Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

2016 ◽  
Vol 23 (5-6) ◽  
pp. 318-331 ◽  
Author(s):  
Dongfang Shen ◽  
Xiaoyan Tian ◽  
Wenxu Sang ◽  
Rongrong Song
Keyword(s):  
Vascular Dementia ◽  
Rat Model ◽  
Memory Impairment ◽  
Hippocampal Damage

scholarly journals Hwangryunhaedok-Tang Exerts Neuropreventive Effect on Memory Impairment by Reducing Cholinergic System Dysfunction and Inflammatory Response in a Vascular Dementia Rat Model

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 343 ◽  
Author(s):  
Eunjin Sohn ◽  
Yu Kim ◽  
Hye-Sun Lim ◽  
Bu-Yeo Kim ◽  
Soo-Jin Jeong
Keyword(s):  
Vascular Dementia ◽  
Rat Model ◽  
Memory Impairment ◽  
Neuronal Damage ◽  
Inflammatory Diseases ◽  
Ethanol Extract ◽  
Mitogen Activated Protein Kinase ◽  
Therapeutic Effects ◽  
Sprague Dawley ◽  
Cholinergic Dysfunction

Hwangryunhaedok-tang (HRT) is a traditional oriental herbal formula used in Asian countries for treating inflammatory diseases and controlling fever. Our present study aimed to determine whether HRT has therapeutic effects for patients with vascular dementia (VaD) using a bilateral common carotid artery occlusion (BCCAO) rat model and assessing spatial memory impairment and activation of neuroinflammation. BCCAO was performed in male Sprague Dawley rats to induce VaD, and oral HRT was administered daily for 30 d. Our data showed that HRT ameliorated BCCAO-induced memory and cognitive impairment in behavioral tests. In addition, HRT reversed cholinergic dysfunction and neuronal damage in the hippocampus of BCCAO rats. Furthermore, HRT attenuated microglial activation and reduced the phosphorylation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase (JNK) induced by BCCAO. Simultaneous high-performance liquid chromatography analysis of HRT using index compounds from the herbal composition revealed that both HRT ethanol extract and commercial HRT granules primarily comprise geniposide, baicalin, and berberine. Our study showed that HRT administration resulted in the prevention of neuronal injury induced by BCCAO through improvement of cholinergic dysfunction and inhibition of neuroinflammatory responses, suggesting that HRT may have potential as a treatment for VaD.

scholarly journals Protective Effects of Tao-Hong-Si-Wu Decoction on Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Lan Han ◽  
Zhaojie Ji ◽  
Weidong Chen ◽  
Dengke Yin ◽  
Fan Xu ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Memory Impairment ◽  
B Cell Lymphoma ◽  
Artery Occlusion ◽  
Hippocampal Damage ◽  
Neural Cells ◽  
Protective Effects ◽  
Thrombotic Diseases ◽  
Endothelial Growth Factor ◽  
Cerebral Artery Occlusion

Tao-Hong-Si-Wu decoction (TSD) as a traditional chinese medicine (TCM) has been developed to treat thrombotic diseases for hundreds of years, and vascular dementia (VD) is a cognitive dysfunction syndrome caused by cerebral embolism. In this study, the protective effect of TSD on memory impairment and brain damage in rat model of VD induced by middle cerebral artery occlusion (MCAO) was investigated. The study showed that rats in MCAO treatment with TSD for 14 days significantly improved behavioral function, increased densities of neuron, and induced angiogenesis in the brain compared with model rats. TSD also adjusted the neurotransmitter levels, reduced the content of endothelin-1 (ET-1), and induced the activities of vascular endothelial growth factor (VEGF) in hippocampus. Moreover, the immunohistochemical staining and western blotting results also revealed that TSD decreased apoptosis via upregulated B-cell lymphoma-2 (Bcl-2)/Bcl-2 associated X protein (Bax) ratio. These results demonstrated TSD possesses neuroprotective and antidementia properties by preventing the loss of neural cells, adjusting brain neurotransmitter, promoting cerebral blood circulation, and decreasing apoptosis. These results suggested that TSD might be developed as an effective drug for the prevention of VD.

scholarly journals Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Pratchaya Kaewkaen ◽  
Terdthai Tong-un ◽  
Jintanaporn Wattanathorn ◽  
Supaporn Muchimapura ◽  
Wiroje Kaewrueng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Vascular Dementia ◽  
Memory Impairment ◽  
Neuroprotective Effect ◽  
Hippocampal Damage ◽  
Preventive Strategy ◽  
Fruit Extract ◽  
Mulberry Fruit ◽  
Male Wistar Rats

Nowadays, the preventive strategy of vascular dementia, one of the challenge problems of elderly, has received attention due to the limitation of therapeutic efficacy. In this study, we aimed to determine the protective effect and possible mechanism of action of mulberry fruit extract on memory impairment and brain damage in animal model of vascular dementia. Male Wistar rats, weighing 300–350?g, were orally given mulberry extract at doses of 2, 10 and 50?mg/kg at a period of 7 days before and 21 days after the occlusion of right middle cerebral artery (Rt.MCAO). It was found that rats subjected to mulberry fruits plus Rt.MCAO showed the enhanced memory, the increased densities of neuron, cholinergic neuron, Bcl-2-immunopositive neuron together with the decreased oxidative stress in hippocampus. Taken all data together, the cognitive enhancing effect of mulberry fruit extract observed in this study might be partly associated with the increased cholinergic function and its neuroprotective effect in turn occurs partly via the decreased oxidative stress and apoptosis. Therefore, mulberry fruit is the potential natural cognitive enhancer and neuroprotectant. However, further researches are essential to elucidate the possible active ingredient.

scholarly journals Paeoniflorin attenuates hippocampal damage in a rat model of vascular dementia

2016 ◽  
Vol 12 (6) ◽  
pp. 3729-3734 ◽  
Author(s):  
Ying Zhang ◽  
Li-Li Wang ◽  
Yan Wu ◽  
Ning Wang ◽  
Shang-Ming Wang ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Rat Model ◽  
Hippocampal Damage

scholarly journals (-)-SCR1693 Protects against Memory Impairment and Hippocampal Damage in a Chronic Cerebral Hypoperfusion Rat Model

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xiaoyin Zhu ◽  
Jingwei Tian ◽  
Songmei Sun ◽  
Qiuju Dong ◽  
Fangxi Zhang ◽  
...  
Keyword(s):  
Rat Model ◽  
Memory Impairment ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Hippocampal Damage
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