scholarly journals Diaminodiphenyl Sulfone-Induced Hemolytic Anemia and Alopecia in a Case of Linear IgA Bullous Dermatosis

2015 ◽  
Vol 7 (2) ◽  
pp. 183-186 ◽  
Author(s):  
Eijiro Akasaka ◽  
Sato-Jin Kayo ◽  
Hajime Nakano ◽  
Norito Ishii ◽  
Takashi Hashimoto ◽  
...  
Keyword(s):  
Side Effects ◽  
Hemolytic Anemia ◽  
Hair Loss ◽  
Laboratory Data ◽  
Immunoglobulin A ◽  
Deficiency Anemia ◽  
Diaminodiphenyl Sulfone ◽  
First Line Therapy ◽  
Bullous Dermatosis ◽  
Linear Iga Bullous Dermatosis

Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is an autoimmune mucocutaneous disease characterized by subepidermal blistering induced by IgA autoantibodies against several autoantigens in the basal membranous zone of the skin and mucosal tissue. Although diaminodiphenyl sulfone (DDS), also known as dapsone, is generally recognized as the first-line therapy for LABD, DDS can induce several severe side effects. We present a Japanese case of LABD with DDS-induced hemolytic anemia and alopecia. In the present case, the DDS-induced hemolytic anemia and hair loss made the DDS monotherapy difficult. When DDS is used in LABD patients with iron deficiency anemia (IDA), hemolytic anemia is concealed by IDA. It is thus necessary to carefully and frequently examine the laboratory data to find the signs of DDS-induced hemolytic anemia. Even though there is no literature on DDS-induced alopecia, alopecia was reported as one of the side effects of DDS in an FDA report, and, in our case, hair loss was improved after reducing its dosage. We have to recognize that alopecia is one of the side effects of DDS and that careful management is needed in order not to overlook the adverse side effects of DDS when treating LABD patients.

scholarly journals A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Pinky Jha ◽  
Kurtis Swanson ◽  
Jeremiah Stromich ◽  
Basia M. Michalski ◽  
Edit Olasz
Keyword(s):  
Joint Infection ◽  
Immunoglobulin A ◽  
Colchicine Treatment ◽  
Left Knee ◽  
Dermoepidermal Junction ◽  
Common Drug ◽  
Prosthetic Joint ◽  
Bullous Dermatosis ◽  
History Of ◽  
Linear Iga Bullous Dermatosis

Linear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vancomycin. It is best characterized pathologically by subepidermal bulla (blister) formation with linear IgA deposition at the dermoepidermal junction. Here we report an 86-year-old male with a history of left knee osteoarthritis who underwent a left knee arthroplasty and subsequently developed a prosthetic joint infection. This infection was treated with intravenous vancomycin as well as placement of a vancomycin impregnated joint spacer. Five days following initiation of antibiotic therapy, he presented with a vesiculobullous eruption on an erythematous base over his trunk, extremities, and oral mucosa. The eruption resolved completely when intravenous vancomycin was discontinued and colchicine treatment was begun. Curiously, complete resolution occurred despite the presence of the vancomycin containing joint spacer. The diagnosis of vancomycin-induced linear IgA bullous dermatosis was made based on characteristic clinical and histopathologic presentations.

scholarly journals Linear IgA bullous dermatosis: report of an exuberant case

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 67-70 ◽  
Author(s):  
Beatriz Cavalcanti de Souza ◽  
Nádire Cristina Freire Pontes Fregonesi ◽  
Antônio José Tebcherani ◽  
Ana Paula Galli Sanchez ◽  
Valéria Aoki ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Response To Treatment ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease ◽  
Bullous Dermatosis ◽  
Linear Iga Dermatosis ◽  
Linear Iga Bullous Dermatosis

Linear immunoglobulin A dermatosis is a rare autoimmune bullous disease, but the most common autoimmune bullous dermatosis in children. We report a typical exuberant case of linear IgA dermatosis in a ten-month old child, who showed good response to treatment with corticosteroids and dapsone.

scholarly journals Vancomycin and linear IgA bullous dermatosis

2018 ◽  
Vol 6 (22) ◽  
pp. 38-41
Author(s):  
Amr Ismail ◽  
Rocio Gavidia Quezada ◽  
Kenneth Iwuji ◽  
Abdussalam Shredi ◽  
Michelle Tarbox
Keyword(s):  
Health Care ◽  
Staphylococcus Aureus ◽  
Side Effects ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
First Line ◽  
Broad Spectrum Antibiotic ◽  
Skin Reactions ◽  
Bullous Dermatosis ◽  
Linear Iga Bullous Dermatosis ◽  
Health Care Associated Infection

