scholarly journals Paeoniflorin attenuates hippocampal damage in a rat model of vascular dementia

2016 ◽  
Vol 12 (6) ◽  
pp. 3729-3734 ◽  
Author(s):  
Ying Zhang ◽  
Li-Li Wang ◽  
Yan Wu ◽  
Ning Wang ◽  
Shang-Ming Wang ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Rat Model ◽  
Hippocampal Damage

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

2016 ◽  
Vol 23 (5-6) ◽  
pp. 318-331 ◽  
Author(s):  
Dongfang Shen ◽  
Xiaoyan Tian ◽  
Wenxu Sang ◽  
Rongrong Song
Keyword(s):  
Vascular Dementia ◽  
Rat Model ◽  
Memory Impairment ◽  
Hippocampal Damage

scholarly journals Efficacy of Ulinastatin and Sulforaphane Alone or in Combination in Rat Model of Streptozotocin Diabetes Induced Vascular Dementia

2021 ◽  
Vol 19 (3) ◽  
pp. 470-489
Author(s):  
Poonam Sharma ◽  
Prachi Kaushik ◽  
Swati Jain ◽  
Brij Mohan Sharma ◽  
Rajendra Awasthi ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Rat Model ◽  
Streptozotocin Diabetes

FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia

2019 ◽  
Vol 356 ◽  
pp. 98-106 ◽  
Author(s):  
Xin Jiang ◽  
Xiaoli Niu ◽  
Qingjun Guo ◽  
Yanhong Dong ◽  
Jing Xu ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Rat Model ◽  
Neuroprotective Effects

The neuroprotective properties and therapeutic potential of epidermal neural crest stem cells transplantation in a rat model of vascular dementia

2021 ◽  
pp. 147750
Author(s):  
Somayeh Akbari ◽  
Etrat Hooshmandi ◽  
Mahnaz Bayat ◽  
Afshin Borhani Haghighi ◽  
Mohammad Saied Salehi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Vascular Dementia ◽  
Rat Model ◽  
Therapeutic Potential ◽  
Neural Crest Stem Cells ◽  
Stem Cells Transplantation

scholarly journals Hwangryunhaedok-Tang Exerts Neuropreventive Effect on Memory Impairment by Reducing Cholinergic System Dysfunction and Inflammatory Response in a Vascular Dementia Rat Model

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 343 ◽  
Author(s):  
Eunjin Sohn ◽  
Yu Kim ◽  
Hye-Sun Lim ◽  
Bu-Yeo Kim ◽  
Soo-Jin Jeong
Keyword(s):  
Vascular Dementia ◽  
Rat Model ◽  
Memory Impairment ◽  
Neuronal Damage ◽  
Inflammatory Diseases ◽  
Ethanol Extract ◽  
Mitogen Activated Protein Kinase ◽  
Therapeutic Effects ◽  
Sprague Dawley ◽  
Cholinergic Dysfunction

Hwangryunhaedok-tang (HRT) is a traditional oriental herbal formula used in Asian countries for treating inflammatory diseases and controlling fever. Our present study aimed to determine whether HRT has therapeutic effects for patients with vascular dementia (VaD) using a bilateral common carotid artery occlusion (BCCAO) rat model and assessing spatial memory impairment and activation of neuroinflammation. BCCAO was performed in male Sprague Dawley rats to induce VaD, and oral HRT was administered daily for 30 d. Our data showed that HRT ameliorated BCCAO-induced memory and cognitive impairment in behavioral tests. In addition, HRT reversed cholinergic dysfunction and neuronal damage in the hippocampus of BCCAO rats. Furthermore, HRT attenuated microglial activation and reduced the phosphorylation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase (JNK) induced by BCCAO. Simultaneous high-performance liquid chromatography analysis of HRT using index compounds from the herbal composition revealed that both HRT ethanol extract and commercial HRT granules primarily comprise geniposide, baicalin, and berberine. Our study showed that HRT administration resulted in the prevention of neuronal injury induced by BCCAO through improvement of cholinergic dysfunction and inhibition of neuroinflammatory responses, suggesting that HRT may have potential as a treatment for VaD.

P3-209: COGNITIVE IMPAIRMENT IS ASSOCIATED WITH PREMATURE ARTERIAL STIFFENING, AORTIC WALL FIBROSIS AND INCREASED BLOOD PRESSURE: A NOVEL RAT MODEL OF AGE-DEPENDENT VASCULAR DEMENTIA

2006 ◽  
Vol 14 (7S_Part_21) ◽  
pp. P1149-P1150
Author(s):  
Olga V. Fedorova ◽  
Yulia Grigorova ◽  
Madeleine Hagood ◽  
Jeffrey Long ◽  
Ross McDevitt ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cognitive Impairment ◽  
Vascular Dementia ◽  
Rat Model ◽  
Aortic Wall ◽  
Arterial Stiffening ◽  
Age Dependent

Capillary loss precedes the cognitive impairment induced by fractionated whole-brain irradiation: A potential rat model of vascular dementia

2007 ◽  
Vol 257 (1-2) ◽  
pp. 67-71 ◽  
Author(s):  
William R. Brown ◽  
Robert M. Blair ◽  
Dixon M. Moody ◽  
Clara R. Thore ◽  
Stephanie Ahmed ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Vascular Dementia ◽  
Rat Model ◽  
Whole Brain Irradiation ◽  
Whole Brain ◽  
Brain Irradiation
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