Steady State Serum and Synovial Fluid Concentrations of Tolmetin and Its Metabolite in Arthritic Patients

2015 ◽  
pp. 177-184 ◽  
Author(s):  
Ravi K. Desiraju ◽  
Ramchandra K. Nayak ◽  
Daniel E. Furst ◽  
Harold E. Paulus
Keyword(s):  
Steady State ◽  
Synovial Fluid ◽  
Steady State Serum

Effect of naproxen on the steady-state serum concentration and anticoagulant activity of warfarin

1979 ◽  
Vol 25 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Adesh Jain ◽  
F. Gilbert McMahon ◽  
John T. Slattery ◽  
Gerhard Levy
Keyword(s):  
Steady State ◽  
Serum Concentration ◽  
Anticoagulant Activity ◽  
Steady State Serum

scholarly journals Steady-State Serum IgG Trough Levels Are Adequate for Pharmacokinetic Assessment in Patients with Immunodeficiencies Receiving Subcutaneous Immune Globulin

2021 ◽  
Author(s):  
Zhaoyang Li ◽  
Barbara McCoy ◽  
Werner Engl ◽  
Leman Yel
Keyword(s):  
Steady State ◽  
Trough Level ◽  
Geometric Mean ◽  
Time Profiles ◽  
Level Measurement ◽  
Serum Igg ◽  
Pharmacokinetic Assessment ◽  
Steady State Serum ◽  
Serum Igg Levels ◽  
Trough Levels

AbstractPatients with primary immunodeficiency diseases often require lifelong immunoglobulin (IG) therapy. Most clinical trials investigating IG therapies characterize serum immunoglobulin G (IgG) pharmacokinetic (PK) profiles by serially assessing serum IgG levels. This retrospective analysis evaluated whether steady-state serum IgG trough level measurement alone is adequate for PK assessment. Based on individual patient serum IgG trough levels from two pivotal trials (phase 2/3 European [NCT01412385] and North American [NCT01218438]) of weekly 20% subcutaneous IG (SCIG; Cuvitru, Ig20Gly), trough level-predicted IgG AUC (AUCτ,tp) were calculated and compared with the reported AUC calculated from serum IgG concentration-time profiles (AUCτ). In both studies, mean AUCτ,tp values for Ig20Gly were essentially equivalent to AUCτ with point estimates of geometric mean ratio (GMR) of AUCτ,tp/AUCτ near 1.0 and 90% CIs within 0.80–1.25. In contrast, for IVIG, 10%, mean AUCτ,tp values were lower than AUCτ by >20%, (GMR [90% CI]: 0.74 [0.70–0.78] and 0.77 [0.73–0.81] for the two studies, respectively). Mean AUCτ,tp values calculated for 4 other SCIG products (based on mean IgG trough levels reported in the literature/labels) were also essentially equivalent to the reported AUCτ (differences <10% for all except HyQvia, a facilitated SCIG product), while differences for IVIG products were >20%. In conclusion, steady-state serum IgG levels following weekly SCIG remain stable, allowing for reliable prediction of AUC over the dosing interval using trough IgG levels. These findings indicate that measuring steady-state serum IgG trough levels alone may be adequate for PK assessment of weekly SCIG.

Relationship of steady-state serum concentrations of amiodarone and desethylamiodarone to therapeutic efficacy and adverse effects

1987 ◽  
Vol 82 (6) ◽  
pp. 1102-1108 ◽  
Author(s):  
Ruth Falik ◽  
Belinda T. Flores ◽  
Leslie Shaw ◽  
Gene A. Gibson ◽  
Mark E. Josephson ◽  
...  
Keyword(s):  
Steady State ◽  
Adverse Effects ◽  
Therapeutic Efficacy ◽  
Serum Concentrations ◽  
Steady State Serum ◽  
Relationship Of

Cimetidine's Effect on Steady-State Serum Nortriptyline Concentrations

1983 ◽  
Vol 17 (12) ◽  
pp. 904-905 ◽  
Author(s):  
Del D. Miller ◽  
John B. Sawyer ◽  
J. Patrick Duffy
Keyword(s):  
Steady State ◽  
Black Male ◽  
Concomitant Administration ◽  
Steady State Serum ◽  
Clinical Consequences

A cimetidine-nortriptyline interaction in a 52-year-old black male is reported. After concomitant administration of cimetidine and nortriptyline for two weeks, steady-state nortriptyline concentrations fell 42 percent when cimetidine was discontinued. Later, during rechallenge with cimetidine, serum nortriptyline concentrations increased significantly, but subsequently fell again when cimetidine was discontinued. The possible clinical consequences of this interaction are discussed.

Carbamazepine-Isoniazid Interaction

PEDIATRICS ◽  
1983 ◽  
Vol 71 (1) ◽  
pp. 139-139
Author(s):  
J. M. WRIGHT
Keyword(s):  
Case Report ◽  
Steady State ◽  
Significant Interaction ◽  
Similar Case ◽  
Drug Regimen ◽  
Acetylator Phenotype ◽  
Serum Concentrations ◽  
Slow Acetylator ◽  
Steady State Serum ◽  
Clinically Significant

To the Editor.— The case report of carbamazepine intoxication secondary to isoniazid administration recently described in this journal1 is a clinically significant interaction. I have previously presented2 a similar case in which a patient receiving carbamazepine, valproate, and nitrazepam developed severe carbamazepine intoxication when isoniazid was added to the drug regimen. The patient was determined to have inherited the slow acetylator phenotype. On careful rechallenge, 300 mg of isoniazid increased carbamazepine steady-state serum concentrations by 85% and decreased carbamazepine clearance by 45%.

The Utility of a Single-Point Dosing Protocol for Predicting Steady-State Lithium Levels

1986 ◽  
Vol 148 (4) ◽  
pp. 401-405 ◽  
Author(s):  
Paul J. Perry ◽  
Bruce Alexander ◽  
Randall A. Prince ◽  
Frederick J. Dunner
Keyword(s):  
Steady State ◽  
Affective Disorder ◽  
Single Point ◽  
Test Dose ◽  
Point Method ◽  
Lithium Level ◽  
Clinical Interpretation ◽  
Serum Lithium Level ◽  
Steady State Serum

Two methods for predicting steady-state serum lithium level were compared prospectively in in-patients suffering from affective disorder. A single-point prospective administration model that required a single 24-hour serum lithium level, following a test dose produced statistically similar predictions of the observed steady-state lithium levels as did a model that required 12- and 36-hour levels. However, the latter two-point method produced significantly more accurate predictions from clinical interpretation. Although the two-point approach is preferable, the single-point method is clinically acceptable if its limitations of accuracy are taken into consideration.

scholarly journals Pharmacokinetics of continuous intravenous and subcutaneous infusions of cytosine arabinoside

Blood ◽  
1982 ◽  
Vol 59 (6) ◽  
pp. 1351-1353 ◽  
Author(s):  
HJ Weinstein ◽  
TW Griffin ◽  
J Feeney ◽  
HJ Cohen ◽  
RD Propper ◽  
...  
Keyword(s):  
Steady State ◽  
Cytosine Arabinoside ◽  
Routes Of Administration ◽  
Intravenous Infusions ◽  
Steady State Serum

Abstract The pharmacokinetics of continuous subcutaneous cytosine arabinoside (ara-C) infusions were compared with continuous intravenous infusions. Steady-state serum ara-C levels and myelosuppression were similar with both routes of administration. CSF/serum ara-C ratios ranged from 0.14 to 0.91 (mean, 0.58). Continuous subcutaneous ara-C infusions were a convenient and reliable alternative to intravenous infusions.

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