Vancomycin is a broad-spectrum antibiotic that is considered an optimal parenteraltreatment for many infections, including septicemia, pneumonia, cellulitis, endocarditis, andmeningitis caused by methicillin-resistant Staphylococcus aureus. It is the first-line treatmentfor the increasing health care-associated infection Clostridium difficile pseudomembranouscolitis. More side effects are being reported secondary to increased vancomycin use. Of thoseside effects, skin reactions are becoming more recognized by physicians.

scholarly journals Glycopeptide Hypersensitivity and Adverse Reactions

Pharmacy ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 70
Author(s):  
Vanthida Huang ◽  
Nicola A. Clayton ◽  
Kimberly H. Welker
Keyword(s):  
Immunoglobulin E ◽  
Immunoglobulin A ◽  
Infusion Reaction ◽  
Cross Reactivity ◽  
First Line ◽  
First Line Therapy ◽  
Clostridioides Difficile ◽  
Immune Mediated ◽  
Bullous Dermatosis ◽  
Ige Mediated

Glycopeptides, such as vancomycin and teicoplanin, are primarily used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections, such as cellulitis, endocarditis, meningitis, pneumonia, and septicemia, and are some of the most commonly prescribed parenteral antimicrobials. Parenteral glycopeptides are first-line therapy for severe MRSA infections; however, oral vancomycin is used as a first-line treatment of Clostridioides difficile infections. Also, we currently have the longer-acting lipoglycopeptides, such as dalbavancin, oritavancin, and telavancin to our armamentarium for the treatment of MRSA infections. Lastly, vancomycin is often used as an alternative treatment for patients with β-lactam hypersensitivity. Common adverse effects associated with glycopeptide use include nephrotoxicity, ototoxicity, and Redman Syndrome (RMS). The RMS is often mistaken for a true allergy; however, it is a histamine-related infusion reaction rather than a true immunoglobulin E (IgE)-mediated allergic reaction. Although hypersensitivity to glycopeptides is rare, both immune-mediated and delayed reactions have been reported in the literature. We describe the various types of glycopeptide hypersensitivity reactions associated with glycopeptides and lipoglycopeptides, including IgE-mediated reactions, RMS, and linear immunoglobulin A bullous dermatosis, as well as describe cross-reactivity with other glycopeptides.

scholarly journals Pernicious Anemia with Autoimmune Hemolytic Anemia: A Case Report and Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Sri Lakshmi Hyndavi Yeruva ◽  
Raj Pal Manchandani ◽  
Patricia Oneal
Keyword(s):  
Pernicious Anemia ◽  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
Clinical Presentation ◽  
Laboratory Data ◽  
Vitamin B12 Deficiency ◽  
Deficiency Anemia ◽  
Severe Anemia ◽  
History Of ◽  
B12 Deficiency

Pernicious anemia is a common cause of vitamin B12 deficiency. Here, we discuss a case of a young woman who presented with severe anemia along with a history of iron deficiency anemia. After a review of her clinical presentation and laboratory data, we identified an autoimmune hemolytic anemia and a concomitant pernicious anemia. The concurrence of both these hematological diagnoses in a patient is rare.

scholarly journals Lactoferrin Efficacy versus Ferrous Sulfate in Treatment of Children with Iron Deficiency Anemia

2021 ◽  
Vol 11 (01) ◽  
pp. e199-e204
Author(s):  
Osama Mahmoud El-Asheer ◽  
Ahmed Gaber Ahmed ◽  
Zainab AbdelAal Abdel Hafez ◽  
Marwa AbdelHafiz Dahpy ◽  
Amal AbdElSalam Soliman
Keyword(s):  
Side Effects ◽  
Iron Deficiency ◽  
Patient Compliance ◽  
Iron Deficiency Anemia ◽  
Ferrous Sulfate ◽  
Serum Iron ◽  
Deficiency Anemia ◽  
Serum Transferrin ◽  
Iron Binding ◽  
Clinical Benefits

AbstractLactoferrin (LF) is an iron-binding globular glycoprotein that is structurally and chemically similar to serum transferrin. Many studies have been done to evaluate the effect of oral LF administration on iron deficiency anemia (IDA) with controversial results. This study was designed to compare the efficacy of LF versus oral ferrous sulfate (OFS) therapy in the treatment of children with IDA. A significant increase in mean hemoglobin and serum iron concentrations was noted in the group that received oral bovine LF (11.06 ± 0.96 and 42.79 ± 6.14, respectively) versus the group that received OFS (10.24 ± 0.57 and 28.94 ± 5.05, respectively, with p < 0.001 for each) after 30 days of the treatment with fewer side effects (9.3 vs. 33.3% with p = 0.043). Oral bovine LF is a more effective and safer alternative in treating iron deficiency and IDA compared with OFS with clinical benefits of fewer side effects and better patient compliance.

Sign in / Sign up

Export Citation Format

Share Document