scholarly journals Rare Pulmonary Connective Tissue Type Mast Cells Regulate Lung Endothelial Cell Angiogenesis

2020 ◽  
Vol 190 (8) ◽  
pp. 1763-1773
Author(s):  
Yue Ren ◽  
Yuyan Lyu ◽  
Jared A. Mereness ◽  
Shumin Wang ◽  
Jinjiang Pang ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Mast Cells ◽  
Connective Tissue ◽  
Tissue Type ◽  
Pulmonary Connective Tissue

Extensive proliferation of mature connective-tissue type mast cells in vitro

Nature ◽  
1986 ◽  
Vol 324 (6092) ◽  
pp. 65-67 ◽  
Author(s):  
Tatsutoshi Nakahata ◽  
Toshimi Kobayashi ◽  
Akira Ishiguro ◽  
Kohichiro Tsuji ◽  
Kuniaki Naganuma ◽  
...  
Keyword(s):  
Mast Cells ◽  
Connective Tissue ◽  
Tissue Type

Mutual Phenotypic Changes between Connective Tissue Type and Mucosal Mast Cells

1987 ◽  
Vol 82 (3-4) ◽  
pp. 244-248 ◽  
Author(s):  
Yukihiko Kitamura ◽  
Yuzuru Kanakura ◽  
Sanae Sonoda ◽  
Hidekazu Asai ◽  
Toru Nakano
Keyword(s):  
Mast Cells ◽  
Connective Tissue ◽  
Tissue Type ◽  
Phenotypic Changes ◽  
Mucosal Mast Cells

scholarly journals Cell Intrinsic Deregulated ß-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer

2019 ◽  
Vol 10 ◽  
Author(s):  
Abdulrahman Saadalla ◽  
Mariana Machado Lima ◽  
Funien Tsai ◽  
Abu Osman ◽  
Mahendra Pal Singh ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Colon Cancer ◽  
Mast Cells ◽  
Connective Tissue ◽  
Systemic Inflammation ◽  
Tissue Type

scholarly journals Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Elín I. Magnúsdóttir ◽  
Mirjana Grujic ◽  
Jessica Bergman ◽  
Gunnar Pejler ◽  
Malin C. Lagerström
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Connective Tissue ◽  
Treatment Options ◽  
Cell Types ◽  
Tissue Type ◽  
Human Mast Cell ◽  
Knock Out ◽  
Endothelin 1 ◽  
Deficient Mice

Abstract Background Itch is an unpleasant sensation that can be debilitating, especially if it is chronic and of non-histaminergic origin, as treatment options are limited. Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that also has the ability to induce a burning, non-histaminergic pruritus when exogenously administered, by activating the endothelin A receptor (ETAR) on primary afferents. ET-1 is released endogenously by several cell-types found in the skin, including macrophages and keratinocytes. Mast cells express ETARs and can thereby be degranulated by ET-1, and mast cell proteases chymase and carboxypeptidase A3 (CPA3) are known to either generate or degrade ET-1, respectively, suggesting a role for mast cell proteases in the regulation of ET-1-induced itch. The mouse mast cell proteases (mMCPs) mMCP4 (chymase), mMCP6 (tryptase), and CPA3 are found in connective tissue type mast cells and are the closest functional homologs to human mast cell proteases, but little is known about their role in endothelin-induced itch. Methods In this study, we evaluated the effects of mast cell protease deficiency on scratching behavior induced by ET-1. To investigate this, mMCP knock-out and transgenic mice were injected intradermally with ET-1 and their scratching behavior was recorded and analyzed. Results CPA3-deficient mice and mice lacking all three proteases demonstrated highly elevated levels of scratching behavior compared with wild-type controls. A modest increase in the number of scratching bouts was also seen in mMCP6-deficient mice, while mMCP4-deficiency did not have any effect. Conclusion Altogether, these findings identify a prominent role for the mast cell proteases, in particular CPA3, in the protection against itch induced by ET-1.

scholarly journals Effects of interleukin-3 and interleukin-4 on the development of "connective tissue-type" mast cells: interleukin-3 supports their survival and interleukin-4 triggers and supports their proliferation synergistically with interleukin-3

