Prostate-Specific Antigen Levels after Radical Prostatectomy and Immediate Adjuvant Hormonal Treatment for Stage D1 Prostate Cancer Are Predictive of Early Disease Outcome

1994 ◽  
Vol 25 (3) ◽  
pp. 189-193 ◽  
Author(s):  
Wai S. Cheng ◽  
Erik J. Bergstralh ◽  
Mark Frydenberg ◽  
Horst Zincke
2006 ◽  
Vol 176 (2) ◽  
pp. 559-563 ◽  
Author(s):  
Shomik Sengupta ◽  
Carl M. Christensen ◽  
Horst Zincke ◽  
Jeffrey M. Slezak ◽  
Bradley C. Leibovich ◽  
...  

2015 ◽  
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pp. 16.e1-16.e7 ◽  
Author(s):  
Heikki Seikkula ◽  
Kari T. Syvänen ◽  
Samu Kurki ◽  
Tuomas Mirtti ◽  
Pekka Taimen ◽  
...  

1993 ◽  
Vol 149 (4) ◽  
pp. 787-792 ◽  
Author(s):  
Thomas A. Stamey ◽  
Howard C.B. Graves ◽  
Nancy Wehner ◽  
Michelle Ferrari ◽  
Fuad S. Freiha

2021 ◽  
Vol 10 (22) ◽  
pp. 5307
Author(s):  
Alicja Popiołek ◽  
Bartosz Brzoszczyk ◽  
Piotr Jarzemski ◽  
Aleksandra Chyrek-Tomaszewska ◽  
Radosław Wieczór ◽  
...  

Prostate cancer (PC) is one of the most common malignancies in men. The increase in the number of PC survivors is associated with many problems including cognitive impairment. Early detection of such problems facilitates timely protective intervention. This study examined the association between prostate-specific antigen (PSA) or testosterone (T) levels and cognitive function in patients undergoing radical prostatectomy. Such a correlation could help identify patient groups at risk of cognitive impairment. Participants underwent clinical (demographic data, medical history, physical examination, and blood analyses) and neuropsychological assessment (cognitive test battery). Preoperative PSA or T levels were not associated with cognitive function. However, long-term follow-up after prostatectomy showed a strong correlation between PSA levels and the results of verbal memory and executive function tests. A trend toward significance was also observed for visuospatial memory. The levels of free T and total T were not correlated with cognitive function. Only the levels of free T after hormonal treatment were significantly correlated with executive functions. Comorbid diabetes affected these correlations. In conclusion, PSA levels at a distant postoperative time and free T level after hormonal treatment may be biomarkers of cognitive function.


Urology ◽  
2007 ◽  
Vol 70 (6) ◽  
pp. 1141-1145 ◽  
Author(s):  
Vladimir Mouraviev ◽  
Leon Sun ◽  
John F. Madden ◽  
Janice M. Mayes ◽  
Judd W. Moul ◽  
...  

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