Interaction of Timnodonic Acid with Two Other PG Precursors in Rabbit Tissue

2015 ◽  
pp. 79-83
Author(s):  
H. Juan ◽  
W. Sametz
Keyword(s):  
Rabbit Tissue

Plasma Cells in the Reaction against Rabbit Tissue Homografts

Nature ◽  
1949 ◽  
Vol 163 (4133) ◽  
pp. 98-99 ◽  
Author(s):  
D. A. DARCY
Keyword(s):  
Plasma Cells ◽  
Rabbit Tissue

Growth and cytopathic effects of rubella virus in primary rabbit tissue culture

1965 ◽  
Vol 16 (1-5) ◽  
pp. 415-418 ◽  
Author(s):  
K. McCarthy ◽  
C. H. Taylor-Robinson
Keyword(s):  
Tissue Culture ◽  
Rubella Virus ◽  
Cytopathic Effects ◽  
Rabbit Tissue ◽  
Primary Rabbit

scholarly journals Purification of Treponema pallidum from Infected Rabbit Tissue: Resolution into Two Treponemal Populations

1974 ◽  
Vol 10 (5) ◽  
pp. 1062-1067 ◽  
Author(s):  
Joel B. Baseman ◽  
Jean C. Nichols ◽  
J. William Rumpp ◽  
Nancy S. Hayes
Keyword(s):  
Treponema Pallidum ◽  
Infected Rabbit ◽  
Rabbit Tissue

The calibration of rabbit tissue thromboplastins: experience of the Dutch Reference Laboratory for anticoagulant control

1986 ◽  
Vol 14 (4) ◽  
pp. 305-317 ◽  
Author(s):  
A.M.H.P. van den Besselaar ◽  
J. Hermans ◽  
E.A. van der Velde ◽  
E.Bussemaker-Verduyn den Boer ◽  
L.P. van Halem-Visser ◽  
...  
Keyword(s):  
Reference Laboratory ◽  
Rabbit Tissue

scholarly journals Selection of Resistant Streptococcus pneumoniae during Penicillin Treatment In Vitro and in Three Animal Models

2003 ◽  
Vol 47 (8) ◽  
pp. 2499-2506 ◽  
Author(s):  
Jenny Dahl Knudsen ◽  
Inga Odenholt ◽  
Helga Erlendsdottir ◽  
Magnus Gottfredsson ◽  
Otto Cars ◽  
...  
Keyword(s):  
Animal Models ◽  
Mixed Culture ◽  
Observation Time ◽  
Treatment Regimens ◽  
Rabbit Tissue ◽  
Drug Concentrations ◽  
Wide Range ◽  
Different Strains ◽  
Selection Of

ABSTRACT Pharmacokinetic (PK) and pharmacodynamic (PD) properties for the selection of resistant pneumococci were studied by using three strains of the same serotype (6B) for mixed-culture infection in time-kill experiments in vitro and in three different animal models, the mouse peritonitis, the mouse thigh, and the rabbit tissue cage models. Treatment regimens with penicillin were designed to give a wide range of T>MICs, the amounts of time for which the drug concentrations in serum were above the MIC. The mixed culture of the three pneumococcal strains, 107 CFU of strain A (MIC of penicillin, 0.016 μg/ml; erythromycin resistant)/ml, 106 CFU of strain B (MIC of penicillin, 0.25 μg/ml)/ml, and 105 CFU of strain C (MIC of penicillin, 4 μg/ml)/ml, was used in the two mouse models, and a mixture of 105 CFU of strain A/ml, 104 CFU of strain B/ml, and 103 CFU of strain C/ml was used in the rabbit tissue cage model. During the different treatment regimens, the differences in numbers of CFU between treated and control animals were calculated to measure the efficacies of the regimens. Selective media with erythromycin or different penicillin concentrations were used to quantify the strains separately. The efficacies of penicillin in vitro were similar when individual strains or mixed cultures were studied. The eradication of the bacteria, independent of the susceptibility of the strain or strains or the presence of the strains in a mixture or on their own, followed the well-known PK and PD rules for treatment with β-lactams: a maximum efficacy was seen when the T>MIC was >40 to 50% of the observation time and the ratio of the maximum concentration of the drug in serum to the MIC was >10. It was possible in all three models to select for the less-susceptible strains by using insufficient treatments. In the rabbit tissue cage model, a regrowth of pneumococci was observed; in the mouse thigh model, the ratio between the different strains changed in favor of the less-susceptible strains; and in the mouse peritonitis model, the susceptible strain disappeared and was overgrown by the less-susceptible strains. These findings with the experimental infection models confirm the importance of eradicating all the bacteria taking part in the infectious process in order to avoid selection of resistant clones.

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