scholarly journals Calcium intake and colorectal cancer risk: Dose-response meta-analysis of prospective observational studies

2014 ◽  
Vol 135 (8) ◽  
pp. 1940-1948 ◽  
Author(s):  
NaNa Keum ◽  
Dagfinn Aune ◽  
Darren C. Greenwood ◽  
Woong Ju ◽  
Edward L. Giovannucci
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Calcium Intake ◽  
Observational Studies ◽  
Meta Analysis ◽  
Colorectal Cancer Risk

scholarly journals Phyto-oestrogens and colorectal cancer risk: a systematic review and dose–response meta-analysis of observational studies

2016 ◽  
Vol 116 (12) ◽  
pp. 2115-2128 ◽  
Author(s):  
Ruijingfang Jiang ◽  
Akke Botma ◽  
Anja Rudolph ◽  
Anika Hüsing ◽  
Jenny Chang-Claude
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Colorectal Cancer Risk ◽  
Current Evidence ◽  
Cochrane Library ◽  
Reduced Risk

AbstractEpidemiological studies suggest that soya consumption as a source of phyto-oestrogens and isoflavones may be associated with a reduced risk of colorectal cancer. However, findings have not yet been synthesised for all groups of phyto-oestrogens. A meta-analysis was conducted to quantify the association between phyto-oestrogens and colorectal cancer risk. Relevant observational studies published up to June 2016 were identified by searching MEDLINE, EMBASE and Cochrane Library databases. Study-specific relative risks (RR) were pooled in both categorical and dose–response meta-analyses. Out of seventeen identified studies, sixteen were included in the meta-analysis. Comparing the highest with the lowest intake category, inverse associations for phyto-oestrogens overall and by subgroup were observed but were statistically significant in case–controls studies and not in cohort studies. The pooled RR in case–control studies were 0·76 (95 % CI 0·69, 0·84), 0·77 (95 % CI 0·69, 0·85) and 0·70 (95 % CI 0·56, 0·89) for phyto-oestrogens, isoflavones and lignans, respectively, whereas the corresponding pooled RR were 0·95 (95 % CI 0·85, 1·06), 0·94 (95 % CI 0·84, 1·05) and 1·00 (95 % CI 0·64, 1·57) in cohort studies. Dose–response analysis yielded an 8 % reduced risk of colorectal neoplasms for every 20 mg/d increase in isoflavones intake in Asians (pooled RR 0·92; 95 % CI 0·86, 0·97). A non-linear inverse association with colorectal cancer risk was found for lignans intake, but no association for circulating enterolactone concentrations was observed. Thus, study heterogeneity precludes a rigorous conclusion regarding an effect of high exposure to isoflavones on risk of colorectal cancer. Current evidence for an association with lignans exposure is limited. Further prospective studies, particularly evaluating lignans, are warranted to clarify the association between different phyto-oestrogens and colorectal cancer risk.

scholarly journals Association Between Blood Circulating Vitamin D and Colorectal Cancer Risk in Asian Countries: A Systematic Review and Dose-Response Meta-analysis

2019 ◽  
Author(s):  
Lin Zhang ◽  
Huachun Zou ◽  
Yang Zhao ◽  
Chunlei Hu ◽  
Adejare (Jay) Atanda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Asian Population ◽  
Colorectal Cancer Risk ◽  
Asian Countries ◽  
Case Control Studies ◽  
Vitamin D Levels

ABSTRACTObjectivesTo assess the association between blood circulating Vitamin D levels and colorectal cancer risk in the Asian population.DesignThis is a systematic review and dose-response meta-analysis of observational studies that investigated the relationship between blood circulating Vitamin D levels and colorectal cancer risk in the Asian population.Data SourcesRelevant studies were identified through a literature search in MEDLINE, EMBASE, and Web of Science from January 1980 to 31 January 2019. Eligibility criteria: original studies published in peer-reviewed journals investigating the association between blood circulating Vitamin D levels and the risk of colorectal cancer and/or adenoma in Asian countries.Data extraction and synthesisTwo authors independently extracted data and assessed the quality of included studies. Study-specific ORs were pooled using a random-effects model. A dose-response meta-analysis was performed with generalized least squares regression. We applied the Newcastle-Ottawa Scale quality assessment to evaluate the quality of the selected studies.ResultsThe eight included studies encompassed a total of 2,916 cases and 6,678 controls. The pooled ORs of colorectal cancer for the highest versus lowest categories of blood circulating Vitamin D levels was 0.75 [95% CI, 0.58-0.97] up to 36.5 ng/mL in the Asian population. There was heterogeneity among the studies (I2=53.9%, Pheterogeneity=0.034). The dose-response meta-analysis indicated a significant linear relationship (Pnon-linearity=0.11). An increment of 16 ng/mL in blood circulating Vitamin D level corresponded to an OR of 0.79 [95% CI, 0.64-0.97].ConclusionsThe results of this meta□analysis indicate that blood circulating Vitamin D level is associated with decreased risk of colorectal cancer in Asian countries. The dose-response meta-analysis shows that the strength of this association among the Asian population is similar to that among the Western population. Our study suggests that the Asian population should improve nutritional status and maintain a higher level of blood circulating Vitamin D.Strengths and limitations of this studyOur study seeks to extend previous work by including a number of new studies and by distinguishing the Asian population explicitly.The number of included studies is not sufficient to provide a robust estimate, so the results should be interpreted in the context of the limitations of the available data.Heterogeneous definitions of blood circulating Vitamin D categories were used across studies. The variability in definitions could limit comparability between studies.Our study included seven case-control studies; the study design implies that the measurement of blood circulating Vitamin D is measured in individuals already diagnosed with colorectal cancer. Results from case-control studies need to be interpreted cautiously because of the potential for reverse causation.Time of blood sampling in relation to outcome ascertainment also varied among studies. Such cross-sectional measurements may not accurately reflect an individual’s Vitamin D status across time.

