Modification of the Pulmonary Connective Tissue Developmental Response in the Neonatal Rat by Ciclosporin

1991 ◽  
Vol 16 (2) ◽  
pp. 89-98 ◽  
Author(s):  
Philip J. Roos ◽  
Coenraad M. van Gent ◽  
James C. Mauch ◽  
James W. Blankenship ◽  
Leonard L. Bailey ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Neonatal Rat ◽  
Pulmonary Connective Tissue

CELLULAR AND SUBCELLULAR LOCALIZATION OF 3H-OESTRADIOL IN THE OVIDUCT AND UTERUS OF THE NEONATAL RAT

1974 ◽  
Vol 76 (3) ◽  
pp. 570-575 ◽  
Author(s):  
Peter J. Sheridan ◽  
Madhabananda Sar ◽  
Walter E. Stumpf
Keyword(s):  
Body Weight ◽  
Connective Tissue ◽  
Subcellular Localization ◽  
Neonatal Rat ◽  
Female Rats ◽  
Methyl Green ◽  
Luminal Epithelium ◽  
Frozen Sections

ABSTRACT Two day old female rats were injected sc with 1.0 μg of 3H-oestradiol per 100 g body weight and killed 2 h later. Oviducts and uteri were removed, mounted on tissue holders, and frozen in liquefied propane. Four μm frozen sections were cut in a cryostat and mounted according to the dry-mount and thaw-mount autoradiographic procedures. The sections were exposed at –15°C for different periods of time, then photographically processed and stained with methyl green-pyronin. Radioactivity was found concentrated in nuclei of cells of the luminal epithelium in the uterus, but not in the oviduct, while cells of the connective tissue and muscularis showed nuclear concentration of radioactivity in both organs. Pretreatment with oestradiol inhibited the nuclear concentration of radioactivity, whereas pretreatment with 5α-dihydrotestosterone had no effect. It is concluded that both the uterus and oviduct of the neonatal rat have receptors for oestrogen as early as 2 days after birth.

Electron microscopic observations on pulmonary connective tissue stained by Ruthenium Red

1982 ◽  
Vol 14 (2) ◽  
pp. 257-271 ◽  
Author(s):  
Kimihiko Takusagawa ◽  
Fumio Ariji ◽  
Kuniji Shida ◽  
Toshio Sato ◽  
Noboru Asoo ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Ruthenium Red ◽  
Electron Microscopic ◽  
Pulmonary Connective Tissue

scholarly journals Rare Pulmonary Connective Tissue Type Mast Cells Regulate Lung Endothelial Cell Angiogenesis

2020 ◽  
Vol 190 (8) ◽  
pp. 1763-1773
Author(s):  
Yue Ren ◽  
Yuyan Lyu ◽  
Jared A. Mereness ◽  
Shumin Wang ◽  
Jinjiang Pang ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Mast Cells ◽  
Connective Tissue ◽  
Tissue Type ◽  
Pulmonary Connective Tissue

scholarly journals Morphological features of histogenic differon cells in connective tissue of guinea pigs’ lungs after sensitization with ovalbumin

2021 ◽  
Vol 14 (2) ◽  
pp. 220-225
Author(s):  
S. S. Popko ◽  
V. M. Yevtushenko
Keyword(s):  
Connective Tissue ◽  
Guinea Pigs ◽  
Morphological Changes ◽  
Early Period ◽  
Allergic Inflammation ◽  
Morphological Features ◽  
Control Group ◽  
Group A ◽  
Experimental Sensitization ◽  
Pulmonary Connective Tissue

An urgent issue of modern morphology is establishing a number of patterns of morphological changes and reactivity of connective tissue components of lungs in case of experimental sensitization with allergens. The aim is to estimate morphological features of histogenic differon cells in connective tissue of guinea pigs’ lungs after sensitization with ovalbumin. Materials and methods. Using morphometric and histological method, we have estimated the lung connective tissue of 48 male guinea pigs with experimental ovalbumin-induced allergic inflammation, simulated by subcutaneous sensitization and aeroallergization with ovalbumin. The number of fibrocytes, fibroblasts per 5000 μm2 and their ratio – fibroblast/fibrocyte coefficient were determined. Results. We have established the regularity of morphological changes dynamics in the cellular elements of pulmonary connective tissue. Experimental sensitization and inhalated allergization with ovalbumin leads to a statistically significant increase in the average number of fibroblasts and fibrocytes throughout the observation period in all experimental groups. It has been proved that the dynamics of cells has a multidirectional character, demonstrated by indicators of the fibroblast/fibrocyte coefficient, which shows the disproportion in the fibroblast/fibrocyte ratio and proves the tendency to the development of fibrosis in guinea pigs’ pulmonary connective tissue in case of experimental sensitization with ovalbumin. Conclusions. A gradual increase in the number of fibrocytes, against the background of a decrease in the number of fibroblasts is observed from the 23rd day to the completion of experimental sensitization with ovalbumin in the lungs of guinea pigs, compared with control group. A decrease of fibroblast/fibrocyte coefficient from 1.37 ± 0.03 in the early period to 0.82 ± 0.03 in the late period of the allergic inflammation demonstrates multidirectional nature of the dynamics in the number of connective tissue cells and indicates a tendency towards the development of fibrosis in pulmonary connective tissue.

Pulmonary Connective Tissue and Environmental Lung Disease

CHEST Journal ◽  
1981 ◽  
Vol 80 (1) ◽  
pp. 33S-38S ◽  
Author(s):  
Ronald G. Crystal ◽  
Stephen I. Rennard
Keyword(s):  
Connective Tissue ◽  
Lung Disease ◽  
Pulmonary Connective Tissue
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