Role of Elemental Diet in Dermatitis herpetiformis

2015 ◽  
pp. 176-179 ◽  
Author(s):  
Jan B. van der Meer ◽  
Nico Zeedijk ◽  
Pieter C. van Voorst Vader ◽  
Marcelus C. J. M. de Jong
Keyword(s):  
Dermatitis Herpetiformis ◽  
Elemental Diet

scholarly journals Correlation between IL-36α and IL-17 and Activity of the Disease in Selected Autoimmune Blistering Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Agnieszka Żebrowska ◽  
Anna Woźniacka ◽  
Katarzyna Juczyńska ◽  
Kamila Ociepa ◽  
Elżbieta Waszczykowska ◽  
...  
Keyword(s):  
Dermatitis Herpetiformis ◽  
Tissue Injury ◽  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Control Group ◽  
Specific Antibodies ◽  
Relevant Role ◽  
Skin Conditions ◽  
Autoimmune Blistering Diseases

Dermatitis herpetiformis (DH), bullous pemphigoid (BP), and pemphigus vulgaris (PV) are autoimmune bullous skin conditions with eosinophilic and neutrophilic infiltrations. While cytokines are crucial for the affinity and activation of different leukocyte cells in the inflammation and blister formation, there are no studies concerning a role of IL-36. The goal of the study was to analyze whether interleukin 36 is involved in pathogenesis of DH, BP, and PV. And the second aim of the study was the estimation of correlation between IL-36 and IL-17 and titers of specific antibodies in these diseases. Expression of IL-36 and IL-17 was detected in serum in all DH, BP, and PV samples. Serum levels of IL-36 and IL-17α were statistically higher in DH, BP, and PV groups as compared to the control group. IL-36α levels were statistically higher in DH patients, as compared to patients with PV and BP. Our results showed that IL-36 may be helpful in the diagnostic and monitoring of the activity of the disease. IL-36 may play a relevant role of enrolling eosinophils and neutrophils in DH, BP, and PV and finally provoke tissue injury.

scholarly journals HISTOPATHOLOGICAL AND IMMUNOFLUORESCENT STUDIES IN CERTAIN SKIN DISORDERS

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Rekha S ◽  
Vineet Kumar ◽  
Vanita Kumar ◽  
R D Mehta
Keyword(s):  
Lichen Planus ◽  
Dermatitis Herpetiformis ◽  
Direct Immunofluorescence ◽  
Skin Disorders ◽  
Immunological Mechanism ◽  
Medical College ◽  
Skin Biopsy Specimen ◽  
Immunofluorescent Technique ◽  
Skin Biopsies

Background: This study was an attempt to evaluate the role of direct immunofluorescent technique to demonstrate the immunoglobulins in certain skin disorders, which are likely to have immunological mechanism in their pathogenesis. Methods: This study was carried out in department of Pathology, Sardar Patel Medical College & Associated group of Hospitals, Bikaner. This study was hospital based study on skin biopsy specimen recieved in the department of Pathology during the study period. Results: On immunofluorescent studies of these skin biopsies, 12 out of 16 cases of pemphigus were positive for fluorescence was intracellular area in epidermis. In lichen planus  5 out of 7 cases were positive for fluorescence and commonest site was dermo-epideremal junction. In dermatis-herpatiformis 2 out of 3cases were positive for fluorescence and commonest site was dermo-epideremal junction. IgG was commonest type of immunoglobulin’s demonstrate in 12 out of 16 cases of pemphigus followed by IgM (5 cases), IgA(1cases). In lichen planus  IgM was commonest type of immunoglobulin’s demonstrate in 5 out of 7 cases of pemphigus followed by IgG (3 cases), IgA(1cases). In dermatitis herpatiformis IgA was commonest type of immunoglobulin’s demonstrate in 2 out of 3 cases of pemphigus followed by IgM (1 cases). Conclusion: We conclude that the demonstration of immunoglobulins in skin biopsies by direct fluorescent technique is a quite useful adjunct in diagnostic confirmation of pemphigus, lichen planus and dermatitis herpetiformis. Keywords: Direct immunofluorescence, Pemphigus, Histopathology.

What is the Role of Gluten in Dermatitis Herpetiformis?

