scholarly journals Stage T2 prostate cancer presented with high serum prostate specific antigen and nonspecific bone lesions

2007 ◽  
Vol 54 (4) ◽  
pp. 109-112 ◽  
Author(s):  
T. Pejcic ◽  
J. Hadzi-Djokic ◽  
B.B. Markovic ◽  
H.M. Maksimovic ◽  
M. Acimovic ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
High Serum ◽  
Radical Retropubic Prostatectomy ◽  
Bone Lesions ◽  
Gleason Grade ◽  
Retropubic Prostatectomy ◽  
Pathological Conditions ◽  
Tissue Production

Objective: To present the case of T2 prostate cancer (PCa) mimicking disseminated PCa that was successfully treated with radical retropubic prostatectomy (RRP). Patient and the method: The patient had prostate specific antigen (PSA) level higher than 30ng/ml and multiple atypical lesions on bone scan. TRUS guided biopsy proved small PCa, only in 1/18 biopsy cores, with Gleason grade 6 (3+3). Bone lesions appeared to be posttraumatic. Result: The patient underwent RRP; six months after surgery there is no evidence of the disease. Conclusion: Serum PSA level is the sum of cancer activity, normal and BHP tissue production, as well as the result of other pathological conditions, like prostatitis. In some cases, inflammation can be responsible for high PSA level and over-staging.

scholarly journals Significance of the correlation between serum-prostate specific antigen and the percentage of prostate cancer volume in postoperative biochemical progression

2017 ◽  
Vol 145 (11-12) ◽  
pp. 599-604
Author(s):  
Aleksandar Spasic ◽  
Snezana Cerovic ◽  
Dejan Simic ◽  
Mirko Jovanovic ◽  
Ivica Nikolic ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Visual Assessment ◽  
Radical Retropubic Prostatectomy ◽  
Gleason Grade ◽  
Results Of Treatment ◽  
Percentage Volume ◽  
Biochemical Progression ◽  
Biopsy Gleason Score

Introduction/Objective. Radical prostatectomy (RP) is the best form of treatment of patients with locally confined prostate cancer (PC). Biochemical progression (BP) of the disease occurs in 27?53% of patients after RP. The aim of our analysis was to assess the significance of the correlation of preoperative prostate-specific antigen (PSA) values and the percentage volume of PC in biochemical progression in patients with RP and the biopsy Gleason score of 6 and 7. Methods. The analysis included the results of treatment of 228 patients with the committed radical retropubic prostatectomy for localized PC in the 2007?2011 period. According to the Gleason grade system values, three groups were identified ? 6 (3 + 3), 7 (3 + 4) and 7 (4 + 3). According to the preoperative PSA values the following three groups were determined and monitored: ? 4 ng/ml, 4.1?10 ng/ml, and ? 10.1 ng/ml. Biochemical progression was defined as two consecutive increases of PSA values ? 0.2 ng/ml after RP. The percentage of tumor volume (PTV) is determined by a visual assessment of the percentage of PC in each microscopic sample. Four PTV groups were determined: 0?5%, 6?25%, 26?50%, and 51?100%. Results. Biochemical progression was registered in 19 patients. Most frequent PTV in the group of patients with BP and from biopsy and RP was 6?50%, an average of 30%. Conclusion. Our study showed predictive significant connections between preoperative PSA values and the values of PTV after operational treatment and that these are independent parameters in the assessment of treatment results.

Prostate-specific antigen failure despite pathologically organ-confined and margin-negative prostate cancer: the basis for an adjuvant therapy trial.

1997 ◽  
Vol 15 (4) ◽  
pp. 1465-1469 ◽  
Author(s):  
A V D'Amico ◽  
R Whittington ◽  
S B Malkowicz ◽  
D Schultz ◽  
J E Tomaszewski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Adjuvant Therapy ◽  
Cancer Patients ◽  
Prostate Specific Antigen ◽  
Gleason Score ◽  
Multivariable Analysis ◽  
Specific Antigen ◽  
Radical Retropubic Prostatectomy ◽  
Phase Iii ◽  
Psa Failure

PURPOSE A multivariable analysis to evaluate the potential clinical and pathologic factors that predict for early biochemical failure in patients with pathologically organ-confined and margin-negative disease was performed to define patients who may benefit from adjuvant therapy. PATIENTS AND METHODS Three hundred forty-one prostate cancer patients treated with a radical retropubic prostatectomy between January 1989 and June 1995 and found to have pathologically organ-confined and margin-negative disease comprised the study population. A logistic regression multivariable analysis to evaluate the predictive value of the preoperative prostate-specific antigen (PSA) level, pathologic (prostatectomy) Gleason score, and pathologic stage on PSA failure occurring during the first postoperative year was performed. RESULTS Predictors of PSA failure during the first postoperative year in patients with pathologically organ-confined disease included pathologic Gleason score > or = 7 (P = .0007) and preoperative PSA level greater than 10 (P < .0001). Corresponding 3-year freedom-from-PSA-failure rates for these pathologic organ-confined patients with both, one, or neither of these factors were 60%, 75% to 84%, and 95%, respectively (P < .0001). CONCLUSION Prostate cancer patients with pathologically organ-confined and margin-negative disease and a preoperative PSA level greater than 10 ng/mL or a pathologic Gleason score > or = 7 have significant decrements in short-term PSA-failure-free survival. Therefore, these patients should be considered for adjuvant therapy in the setting of a phase III clinical trial.

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