scholarly journals Pernicious Anemia with Autoimmune Hemolytic Anemia: A Case Report and Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Sri Lakshmi Hyndavi Yeruva ◽  
Raj Pal Manchandani ◽  
Patricia Oneal
Keyword(s):  
Pernicious Anemia ◽  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
Clinical Presentation ◽  
Laboratory Data ◽  
Vitamin B12 Deficiency ◽  
Deficiency Anemia ◽  
Severe Anemia ◽  
History Of ◽  
B12 Deficiency

Pernicious anemia is a common cause of vitamin B12 deficiency. Here, we discuss a case of a young woman who presented with severe anemia along with a history of iron deficiency anemia. After a review of her clinical presentation and laboratory data, we identified an autoimmune hemolytic anemia and a concomitant pernicious anemia. The concurrence of both these hematological diagnoses in a patient is rare.

Anemia profile in Diabetic patients with preserved renal function

2021 ◽  
Vol 12 (2) ◽  
pp. 54-58
Author(s):  
Vinay Krishnamurthy ◽  
Akhila Rao Kerekoppa
Keyword(s):  
Renal Function ◽  
General Population ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Deficiency Anemia ◽  
Diabetic Patients ◽  
Severe Anemia ◽  
B12 Deficiency ◽  
Anemia Of Inflammation ◽  
Prevalence Of Anemia

Background: Diabetes is one of the largest global health emergencies of the 21st century. Prevalence of anemia in diabetic patients is two to three times higher than for patients with comparable renal impairment and iron stores in the general population. Aims and Objective: This study was done to analyse the prevalence of anemia and its profile in patients with preserved renal function. Materials and Methods: One-hundred diabetic patients with anemia with normal renal functions were selected. Complete blood count, peripheral blood smear, iron studies, vitamin B12 levels were assessed. Diabetic control was monitored by HbA1c. Patients were identified to have specific type of anemia, based on iron profile and vitamin B12 levels. Severity of anemia was also assessed. Appropriate statistical tests were applied to analyse the results. Results: Mean age of subjects in the study group was 53.4±13.6 years. The mean haemoglobin level was 9.41±2.18 g/dl. Out of the 100 cases, 43 patients had iron deficiency anemia, 40 patients had anemia of inflammation, and 8 patients had vitamin B12 deficiency, 8 patients had combined iron and vitamin B12 deficiency, and 1 patient had pancytopenia. Mean HbA1c was higher in iron deficient individuals with a significant p value and mean HbA1c was lower in Vitamin B12 deficient individuals. Among the cases, 16% had mild anemia, 61% had moderate anemia, and 23% had severe anemia. Severe anemia had a significantly lower HbA1c, which was statistically significant. Conclusion: According to our study, iron deficiency anemia was the commonest, followed by anemia of inflammation in diabetic patients with preserved renal function. Diabetes being a pro-inflammatory state had a higher incidence of anemia of inflammation compared to general population. We have to identify and acknowledge the higher prevalence of Anemia of Inflammation in diabetic patients in the absence of renal dysfunction.

scholarly journals A Puzzle of Hemolytic Anemia, Iron and Vitamin B12 Deficiencies in a 52-Year-Old Male

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Suartcha Prueksaritanond ◽  
Aram Barbaryan ◽  
Aibek E. Mirrakhimov ◽  
Palacci Liana ◽  
Alaa M. Ali ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Hemolytic Anemia ◽  
Transferrin Saturation ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Deficiency Anemia ◽  
Significant Past Medical History ◽  
Distribution Width ◽  
Serum Haptoglobin ◽  
B12 Deficiency

