The Role of Diet in Dermatitis herpetiformis

2015 ◽  
pp. 168-175 ◽  
Author(s):  
Timo Reunala
Keyword(s):  
Dermatitis Herpetiformis

scholarly journals Correlation between IL-36α and IL-17 and Activity of the Disease in Selected Autoimmune Blistering Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Agnieszka Żebrowska ◽  
Anna Woźniacka ◽  
Katarzyna Juczyńska ◽  
Kamila Ociepa ◽  
Elżbieta Waszczykowska ◽  
...  
Keyword(s):  
Dermatitis Herpetiformis ◽  
Tissue Injury ◽  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Control Group ◽  
Specific Antibodies ◽  
Relevant Role ◽  
Skin Conditions ◽  
Autoimmune Blistering Diseases

Dermatitis herpetiformis (DH), bullous pemphigoid (BP), and pemphigus vulgaris (PV) are autoimmune bullous skin conditions with eosinophilic and neutrophilic infiltrations. While cytokines are crucial for the affinity and activation of different leukocyte cells in the inflammation and blister formation, there are no studies concerning a role of IL-36. The goal of the study was to analyze whether interleukin 36 is involved in pathogenesis of DH, BP, and PV. And the second aim of the study was the estimation of correlation between IL-36 and IL-17 and titers of specific antibodies in these diseases. Expression of IL-36 and IL-17 was detected in serum in all DH, BP, and PV samples. Serum levels of IL-36 and IL-17α were statistically higher in DH, BP, and PV groups as compared to the control group. IL-36α levels were statistically higher in DH patients, as compared to patients with PV and BP. Our results showed that IL-36 may be helpful in the diagnostic and monitoring of the activity of the disease. IL-36 may play a relevant role of enrolling eosinophils and neutrophils in DH, BP, and PV and finally provoke tissue injury.

scholarly journals HISTOPATHOLOGICAL AND IMMUNOFLUORESCENT STUDIES IN CERTAIN SKIN DISORDERS

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Rekha S ◽  
Vineet Kumar ◽  
Vanita Kumar ◽  
R D Mehta
Keyword(s):  
Lichen Planus ◽  
Dermatitis Herpetiformis ◽  
Direct Immunofluorescence ◽  
Skin Disorders ◽  
Immunological Mechanism ◽  
Medical College ◽  
Skin Biopsy Specimen ◽  
Immunofluorescent Technique ◽  
Skin Biopsies

Background: This study was an attempt to evaluate the role of direct immunofluorescent technique to demonstrate the immunoglobulins in certain skin disorders, which are likely to have immunological mechanism in their pathogenesis. Methods: This study was carried out in department of Pathology, Sardar Patel Medical College & Associated group of Hospitals, Bikaner. This study was hospital based study on skin biopsy specimen recieved in the department of Pathology during the study period. Results: On immunofluorescent studies of these skin biopsies, 12 out of 16 cases of pemphigus were positive for fluorescence was intracellular area in epidermis. In lichen planus  5 out of 7 cases were positive for fluorescence and commonest site was dermo-epideremal junction. In dermatis-herpatiformis 2 out of 3cases were positive for fluorescence and commonest site was dermo-epideremal junction. IgG was commonest type of immunoglobulin’s demonstrate in 12 out of 16 cases of pemphigus followed by IgM (5 cases), IgA(1cases). In lichen planus  IgM was commonest type of immunoglobulin’s demonstrate in 5 out of 7 cases of pemphigus followed by IgG (3 cases), IgA(1cases). In dermatitis herpatiformis IgA was commonest type of immunoglobulin’s demonstrate in 2 out of 3 cases of pemphigus followed by IgM (1 cases). Conclusion: We conclude that the demonstration of immunoglobulins in skin biopsies by direct fluorescent technique is a quite useful adjunct in diagnostic confirmation of pemphigus, lichen planus and dermatitis herpetiformis. Keywords: Direct immunofluorescence, Pemphigus, Histopathology.

What is the Role of Gluten in Dermatitis Herpetiformis?

1979 ◽  
Vol 24 (4) ◽  
pp. 326-326
Author(s):  
J. N. Blackwell ◽  
R. St. C. Barnetson ◽  
H. M. Gilmour ◽  
A. Ferguson ◽  
R. C. Heading
Keyword(s):  
Dermatitis Herpetiformis

scholarly journals The Role of Intereukin-31 in Pathogenesis of Itch and Its Intensity in a Course of Bullous Pemphigoid and Dermatitis Herpetiformis

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Lilianna Kulczycka-Siennicka ◽  
Anna Cynkier ◽  
Elżbieta Waszczykowska ◽  
Anna Woźniacka ◽  
Agnieszka Żebrowska
Keyword(s):  
Signaling Pathway ◽  
Bullous Pemphigoid ◽  
Dermatitis Herpetiformis ◽  
Subjective Symptoms ◽  
Autoimmune Blistering Disease ◽  
Stat Signaling ◽  
Blistering Disease ◽  
Autoimmune Blistering Diseases

Itch which is one of the major, subjective symptoms in a course of bullous pemphigoid and dermatitis herpetiformis makes those two diseases totally different than other autoimmune blistering diseases. Its pathogenesis is still not fully known. The aim of this research was to assess the role of IL-31 in development of itch as well as to measure its intensity. Obtained results, as well as literature data, show that lower concentration of IL-31 in patients’ serum may be correlated with its role in JAK/STAT signaling pathway which is involved in development of autoimmune blistering disease. Intensity of itch is surprisingly huge problem for the patients and the obtained results are comparable with results presented by atopic patients.

scholarly journals The many faces of the problem of intolerance to gluten.

