Calcium Intake and Risk of Colorectal Cancer

2015 ◽  
pp. 177-187 ◽  
Author(s):  
R. J. Alder ◽  
G. McKeown-Eyssen
Keyword(s):  
Colorectal Cancer ◽  
Calcium Intake

scholarly journals Colorectal cancer, sun exposure and dietary vitamin D and calcium intake in the MCC-Spain study

2018 ◽  
Vol 121 ◽  
pp. 428-434 ◽  
Author(s):  
Xavier Vallès ◽  
M. Henar Alonso ◽  
Juan Francisco López-Caleya ◽  
Virginia Díez-Obrero ◽  
Trinidad Dierssen-Sotos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Calcium Intake ◽  
Sun Exposure ◽  
Dietary Vitamin ◽  
Dietary Vitamin D

scholarly journals Dietary calcium intake and the risk of colorectal cancer: a case control study

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Changwoo Han ◽  
Aesun Shin ◽  
Jeonghee Lee ◽  
Jeeyoo Lee ◽  
Ji Won Park ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Calcium Intake ◽  
Case Control Study ◽  
Dietary Calcium ◽  
Case Control ◽  
Dietary Calcium Intake ◽  
Control Study

scholarly journals Calcium intake and risk of colorectal cancer in the Multiethnic Cohort Study

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Song Yi Park ◽  
Suzanne P. Murphy ◽  
Lynne R. Wilkens ◽  
Abraham M. Y. Nomura ◽  
Laurence N. Kolonel
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Calcium Intake ◽  
Multiethnic Cohort

scholarly journals Vitamin D, magnesium, calcium, and their interaction in relation to colorectal cancer recurrence and all-cause mortality

2020 ◽  
Vol 111 (5) ◽  
pp. 1007-1017
Author(s):  
Evertine Wesselink ◽  
Dieuwertje E Kok ◽  
Martijn J L Bours ◽  
Johannes H W de Wilt ◽  
Harm van Baar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Calcium Intake ◽  
Cancer Recurrence ◽  
Underlying Mechanism ◽  
Inverse Association ◽  
Vitamin D Metabolism ◽  
Magnesium Intake ◽  
All Cause Mortality ◽  
Sufficient Vitamin

ABSTRACT Background Higher concentrations of 25-hydroxyvitamin D3 [25(OH)D3] at diagnosis are associated with a lower mortality risk in colorectal cancer (CRC) patients. However, magnesium and calcium are important in vitamin D metabolism. Objectives We aimed to investigate 25(OH)D3, magnesium, or calcium and their interaction among patients with CRC in relation to recurrence and all-cause mortality. Methods The study population included 1169 newly diagnosed stage I–III CRC patients from 2 prospective cohorts. Associations between 25(OH)D3 concentrations, magnesium or calcium intake through diet and/or supplements at diagnosis, and recurrence and all-cause mortality were evaluated using multivariable Cox proportional hazard models. The interaction between 25(OH)D3 and magnesium or calcium was assessed by investigating 1) joint compared with separate effects, using a single reference category; and 2) the effect estimates of 1 factor across strata of another. Results Serum 25(OH)D3, calcium, and magnesium, alone and their interactions, were not associated with recurrence. Serum 25(OH)D3 concentrations seemed to be associated with all-cause mortality. An inverse association between magnesium intake (HRQ3 vs. Q1: 0.55; 95% CI: 0.32, 0.95 and HRQ4 vs. Q1: 0.65; 95% CI: 0.35, 1.21), but not calcium intake, and all-cause mortality was observed. When investigating the interaction between 25(OH)D3 and magnesium, we observed the lowest risk of all-cause mortality in patients with sufficient vitamin D concentrations (≥50 nmol/L) and a high magnesium intake (median split) (HR: 0.53; 95% CI: 0.31, 0.89) compared with patients who were vitamin D deficient (<50 nmol/L) and had a low magnesium intake. No interactions between calcium and vitamin D in relation to all-cause mortality were observed. Conclusions Our findings suggest that the presence of an adequate status of 25(OH)D3 in combination with an adequate magnesium intake is essential in lowering the risk of mortality in CRC patients, yet the underlying mechanism should be studied. In addition, diet and lifestyle intervention studies are needed to confirm our findings. The COLON study was registered at clinicaltrials.gov as NCT03191110. The EnCoRe study was registered at trialregister.nl as NTR7099.

Calcium, dairy and colon cancer - the latest

2007 ◽  
Vol 271 ◽  
pp. 1-3 ◽  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Vitamin D ◽  
Observational Data ◽  
Calcium Intake ◽  
Vitamin D Status ◽  
Intestinal Polyp ◽  
Polyp Recurrence ◽  
General Populations

In a nutshellThere is very strong in vitro and observational data showing a protective association between dairy and calcium intake and colorectal cancer. Vitamin D status and possibly genetics also seem to influence this link.A few RCTs suggest calcium + vit. D supplements help prevent intestinal polyp recurrence. We lack RCT evidence that this in turn stops colon cancer, and if so it is more likely to work in at-risk rather than general populations.

scholarly journals Calcium intake and colorectal cancer risk: Dose-response meta-analysis of prospective observational studies

2014 ◽  
Vol 135 (8) ◽  
pp. 1940-1948 ◽  
Author(s):  
NaNa Keum ◽  
Dagfinn Aune ◽  
Darren C. Greenwood ◽  
Woong Ju ◽  
Edward L. Giovannucci
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Calcium Intake ◽  
Observational Studies ◽  
Meta Analysis ◽  
Colorectal Cancer Risk

scholarly journals Calcium Intake and Survival after Colorectal Cancer Diagnosis

2018 ◽  
Vol 25 (6) ◽  
pp. 1980-1988 ◽  
Author(s):  
Wanshui Yang ◽  
Yanan Ma ◽  
Stephanie Smith-Warner ◽  
Mingyang Song ◽  
Kana Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Calcium Intake
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