ABCB1 and SLCO1B3 Gene Polymorphisms and Their Impact on Digoxin Pharmacokinetics in Atrial Fibrillation Patients among the Tunisian Population

Pharmacology ◽  
2017 ◽  
Vol 99 (5-6) ◽  
pp. 250-258 ◽  
Author(s):  
Nejia Tounsi ◽  
Imen Trabelsi ◽  
Emna Kerkeni ◽  
Mohamed Habib Grissa ◽  
Nizar Fredj ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Gene Polymorphisms ◽  
Tunisian Population ◽  
Digoxin Pharmacokinetics

Contribution of the ACE (rs1799752) and CYP11B2 (rs1799998) Gene Polymorphisms to Atrial Fibrillation in the Tunisian Population

2021 ◽  
pp. 109980042110293
Author(s):  
Ilhem Gouissem ◽  
Fatma Midani ◽  
Hayet Soualmia ◽  
Meryem Bouchemi ◽  
Sana Ouali ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Gene Polymorphisms ◽  
Tunisian Population ◽  
Genotype Distribution ◽  
Confounding Factors ◽  
Pcr Rflp ◽  
Study Population ◽  
Polymerase Chain ◽  
And Control ◽  
T Haplotype

Background: This study investigated the association of angiotensin–converting enzyme (ACE I/D) and aldosterone synthase (CYP11B2-344C/T) gene polymorphisms in the renin–angiotensin–aldosterone system (RAAS) with atrial fibrillation (AF) in the Tunisian population. Materials and Methods: The study population included 120 patients with AF and 123 age-matched controls. Genotyping of the I/D polymorphism in the ACE gene and the -344C/T polymorphism in the CYP11B2 gene was performed by polymerase chain reaction (PCR) and PCR-RFLP methods, respectively. Results: The genotype distribution of the ACE I/D and CYP11B2-344C/T polymorphisms was significantly different between AF patients and control participants ( p < 0.01 and p < 0.006 respectively). In addition, ACE I/D increased the risk of AF significantly by 3.41-fold for the DD genotype (OR = 3.41; 95% CI [1.39–8.34]; p < 0.007), and after adjusting for confounding factors (age, diabetes, hypertension, and dyslipidemia), the risk was higher (OR = 5.71; 95% CI [1.48–21.98]; p < 0.01). Likewise, the CYP11B2-344C/T polymorphism increased the incidence of AF for the TT genotype (OR = 3.66; 95% CI [1.62–8.27]; p < 0.002) and the CT genotype (OR = 2.68; 95% CI [1.22–5.86]; p < 0.01). After adjusting for confounding factors (age, diabetes, hypertension and dyslipidemia), the risk remained higher for the TT genotype (OR = 3.58; 95% CI [1.08–11.77]; p < 0.03). Furthermore, the haplotype–based association of the ACE I/D and CYP11B2-344C/T polymorphisms showed that the D-T haplotype increased the risk for AF. Conclusion: Our study suggests a significant association of the ACE (I/D) and CYP11B2-344C/T polymorphisms with AF in the Tunisian population.

scholarly journals Predictive factors of cognitive impairment in Tunisian population with non valvular atrial fibrillation

2019 ◽  
Vol 11 (1) ◽  
pp. e295-e296
Author(s):  
M. Ben Halima ◽  
K. Sammoud ◽  
S. Boudiche ◽  
J. Ben Amar ◽  
F. Mghaieth Zghal ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cognitive Impairment ◽  
Predictive Factors ◽  
Tunisian Population

Association of cytokine Th2 gene polymorphisms with autoimmune thyroid diseases in Tunisian population

2020 ◽  
Vol 47 (3) ◽  
pp. 294-308 ◽  
Author(s):  
Souhir Mestiri ◽  
Ines Zaaber ◽  
Oumaima Inoubli ◽  
Nabil Abid ◽  
Abir Omrani ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Thyroid Diseases ◽  
Tunisian Population ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

scholarly journals Prevalence of obstructive sleep apnea in Tunisian population with atrial fibrillation: More than a simple association

2019 ◽  
Vol 11 (1) ◽  
pp. 95
Author(s):  
M. Ben Halima ◽  
K. Sammoud ◽  
Selim Boudiche ◽  
J. Ben Amar ◽  
F. Mghaieth Zghal ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Tunisian Population ◽  
Obstructive Sleep

Glutathione S-transferase M1 and T1 gene polymorphisms and risk of endometriosis in Tunisian population

2014 ◽  
Vol 18 (2) ◽  
pp. 128-133 ◽  
Author(s):  
Belkis Henidi ◽  
Safa Kaabachi ◽  
Marwa Mbarik ◽  
Amel Zhioua ◽  
Kamel Hamzaoui
Keyword(s):  
Gene Polymorphisms ◽  
Tunisian Population ◽  
Glutathione S Transferase ◽  
T1 Gene
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