2018 ◽  
Vol 96 (2) ◽  
pp. 123-128
Author(s):  
M. A. Livsan ◽  
M. F. Osipenko ◽  
Natalya V. Zayakina ◽  
T. S. Krolevets
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Current Data ◽  
Gluten Sensitivity ◽  
Wheat Allergy ◽  
Serological Markers ◽  
Gluten Intolerance ◽  
Rising Incidence ◽  
The Many

Rising incidence of different variants of gluten intolerance associated with changes in eating behaviorin many countries, changes in the technology of growing and processing crops, new culinary technologies. Until recently, celiac disease, dermatitis herpetiformis and wheat allergy were the only known disease with a proven role of gluten in their pathogenesis. Non-celiac gluten sensitivity (NCGS) - a new syndrome of intolerance to gluten. This pathology can be suspected in patients with persistent intestinal and extra-intestinal symptoms clearly associated with the intake of foods containing gluten, the absence of serological markers of celiac disease or suspected allergy to wheat. The paper presents the current data on the epidemiology, etiology and pathogenesis, clinical features and diagnosis NCGS.

scholarly journals The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Zebrowska Agnieszka ◽  
Erkiert-Polguj Anna ◽  
Wagrowska-Danilewicz Malgorzata ◽  
Danilewicz Marian ◽  
Sysa-Jedrzejowska Anna ◽  
...  
Keyword(s):  
Fas Ligand ◽  
Dermatitis Herpetiformis ◽  
Single Cells ◽  
Skin Lesions ◽  
Control Group ◽  
Trail Expression ◽  
Skin Biopsies ◽  
And Control ◽  
Perilesional Skin

The role of the process of apoptosis is investigated in the pathogenesis of many autoimmune diseases; however at present, there is not much information about its role in dermatitis herpetiformis. Skin biopsies were taken from 18 DH patients and from 10 healthy subjects. The localization and expression of Bax, Fas, FasL, TRAIL, TRAIL-R in skin lesions, and perilesional skin were studied by immunohistochemistry. Expression of Bax, Fas, and Fas ligand was detected in the keratinocytes in skin biopsies from DH patients. Expression of TRAIL and TRAIL receptor was confirmed in epidermis, infiltration cells, and some fibroblasts. The expression of examined molecules in biopsies from healthy people was observed only in single cells. There were statistically significant differences between lesional, perilesional, and healthy skin of control group in Bax expression analysis and between lesional skin and control group in Fas, FasL, and TRAIL expression. There were statistically significant differences between control group and perilesional skin in Bax and FasL expression. Our results show that selected proapoptotic molecules may take part in pathogenesis of dermatitis herpetiformis, but the role of apoptosis in this process is not clear.

Role of Elemental Diet in Dermatitis herpetiformis

2015 ◽  
pp. 176-179 ◽  
Author(s):  
Jan B. van der Meer ◽  
Nico Zeedijk ◽  
Pieter C. van Voorst Vader ◽  
Marcelus C. J. M. de Jong
Keyword(s):  
Dermatitis Herpetiformis ◽  
Elemental Diet

scholarly journals Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis

2014 ◽  
Vol 19 (6) ◽  
pp. 837-843 ◽  
Author(s):  
Michael Kasperkiewicz ◽  
Stefan Tukaj ◽  
Anna-Julia Gembicki ◽  
Pálma Silló ◽  
Anna Görög ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Dermatitis Herpetiformis ◽  
Heat Shock Protein 60

scholarly journals The Long-Term Safety and Quality of Life Effects of Oats in Dermatitis Herpetiformis

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1060
Author(s):  
Anna Alakoski ◽  
Kaisa Hervonen ◽  
Eriika Mansikka ◽  
Timo Reunala ◽  
Katri Kaukinen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Coeliac Disease ◽  
Dermatitis Herpetiformis ◽  
Gastrointestinal Symptoms ◽  
Long Term Follow Up ◽  
Assess Quality

The treatment of choice for dermatitis herpetiformis (DH), a cutaneous manifestation of coeliac disease, is a life-long gluten-free diet (GFD). In a GFD, wheat, rye and barley should be strictly avoided, but the role of oats is more controversial. This study aimed to investigate the safety and long-term quality of life and health effects of oat consumption in 312 long-term treated DH patients. Baseline data were gathered from patient records and follow-up data from questionnaires or interviews, and validated questionnaires were used to assess quality of life. We found that altogether 256 patients (82%) were consuming oats as part of their GFD at the follow-up. Long-term follow-up data showed that there were no differences in the presence of long-term illnesses, coeliac disease complications or the usage of medication between those consuming and not consuming oats. However, oat consumers had a better quality of life and reported ongoing gastrointestinal symptoms less frequently (4% vs 19%, p = 0.004) at the follow-up than those not consuming oats. The study established that oats are safe for DH patients and in the long-term seem to improve the quality of life of DH patients.

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