scholarly journals Alcohol drinking and colorectal cancer risk: an overall and dose–response meta-analysis of published studies

2011 ◽  
Vol 22 (9) ◽  
pp. 1958-1972 ◽  
Author(s):  
V. Fedirko ◽  
I. Tramacere ◽  
V. Bagnardi ◽  
M. Rota ◽  
L. Scotti ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Alcohol Drinking ◽  
Meta Analysis ◽  
Colorectal Cancer Risk

scholarly journals Alcohol intake and colorectal cancer risk: A dose–response meta-analysis of published cohort studies

2006 ◽  
Vol 120 (3) ◽  
pp. 664-671 ◽  
Author(s):  
Aurélie Moskal ◽  
Teresa Norat ◽  
Pietro Ferrari ◽  
Elio Riboli
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Dose Response ◽  
Alcohol Intake ◽  
Meta Analysis ◽  
Colorectal Cancer Risk

scholarly journals Association between blood circulating vitamin D and colorectal cancer risk in Asian countries: a systematic review and dose-response meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. e030513 ◽  
Author(s):  
Lin Zhang ◽  
Huachun Zou ◽  
Yang Zhao ◽  
Chunlei Hu ◽  
Adejare Atanda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Asian Population ◽  
Colorectal Cancer Risk ◽  
Asian Countries ◽  
Vitamin D Levels

ObjectivesTo assess the association between blood circulating vitamin D levels and colorectal cancer risk in the Asian population.DesignThis is a systematic review and dose-response meta-analysis of observational studies that investigated the relationship between blood circulating vitamin D levels and colorectal cancer risk in the Asian population.Data sourcesRelevant studies were identified through a literature search in Medline, Embase and Web of Science from 1st January 1980 to 31st January 2019. Eligibility criteria: original studies published in peer-reviewed journals investigating the association between blood circulating vitamin D levels and the risk of colorectal cancer and/or adenoma in Asian countries.Data extraction and synthesisTwo authors independently extracted data and assessed the quality of included studies. Study-specific ORs were pooled using a random-effects model. A dose-response meta-analysis was performed with generalised least squares regression. We applied the Newcastle-Ottawa Scale quality assessment to evaluate the quality of the selected studies.ResultsThe eight included studies encompassed a total of 2916 cases and 6678 controls. The pooled ORs of colorectal cancer for the highest versus lowest categories of blood circulating vitamin D levels was 0.75 (95% CI 0.58 to 0.97) up to 36.5 ng/mL in the Asian population. There was heterogeneity among the studies (I2=53.9%,Pheterogeneity=0.034). The dose-response meta-analysis indicated a significant linear relationship (Pnon-linearity=0.11). An increment of 16 ng/mL in blood circulating vitamin D level corresponded to an OR of 0.79 (95% CI 0.64 to 0.97).ConclusionsThe results of this meta‐analysis indicate that blood circulating vitamin D level is associated with decreased risk of colorectal cancer in Asian countries. The dose-response meta-analysis shows that the strength of this association among the Asian population is similar to that among the Western population. Our study suggests that the Asian population should improve nutritional status and maintain a higher level of blood circulating vitamin D.

scholarly journals Renin–angiotensin system inhibitor use and colorectal cancer risk and mortality: A dose–response meta analysis

2020 ◽  
Vol 21 (3) ◽  
pp. 147032031989564 ◽  
Author(s):  
Xia Chen ◽  
Chang-hong Yi ◽  
Kuang-guan Ya
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Renin Angiotensin System ◽  
Colorectal Cancer Risk ◽  
Morbidity And Mortality ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Cancer Morbidity

Objective: This study was undertaken to determine whether use of the renin–angiotensin system (RAS) inhibitors would increase colorectal cancer morbidity and mortality. Methods: Databases were electronically searched to collect data of RAS use and colorectal cancer morbidity and mortality from inception to October 2018. Stata 12.0 software was used to perform a meta-analysis. Results: A total of 16 publications involving 2,847,597 participants were included. RAS inhibitor use was related to colorectal cancer risk (relative risk (RR): 0.86; 95% confidence interval (CI): 0.78–0.93) and mortality (RR: 0.80; 95% CI: 0.66–0.98) decrement. Subgroup analysis showed angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) (RR: 0.82; 95% CI: 0.69-0.96) or ARB (RR: 0.86; 95% CI: 0.73–0.98) or ACEI (RR: 0.81; 95% CI: 0.70–0.92) were related to colorectal cancer risk decrement. Furthermore, RAS inhibitor use was related to colorectal cancer risk decrement in Caucasians (RR: 0.88; 95% CI: 0.80–0.96) and Asians (RR: 0.72; 95% CI: 0.61–0.85). Additionally, dose–response showed that per one year duration of RAS inhibitor use incremental increase was related to 6% colorectal cancer risk decrement (RR: 0.94; 95% CI: 0.90–0.97). Conclusion: According to the evidence, RAS inhibitor use was associated with colorectal cancer risk and mortality decrement.

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