A 52-year-old male with no significant past medical history reports increasing generalized fatigue and weakness for the past 2 weeks. Physical examination reveals jaundice and pallor without organomegaly or lymphadenopathy. His hemoglobin was 5.9 g/dL with a mean corpuscular volume of 87.1 fL and elevated red blood cell distribution width of 30.7%. His liver function test was normal except for elevated total bilirubin of 3.7 mg/dL. Serum LDH was 701 IU/L, and serum haptoglobin was undetectable. Further investigation revealed serum vitamin B12 of <30 pg/mL with elevated methylmalonic acid and homocysteine level. In addition, serum ferritin and transferrin saturation were low. The patient was diagnosed with hemolytic anemia secondary to vitamin B12 deficiency with concomitant iron deficiency anemia.

scholarly journals Microcytic Anemia Hiding Vitamin B12 Deficiency Anemia

Cureus ◽  
2021 ◽  
Author(s):  
Fadi Busaleh ◽  
Omkolthoom A Alasmakh ◽  
Fatimah Almohammedsaleh ◽  
Maram F Almutairi ◽  
Juwdaa S Al Najjar ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Microcytic Anemia ◽  
Deficiency Anemia ◽  
B12 Deficiency

scholarly journals Study of aetiology of anemia in HIV positive individuals

2021 ◽  
Vol 8 (4) ◽  
pp. 546
Author(s):  
Umamaheshwari S. ◽  
Varun Venkat Raghavan ◽  
Ramamurthy P. ◽  
Krishna Kumar Naik T.
Keyword(s):  
Chronic Disease ◽  
Vitamin B12 Deficiency ◽  
Deficiency Anemia ◽  
Hiv Positive ◽  
Medical Sciences ◽  
Immunological Status ◽  
Global Pandemic ◽  
B12 Deficiency ◽  
Anemia Patient ◽  
Severe Grade

Background: HIV/AIDS is a global pandemic. As of 2014, approximately 37 million people have HIV worldwide with the number of new infections that year being about 2 million. This is down from 3.1 million new infections in 2001. The objective of the study was to study the immunological status as indicated by the CD4 count and aetiology of anemia in HIV positive individuals.Methods: This study was carried out on 100 consecutive HIV patients in the Department of Medicine, Vijayanagara Institute of Medical Sciences Bellary, Karnataka during the period from October 2014 to May 2016.Results: In this study, 100 patients with HIV infection and anemia were studied to find the etiology of anemia in HIV positive patients Only patients with Hb less than 10 g/dl (moderate to severe grade) were included in this study. 42% patient had moderate grade anemia and 58% had severe grade anemia patient mild grade anemia was excluded. 13 patient had their MCV <76 fl. 60 patient had their MCV between 76-96 fl and 27% had their MCV of >96 fl. 54% of patient had anemia due to chronic disease.Conclusions: 54% of patient had anemia due to chronic disease, 12% had iron deficiency anemia, 11% had anemia due to vitamin B12 deficiency, 22 % had anemia due to zidovudine induced anemia and 1 patient had anemia due hemolysis. 

Metabolic Interrelationship between Vitamin B12 and Ascorbic Acid in Pernicious Anemia

Blood ◽  
1968 ◽  
Vol 31 (1) ◽  
pp. 55-65 ◽  
Author(s):  
SIGMUND BENHAM KAHN ◽  
ISADORE BRODSKY ◽  
Sandra A. Fein
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Vitamin B12 Deficiency ◽  
Biochemical Index ◽  
Plasma Ascorbate ◽  
B12 Deficiency ◽  
Future Work

Abstract An interrelationship between vitamin C and vitamin B12 was studied in three patients with vitamin B12 deficiency associated with pernicious anemia. Subnormal plasma ascorbate concentrations were found prior to therapy confirming previous observations. Following vitamin B12 administration and utilizing methylmalonate (MMA) excretion as a biochemical index of vitamin B12 deficiency, low plasma ascorbate concentrations persisted until MMA excretion was abolished. In two patients, RBC vitamin B12 activity was also serially measured in order to evaluate its sensitivity as an index of vitamin B12 stores when compared to MMA excretion. The data demonstrate that in these two vitamin B12-deficient patients undergoing slow repletion therapy, RBC vitamin B12 activity returns to normal before MMA excretion is abolished. Whether continued MMA excretion in these patients indicates a greater sensitivity of MMA excretion as an index of deficiency of vitamin B12 stores than does RBC vitamin B12 activity remains to be answered by future work.

