9. Pathophysiology and Pharmacology of the Mucociliary System

AbstractTopical nasal phenylpropanolamine in a 2.5 per cent solution (PPA) was used in an evaluation of the possible development of tachyphylaxis and of possible effects on the mucociliary system after one week of treatment in healthy humans. The tendency of PPA to produce tachyphylaxis was evaluated by rhi-nomanometrie measurements of nasal airway resistance after repeated dose-response provocations. The mucociliary transport time was tested with the saccharine-dye test. No reduced dose-response effect or change in mucociliary transport time was found with PPA, thus indicating that one week of treatment does not contribute to such adverse effects.

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A new tuning fork with different vibration frequencies as an aid to bronchopulmonary hygiene physiotherapy

Multidisciplinary Respiratory Medicine ◽

10.4081/mrm.2014.376 ◽

2014 ◽

Vol 9 ◽

Author(s):

José Roberto De Alcântara ◽

Roberta Munhoz Manzano ◽

Maicon Gabriel Gonçalves ◽

Rodrigo Leonel Dos Santos ◽

Daniel Donaire Albino ◽

...

Keyword(s):

Tuning Fork ◽

Scientific Literature ◽

Fork Length ◽

Main Function ◽

Vibration Frequencies ◽

Fixed Frequency ◽

Digital Oscilloscope ◽

Mucociliary System ◽

Tuning Forks ◽

Different Dimensions

Background: The main function of the mucociliary system is the removal of particles or substances that are potentially harmful to the respiratory tract. The tuning fork therapeutic for the purpose of bronchial hygiene has still not been described in the literature. The optimal vibration frequency to mobilize secretions is widely debated and varies between 3 and 25 Hz. It is expected that a tuning fork is able to generate vibrations in the thorax, facilitating bronchial hygiene. The aim of the present study is to develop tuning forks with different frequencies, for use in bronchopulmonary hygiene therapy. Methods: The first tuning fork was made with a fixed frequency of 25 Hz and it was recorded in the Brazilian institution of patent registration. This device generated a frequency of 25 Hz and had a weight of 521 g, with dimensions of 600 mm in total length. The device is characterized by a bottom end containing a transducer with a diameter of 62 mm and a thickness of 5/16 mm (8''), a rod removable 148 mm, fork length of 362 mm and an extension at the upper end of sinuous shape bilaterally.The tuning forks must be applied at an angle of 90° directly on the chest wall of the patient after pulmonary auscultation for location of secretions. The tuning fork is activated by squeezing the tips of the extensions together and releasing them in a sudden movement. Results: This study shows the result of the development of others three tuning forks of different dimensions to generate different frequencies. Each equipment reaches a fixed frequency preset of 12, 15 and 20 Hz measured by digital oscilloscope. Conclusions: The tuning fork models developed in this study generated different frequencies proposed by the scientific literature as effective in the mobilization of pulmonary secretions.

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MOTION ACTIVITY OF AIRWAY CILIATED EPITHELIUM IN PATIENTS WITH ASTHMA

Bulletin physiology and pathology of respiration ◽

10.12737/23249 ◽

2016 ◽

Vol 1 (62) ◽

pp. 40-46

Author(s):

Михаил Луценко ◽

Mikhail Lutsenko

Keyword(s):

Inflammatory Process ◽

Mucociliary Clearance ◽

Severe Form ◽

Basal Bodies ◽

Ciliated Epithelium ◽

Epithelial Layer ◽

Bronchial Mucosa ◽

Ciliated Cells ◽

Motion Activity ◽

Mucociliary System

At asthma in bronchial mucous tunic as a result of chronic inflammatory process the working of mucociliary system is disturbed and there is restructuring of epithelial layer. The number of ciliary cells at the severe form of asthma decreases till 70%. The reason of restructuring of ciliated epithelium is the accumulation of a big number of fatty acids peroxides in the mucous tunic. Under their influence there is a decrease of activity of succinate dehydrogenase and ATP in the basal bodies of ciliary cells. Under the severe form of asthma there is a suppression of activity of mucociliary clearance as a result of destruction of a big number of bronchial mucosa ciliated cells.

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