medications remained unchanged and 14.3% of patients continued to use corticosteroids.After ASIT, there was a decrease in the level of IL-4 (p = 0.002), and a decrease in the ratio of IL-4/ IL-10 (p = 0.0063); at the same time, changes in the level of other cytokines (IL-10; IFNγ) were statistically insignificant (p > 0.05). Before treatment, the levels of IL-4/ IL-10 in both groups were comparable, and after treatment, the differences became statistically significant (p = 0.031). We did not get a statistically significant change in the level of IgG4 Amb a 1 or IgG4 Amb trifida. There was no correlation between the level of individual cytokines and the results of treatment. As a result of the conducted ASIT, positive clinical and immunological results were obtained. In most patients, the disease has acquired a controlled course. At the same time, the lack of excellent and low number of good results of ASIT is probably due to the intraspecific allergenic properties of ragweed. 

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