scholarly journals Hematologic Manifestations of Vitamin B12 Deficiency in Swine

Blood ◽  
1951 ◽  
Vol 6 (10) ◽  
pp. 867-891 ◽  
Author(s):  
G. E. CARTWRIGHT ◽  
BETTY TATTING ◽  
JEAN ROBINSON ◽  
N. M. FELLOWS ◽  
F. D. GUNN ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Vitamin B12 ◽  
Liver Damage ◽  
Megaloblastic Anemia ◽  
Macrocytic Anemia ◽  
Vitamin B12 Deficiency ◽  
Deficiency Anemia ◽  
Severe Neutropenia ◽  
Pteroylglutamic Acid ◽  
B12 Deficiency

Abstract In an effort to produce a deficiency of vitamin B12 a total of 70 pigs were fed a purified diet containing soybean alpha protein in place of casein. One group of animals was started on the diet at 2 to 7 days of age. A second group began at 21 to 28 days of age. Methionine, iodinate casein, desiccated thyroid and pteroylglutamic acid were added to the diet of certain animals and! omitted from the diet of other pigs. In addition, 9 pigs were gastrectomized. Forty-three of the animals survived for a sufficiently long period of time for adequate evaluation of the results of the experiment. Severe liver damage was observed in 24 of the 25 animals autopsied. The only animal not showing liver damage received vitamin B12 from the beginning of the experiment. Necrosis of the liver cells, fatty infiltration, or both, occurred in the presence of a high fat diet containing apparently adequate amounts of protein, choline, vitamin E and methionine. These pathologic changes were apparently prevented but not reversed by the administration of vitamin B12. Growth of the animals on the above diets without added vitamin B12 was retarded as compared with the growth of animals on the same diet supplemented with this vitamin. The administration of vitamin B12 to the deficient animals resulted in rapid growth. Of the 39 animals not receiving vitamin B12 13 failed to develop anemia, 16 developed a mild anemia and in 10 a moderately severe anemia was present. When present the anemia was normocytic and in 24 pigs was accompanied by a moderately severe neutropenia. Differential cell counts on the sternal marrow were normal except for a slight increase in the proportion of normoblasts. These hematologic alterations were neither consistently or completely corrected by the administration of vitamin B12 in spite of the fact that definite and sometimes marked reticulocyte increases followed. When methionine deficiency was associated with vitamin B12 deficiency, anemia appeared to be more severe. The administration of aureomycin, an "animal protein factor," did not stimulate growth and failed to induce a hemopoietic response. There was no macrocytic anemia, the bone marrow was not megaloblastic, and neurologic disturbances or morphologic alterations in the neutrophils were not observed. These results are in contrast to those obtained in pigs with an experimentally produced deficiency of pteroylglutamic acid. Such animals develop macrocytic anemia, leukopenia and a macronormoblastic type of bone marrow. It is not possible to give with any assurance the reason why megaloblastic anemia was not produced in the "B12-deficient" animals. This may have been due to the fact that (1) the deficiency was not sufficiently severe to result in such a change in the hemopoietic system; or (2) because pteroylglutamic acid prevents the development of megaloblastic anemia even in the absence of vitamin B12.

scholarly journals Vitamin B12 Deficiency Anemia and Polyneuropathy Due to Chronic Radiation Enteritis

2020 ◽  
Vol 59 (6) ◽  
pp. 859-861
Author(s):  
Hiroyuki Fukuda ◽  
Munetaka Takekuma ◽  
Yasuyuki Hirashima
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Radiation Enteritis ◽  
Deficiency Anemia ◽  
Chronic Radiation ◽  
B12 Deficiency
Sign in / Sign up

Export Citation Format

Share Document