Linear IGA bullous dermatosis potentially triggered by vaccination

Linear IgA bullous dermatosis (LABD) is a mucocutaneous autoimmune blistering disease affecting both adults and children. It is caused by IgA antibodies targeting multiple antigens along the basement membrane zone, leading to disruption of dermoepidermal junction and development of bullous lesions which often presents in characteristic arrangement. Although most LABD cases have been reported to be idiopathic, different triggers have been described, including several drugs and infection. However, the occurrence of vaccine-induced cases of LABD is not widely known and accepted due to the few reports available. We present two cases of LABD occurred following different triggers, rising the suspicion for a possible pathogenetic role of vaccines.

Linear IgA bullous dermatosis

Linear IgA bullous dermatosis is a rare autoimmune blistering disorder, afecting both children and adults. The goal of this review is to summarize the clinical, diagnostic, and therapeutic aspects of the disease. Subepidermal, tense blisters, urticariform plaques and erosions develop on the skin, typically in a grouped pattern. Annularly arranged lesions are referred to as “cluster of jewels”, while lesions forming a linear or arched pattern are named “string of pearls”. Mucosal involvement is also present in some cases, and scarring may lead to permanent complications. Specifc autoimmune diagnostic tests are essential for the defnitive diagnosis. The frst line treatment is dapsone and the disease shows a benign course in most cases.