scholarly journals A review of clinical efficacy, safety, new developments and adherence to allergen-specific immunotherapy in patients with allergic rhinitis caused by allergy to ragweed pollen (Ambrosia artemisiifolia)

2017 ◽  
Vol Volume 11 ◽  
pp. 247-257 ◽  
Author(s):  
Mirjana Turkalj ◽  
Ivana Banic ◽  
Srdjan Ante Anzic
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Efficacy ◽  
Specific Immunotherapy ◽  
Ambrosia Artemisiifolia ◽  
Ragweed Pollen ◽  
Allergen Specific Immunotherapy ◽  
New Developments

scholarly journals Current issues on sublingual allergen-specific immunotherapy in children with asthma and allergic rhinitis

2016 ◽  
Vol 144 (5-6) ◽  
pp. 345-350 ◽  
Author(s):  
Zorica Zivkovic ◽  
Ivana Djuric-Filipovic ◽  
Snezana Zivanovic
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Efficacy ◽  
Randomized Clinical Trials ◽  
Specific Immunotherapy ◽  
Meta Analysis ◽  
Immune Therapy ◽  
Real Life ◽  
World Health ◽  
Sublingual Administration ◽  
Allergen Specific Immunotherapy

In 1993 the European Academy of Allergy and Clinical Immunology was the first official organization to recognize that sublingual administration could be ?promising route? for allergic desensitization. A few years later, the World Health Organization recommended this therapy as ?a viable alternative to the injection route in adults.? The first meta-analysis showed sublingual allergen specific immunotherapy (SLIT) effectiveness for allergic rhinitis and another study showed SLIT can actually help prevent the development of asthma both in adults and in children. The main goal of this review article is to present insight into the most up-to-date understanding of the clinical efficacy and safety of immunotherapy in the treatment of pediatric patients with allergic rhinitis and asthma. A literature review was performed on PubMed from 1990 to 2015 using the terms ?asthma,? ?allergic rhinitis,? ?children,? ?allergen specific immune therapy.? Evaluating data from double-blind placebo-controlled randomized clinical trials (DB-PC-RCTs), the clinical efficacy (assessed as the reduction of symptom score and the need of rescue medicament) of SLIT for allergic rhinitis and allergic asthma, has been confirmed in various meta-analysis Outcomes such as rhinoconjunctivitis score and medication scores, combined scores, quality of life, days with severe symptoms, immunological endpoints, and safety parameters were all improved in the SLIT-tablet compared with placebo group. SLIT safety has been already proven in many DB-PC-RCTs and real-life settings. In accordance with all of the above mentioned, the goals for future trials and studies are the development of comprehensive guidelines for clinical practice on immunotherapy, embracing all the different potential participants. The importance of allergen immunotherapy is of special relevance in the pediatric age, when the plasticity and modulability of the immune system are maximal, and when preventative effects can be reasonably expected.

Effects of allergen-specific immunotherapy on functions of helper and regulatory T cells in patients with seasonal allergic rhinitis

2011 ◽  
Vol 22 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Cengiz Kirmaz ◽  
Ozlem Ozenturk Kirgiz ◽  
Papatya Bayrak ◽  
Ozge Yilmaz ◽  
Seda Vatansever ◽  
...  
Keyword(s):  
T Cells ◽  
Allergic Rhinitis ◽  
Regulatory T Cells ◽  
Seasonal Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
Allergen Specific Immunotherapy

Long-term effects of allergen-specific subcutaneous immunotherapy for house dust mite induced allergic rhinitis

2017 ◽  
Vol 131 (11) ◽  
pp. 997-1001 ◽  
Author(s):  
E Sahin ◽  
D Dizdar ◽  
M E Dinc ◽  
A A Cirik
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Specific Immunotherapy ◽  
Subcutaneous Immunotherapy ◽  
Long Term Effects ◽  
Allergen Specific Immunotherapy ◽  
Dust Mite ◽  
Symptom Scores

AbstractBackground:Allergic rhinitis is strongly associated with the presence of house dust mites. This study investigated the long-term effects of allergen-specific immunotherapy. Allergen-specific immunotherapy was applied over three years. The study was based on a 10-year follow up of patients with allergic rhinitis.Methods:The study was conducted between 2001 and 2015. Skin prick test results and symptom scores were evaluated before (26 patients) and after 3 years (20 patients) of allergen-specific immunotherapy (using data from a previously published study), and 10 years after allergen-specific immunotherapy had ended (20 of 26 patients).Results:The symptom scores before allergen-specific immunotherapy were significantly higher than those obtained after 3 years of allergen-specific immunotherapy and 10 years after allergen-specific immunotherapy (p < 0.0175). There were no significant differences between the scores obtained at 3 years and 10 years after allergen-specific immunotherapy (p > 0.0175).Conclusion:Subcutaneous immunotherapy is an effective treatment for house dust mite induced allergic rhinitis.

GA2LEN/EAACI pocket guide for allergen-specific immunotherapy for allergic rhinitis and asthma

Allergy ◽  
2010 ◽  
Vol 65 (12) ◽  
pp. 1525-1530 ◽  
Author(s):  
T. Zuberbier ◽  
C. Bachert ◽  
P. J. Bousquet ◽  
G. Passalacqua ◽  
G. Walter Canonica ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
Allergen Specific Immunotherapy
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