scholarly journals Protective Effect of Low-Intensity Pulsed Ultrasound on Memory Impairment and Brain Damage in a Rat Model of Vascular Dementia

Radiology ◽  
2017 ◽  
Vol 282 (1) ◽  
pp. 113-122 ◽  
Author(s):  
Sin-Luo Huang ◽  
Chi-Wei Chang ◽  
Yi-Hsuan Lee ◽  
Feng-Yi Yang
Keyword(s):  
Protective Effect ◽  
Vascular Dementia ◽  
Brain Damage ◽  
Rat Model ◽  
Memory Impairment ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

scholarly journals Low-Intensity Pulsed Ultrasound Accelerates Osteoblast Differentiation and Promotes Bone Formation in an Osteoporosis Rat Model

Pathobiology ◽  
2009 ◽  
Vol 76 (3) ◽  
pp. 99-107 ◽  
Author(s):  
Shuliang Wu ◽  
Yumi Kawahara ◽  
Tomotaka Manabe ◽  
Kazuyuki Ogawa ◽  
Masaya Matsumoto ◽  
...  
Keyword(s):  
Bone Formation ◽  
Rat Model ◽  
Osteoblast Differentiation ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

Low-Intensity Pulsed Ultrasound Prevents Development of Bisphosphonate-Related Osteonecrosis of the Jaw-Like Pathophysiology in a Rat Model

2019 ◽  
Vol 45 (7) ◽  
pp. 1721-1732 ◽  
Author(s):  
Kouki Hidaka ◽  
Yuko Mikuni-Takagaki ◽  
Satoko Wada-Takahashi ◽  
Makiko Saita ◽  
Ryota Kawamata ◽  
...  
Keyword(s):  
Rat Model ◽  
Osteonecrosis Of The Jaw ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

scholarly journals Low-intensity pulsed ultrasound improves behavioral functions and alleviates neuroinflammation in a rat model of Parkinson’s disease

2020 ◽  
Author(s):  
Feng-Yi Yang ◽  
Chen-Yu Sung ◽  
Pai-Kai Chiang ◽  
Che-Wen Tsai
Keyword(s):  
Rat Model ◽  
Neurotrophic Factors ◽  
Neurotrophic Factor ◽  
Tissue Injury ◽  
Substantia Nigra Pars Compacta ◽  
Dopamine Level ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
The Brain

Abstract BackgroundParkinson’s disease (PD) is characterized by a reduction of dopamine level in the substantia nigra pars compacta (SNpc) and striatum of the brain. Low-intensity pulsed ultrasound (LIPUS) has been demonstrated recently as a non-invasive neuromodulation tool in a number of fields. LIPUS has also been reported to improve behavioral functions in PD animal models; however, the effect of LIPUS stimulation on the neurotrophic factors and neuroinflammation has not yet been addressed.MethodsPD rat model was built by injection of 6-hydroxydopamine (6-OHDA) in two sites in the right striatum. The levels of neurotrophic factors and lipocalin-2 (LCN2)-induced neuroinflammation were quantified using a western blot. Rotational test and cylinder test were conducted biweekly for eight weeks. The safety of LIPUS was assessed using Hematoxylin and Esosin (H&E) staining and Nissl staining.ResultsWhen the 6-OHDA+LIPUS and 6-OHDA groups were compared, the locomotor function of the 6-OHDA+LIPUS rats was significantly improved. After LIPUS stimulation, the number of neurons was remarkably increased in the striatum and SNpc of lesioned rats. Unilateral LIPUS stimulation did not increase brain-derived neurotrophic factor (BDNF) in the striatum and SNpc of lesioned rats. In contrast, unilateral LIPUS stimulation increased glial cell line-derived neurotrophic factor (GDNF) protein 1.98-fold unilaterally in the SNpc. Additionally, LCN2-induced neuroinflammation can be attenuated following LIPUS stimulation.ConclusionsOur data indicated that LIPUS stimulation increased GDNF and dopaminergic (DA) neuron density in the 6-OHDA-induced rat model of PD. Moreover, this technology attenuated proinflammatory mediators and reversed behavioral indicators of PD-associated motor dysfunction with no evidence of brain tissue injury. These results show that LIPUS stimulation may be a potential therapeutic tool against PD via enhancement of GDNF level and inhibition of inflammatory responses in the SNpc of the brain.

Effect of Low-Intensity Pulsed Ultrasound on a Rat Model of Dentin–Dental Pulp Injury and Repair

2017 ◽  
Vol 43 (1) ◽  
pp. 163-175 ◽  
Author(s):  
Fei Wang ◽  
Yueheng Li ◽  
Zhengyan Yang ◽  
Keke Lu ◽  
Jing Zuo ◽  
...  
Keyword(s):  
Rat Model ◽  
Dental Pulp ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Injury And Repair
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