Effects of 3 Months' Neoadjuvant Hormonal Treatment with a GnRH Analogue (Triptorelin) prior to Radical Retropubic Prostatectomy on Prostate-Specific Antigen and Tumour Volume in Prostate Cancer

1994 ◽  
Vol 26 (1) ◽  
pp. 22-28 ◽  
Author(s):  
G. Aus ◽  
S. Brändstedt ◽  
M. Häggman ◽  
K. Pedersen ◽  
M. de la Torre ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Hormonal Treatment ◽  
Tumour Volume ◽  
Radical Retropubic Prostatectomy ◽  
Gnrh Analogue ◽  
Retropubic Prostatectomy

scholarly journals Stage T2 prostate cancer presented with high serum prostate specific antigen and nonspecific bone lesions

2007 ◽  
Vol 54 (4) ◽  
pp. 109-112 ◽  
Author(s):  
T. Pejcic ◽  
J. Hadzi-Djokic ◽  
B.B. Markovic ◽  
H.M. Maksimovic ◽  
M. Acimovic ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
High Serum ◽  
Radical Retropubic Prostatectomy ◽  
Bone Lesions ◽  
Gleason Grade ◽  
Retropubic Prostatectomy ◽  
Pathological Conditions ◽  
Tissue Production

Objective: To present the case of T2 prostate cancer (PCa) mimicking disseminated PCa that was successfully treated with radical retropubic prostatectomy (RRP). Patient and the method: The patient had prostate specific antigen (PSA) level higher than 30ng/ml and multiple atypical lesions on bone scan. TRUS guided biopsy proved small PCa, only in 1/18 biopsy cores, with Gleason grade 6 (3+3). Bone lesions appeared to be posttraumatic. Result: The patient underwent RRP; six months after surgery there is no evidence of the disease. Conclusion: Serum PSA level is the sum of cancer activity, normal and BHP tissue production, as well as the result of other pathological conditions, like prostatitis. In some cases, inflammation can be responsible for high PSA level and over-staging.

scholarly journals Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes

2021 ◽  
Vol 10 (22) ◽  
pp. 5307
Author(s):  
Alicja Popiołek ◽  
Bartosz Brzoszczyk ◽  
Piotr Jarzemski ◽  
Aleksandra Chyrek-Tomaszewska ◽  
Radosław Wieczór ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Prostate Specific Antigen ◽  
Verbal Memory ◽  
Demographic Data ◽  
Specific Antigen ◽  
Hormonal Treatment ◽  
Cognitive Test ◽  
Prostate Cancer Survivors

Prostate cancer (PC) is one of the most common malignancies in men. The increase in the number of PC survivors is associated with many problems including cognitive impairment. Early detection of such problems facilitates timely protective intervention. This study examined the association between prostate-specific antigen (PSA) or testosterone (T) levels and cognitive function in patients undergoing radical prostatectomy. Such a correlation could help identify patient groups at risk of cognitive impairment. Participants underwent clinical (demographic data, medical history, physical examination, and blood analyses) and neuropsychological assessment (cognitive test battery). Preoperative PSA or T levels were not associated with cognitive function. However, long-term follow-up after prostatectomy showed a strong correlation between PSA levels and the results of verbal memory and executive function tests. A trend toward significance was also observed for visuospatial memory. The levels of free T and total T were not correlated with cognitive function. Only the levels of free T after hormonal treatment were significantly correlated with executive functions. Comorbid diabetes affected these correlations. In conclusion, PSA levels at a distant postoperative time and free T level after hormonal treatment may be biomarkers of cognitive function.

Prostate-specific antigen failure despite pathologically organ-confined and margin-negative prostate cancer: the basis for an adjuvant therapy trial.

1997 ◽  
Vol 15 (4) ◽  
pp. 1465-1469 ◽  
Author(s):  
A V D'Amico ◽  
R Whittington ◽  
S B Malkowicz ◽  
D Schultz ◽  
J E Tomaszewski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Adjuvant Therapy ◽  
Cancer Patients ◽  
Prostate Specific Antigen ◽  
Gleason Score ◽  
Multivariable Analysis ◽  
Specific Antigen ◽  
Radical Retropubic Prostatectomy ◽  
Phase Iii ◽  
Psa Failure

PURPOSE A multivariable analysis to evaluate the potential clinical and pathologic factors that predict for early biochemical failure in patients with pathologically organ-confined and margin-negative disease was performed to define patients who may benefit from adjuvant therapy. PATIENTS AND METHODS Three hundred forty-one prostate cancer patients treated with a radical retropubic prostatectomy between January 1989 and June 1995 and found to have pathologically organ-confined and margin-negative disease comprised the study population. A logistic regression multivariable analysis to evaluate the predictive value of the preoperative prostate-specific antigen (PSA) level, pathologic (prostatectomy) Gleason score, and pathologic stage on PSA failure occurring during the first postoperative year was performed. RESULTS Predictors of PSA failure during the first postoperative year in patients with pathologically organ-confined disease included pathologic Gleason score > or = 7 (P = .0007) and preoperative PSA level greater than 10 (P < .0001). Corresponding 3-year freedom-from-PSA-failure rates for these pathologic organ-confined patients with both, one, or neither of these factors were 60%, 75% to 84%, and 95%, respectively (P < .0001). CONCLUSION Prostate cancer patients with pathologically organ-confined and margin-negative disease and a preoperative PSA level greater than 10 ng/mL or a pathologic Gleason score > or = 7 have significant decrements in short-term PSA-failure-free survival. Therefore, these patients should be considered for adjuvant therapy in the setting of a phase III clinical trial.

CHARACTERIZATION AND PREDICTORS OF PROSTATE SPECIFIC ANTIGEN PROGRESSION RATES AFTER RADICAL RETROPUBIC PROSTATECTOMY

2000 ◽  
Vol 164 (3 Part 1) ◽  
pp. 749-753 ◽  
Author(s):  
MICHAEL O. KOCH ◽  
RICHARD S. FOSTER ◽  
BRADLEY BELL ◽  
STEPHEN BECK ◽  
LIANG CHENG ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Radical Retropubic Prostatectomy ◽  
Retropubic Prostatectomy
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