1979 ◽  
Vol 24 (4) ◽  
pp. 326-326
Author(s):  
J. N. Blackwell ◽  
R. St. C. Barnetson ◽  
H. M. Gilmour ◽  
A. Ferguson ◽  
R. C. Heading
Keyword(s):  
Dermatitis Herpetiformis

scholarly journals The Role of Intereukin-31 in Pathogenesis of Itch and Its Intensity in a Course of Bullous Pemphigoid and Dermatitis Herpetiformis

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Lilianna Kulczycka-Siennicka ◽  
Anna Cynkier ◽  
Elżbieta Waszczykowska ◽  
Anna Woźniacka ◽  
Agnieszka Żebrowska
Keyword(s):  
Signaling Pathway ◽  
Bullous Pemphigoid ◽  
Dermatitis Herpetiformis ◽  
Subjective Symptoms ◽  
Autoimmune Blistering Disease ◽  
Stat Signaling ◽  
Blistering Disease ◽  
Autoimmune Blistering Diseases

Itch which is one of the major, subjective symptoms in a course of bullous pemphigoid and dermatitis herpetiformis makes those two diseases totally different than other autoimmune blistering diseases. Its pathogenesis is still not fully known. The aim of this research was to assess the role of IL-31 in development of itch as well as to measure its intensity. Obtained results, as well as literature data, show that lower concentration of IL-31 in patients’ serum may be correlated with its role in JAK/STAT signaling pathway which is involved in development of autoimmune blistering disease. Intensity of itch is surprisingly huge problem for the patients and the obtained results are comparable with results presented by atopic patients.

scholarly journals The many faces of the problem of intolerance to gluten.

2018 ◽  
Vol 96 (2) ◽  
pp. 123-128
Author(s):  
M. A. Livsan ◽  
M. F. Osipenko ◽  
Natalya V. Zayakina ◽  
T. S. Krolevets
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Current Data ◽  
Gluten Sensitivity ◽  
Wheat Allergy ◽  
Serological Markers ◽  
Gluten Intolerance ◽  
Rising Incidence ◽  
The Many

Rising incidence of different variants of gluten intolerance associated with changes in eating behaviorin many countries, changes in the technology of growing and processing crops, new culinary technologies. Until recently, celiac disease, dermatitis herpetiformis and wheat allergy were the only known disease with a proven role of gluten in their pathogenesis. Non-celiac gluten sensitivity (NCGS) - a new syndrome of intolerance to gluten. This pathology can be suspected in patients with persistent intestinal and extra-intestinal symptoms clearly associated with the intake of foods containing gluten, the absence of serological markers of celiac disease or suspected allergy to wheat. The paper presents the current data on the epidemiology, etiology and pathogenesis, clinical features and diagnosis NCGS.

scholarly journals Eosinophilic esophagitis in children: Updates and practical aspects of management for allergists in a non‐tertiary care private practice setup

2022 ◽  
Vol 43 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Ejaz Yousef ◽  
Yelena Korotkaya ◽  
Alyson B. Simpson
Keyword(s):  
Eosinophilic Esophagitis ◽  
Private Practice ◽  
Immunoglobulin E ◽  
Therapeutic Option ◽  
Tertiary Care ◽  
Elemental Diet ◽  
Dietary Therapy ◽  
Steady Increase ◽  
Esophageal Mucosa

Background: Eosinophilic esophagitis (EoE) is a chronic immune and/or antigen-mediated disease characterized by eosinophilic infiltration of mucosa (≥15 eosinophils per high power field) without any secondary etiology. Non‐immunoglobulin E mediated mechanisms predominate in EoE. Objective: This review concentrated on a stepwise approach for the allergist working in non‐tertiary care private practice. Methods: A medical literature search that focused on several areas of the latest developments in the diagnosis and management of EoE was conducted. Results: There has been a steady increase in the prevalence and incidence of EoE. Clinical symptoms can vary from dysphagia to failure to thrive, depending on the age at presentation; some children develop adaptive behaviors to compensate for dysphagia, such as food preferences and slow eating. The diagnosis is based on a high index of clinical suspicion and is confirmed with endoscopy with biopsies after ruling out other causes of esophageal eosinophilia. Treatment options may include dietary therapy, pharmacologic therapies, or combination therapy. Therapeutic options may also include endoscopic dilation for stricturing disease. Conclusion: Providers should be aware of recent recommendation changes in the diagnostic workup, the role of skin-prick testing, and role of the proton-pump inhibitor as first-line therapy for EoE. Also, clinicians should be aware of the emerging role of empiric dietary therapy as a preferable therapeutic option when compared with the testing-directed diet and the elemental diet. Furthermore, topical glucocorticoid therapies are available, and new developing therapies are being investigated. Reevaluation of esophageal mucosa with biopsies is required approximately 2 months after therapy for a response and after a change in therapies to confirm continued resolution.

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