Blood ◽  
1990 ◽  
Vol 75 (2) ◽  
pp. 421-427 ◽  
Author(s):  
K Tsuji ◽  
T Nakahata ◽  
M Takagi ◽  
T Kobayashi ◽  
A Ishiguro ◽  
...  
Keyword(s):  
Mast Cells ◽  
Connective Tissue ◽  
Colony Formation ◽  
Colony Growth ◽  
Interleukin 4 ◽  
Tissue Type ◽  
Dependent Manner ◽  
Humoral Factors ◽  
Interleukin 3

Abstract We examined the effects of interleukin-3 (IL-3) and interleukin-4 (IL- 4) on connective tissue-type mast cells (CTMC) purified from murine peritoneal cells. Although both factors failed to induce extensive proliferation of CTMC, they stimulated CTMC proliferation synergistically in a dose-dependent manner. Pretreatment of CTMC with IL-3 and/or IL-4 indicated that the sustained presence of both factors was required for the development of type 1 mast cell colonies. The delayed addition of IL-3 to cultures of purified CTMC with IL-4 induced no colony formation, while the delayed addition of IL-4 to cultures with IL-3, even on day 28 of culture, induced type 1 colony formation. In replating type 1 colonies induced by IL-3 and IL-4 to secondary cultures with IL-3 alone, few secondary colonies developed. However, the delayed addition of IL-4 to the secondary culture induced many type 1 colonies. The purified CTMC cultured with IL-3 retained the morphological and cytochemical characteristics of CTMC, as well as proliferative ability. These observations indicate that IL-3 supports the survival of CTMC in methylcellulose culture and that IL-4 triggers and supports CTMC proliferation synergistically with IL-3. The serum- free culture of purified CTMC and the culture of single CTMC demonstrated that the synergistic effect of IL-3 and IL-4 on colony growth and the surviving effect of IL-3 on CTMC require no influence from accessory cells or other humoral factors.

scholarly journals Author Correction: Novel six-week protocol for generating functional human connective tissue-type (MCTC) mast cells from buffy coats

2017 ◽  
Vol 67 (1) ◽  
pp. 105-105
Author(s):  
Issan Yee San Tam ◽  
Chun Wai Ng ◽  
See-Ying Tam ◽  
Hang Yung Alaster Lau
Keyword(s):  
Mast Cells ◽  
Connective Tissue ◽  
Tissue Type ◽  
Generating Functional

Involvement of connective tissue–type mast cells in Th1 immune responses via Stat4 expression

Blood ◽  
2005 ◽  
Vol 105 (3) ◽  
pp. 1016-1020 ◽  
Author(s):  
Tatsuki R. Kataoka ◽  
Nobuyasu Komazawa ◽  
Eiichi Morii ◽  
Keisuke Oboki ◽  
Toru Nakano
Keyword(s):  
Mast Cells ◽  
Connective Tissue ◽  
Immune Responses ◽  
Tissue Type ◽  
Hematopoietic Stem ◽  
Α Subunit ◽  
Enhanced Expression ◽  
Microphthalmia Transcription Factor ◽  
Nitric Oxide Synthase 2 ◽  
Th1 Immune Responses

Abstract Mast cells are the sentinels of immune systems and, like other immuno-competent cells, they are produced by hematopoietic stem cells. We analyzed the expression of signal transducer and activator of transcription 4 (Stat4), and investigated its role in mast cells. Murine mast cells are usually divided into 2 distinct populations by their distribution and contents of their granules: mucosal mast cells (MMCs) and connective tissue–type mast cells (CTMCs). Stat4 protein was detected in CTMCs but not in MMCs. The absence of Stat4 expression in cultured mast cells was due to the presence of Stat6. In T-helper (Th) cells, Stat4 plays an important role in Th1 shift by inducing a set of genes, such as interferon gamma (IFN-γ) and interleukin-18 receptor α subunit (IL-18Rα). As in Th1 shift, we found that Stat4 trans-activated these genes in the Stat4-expressing cultured mast cells, namely, microphthalmia transcription factor (MITF)–deficient cultured MMCs, Stat6-deficient cultured MMCs, and cultured CTMCs. Stat4 also enhanced expression of nitric oxide synthase 2 (NOS2) in CTMCs, which brought about increased levels of NO-dependent cytotoxic activity. These data indicate that expression of Stat4 in CTMCs plays an important role on Th1 immune responses.

Sign in / Sign up

Export Citation Format

Share Document