The Utility of a Single-Point Dosing Protocol for Predicting Steady-State Lithium Levels

1986 ◽  
Vol 148 (4) ◽  
pp. 401-405 ◽  
Author(s):  
Paul J. Perry ◽  
Bruce Alexander ◽  
Randall A. Prince ◽  
Frederick J. Dunner
Keyword(s):  
Steady State ◽  
Affective Disorder ◽  
Single Point ◽  
Test Dose ◽  
Point Method ◽  
Lithium Level ◽  
Clinical Interpretation ◽  
Serum Lithium Level ◽  
Steady State Serum

Two methods for predicting steady-state serum lithium level were compared prospectively in in-patients suffering from affective disorder. A single-point prospective administration model that required a single 24-hour serum lithium level, following a test dose produced statistically similar predictions of the observed steady-state lithium levels as did a model that required 12- and 36-hour levels. However, the latter two-point method produced significantly more accurate predictions from clinical interpretation. Although the two-point approach is preferable, the single-point method is clinically acceptable if its limitations of accuracy are taken into consideration.

Comparison of Pharmacokinetic Procedures for Dosing Lithium Based on Analysis of Prediction Error

1988 ◽  
Vol 22 (3) ◽  
pp. 227-231 ◽  
Author(s):  
Jerry L. Browne ◽  
Rajesh A. Patel ◽  
Camerson S. Huffman ◽  
Betty K. Hussey
Keyword(s):  
Steady State ◽  
Prediction Error ◽  
Lithium Concentration ◽  
Single Point ◽  
Lithium Carbonate ◽  
Point Method ◽  
Sign Test ◽  
Multiple Point ◽  
Prediction Errors ◽  
Dosing Method

Five pharmacokinetic methods for estimating maintenance dosage requirements of lithium carbonate were compared retrospectively in 20 inpatients with acute bipolar illness. Specific pharmacokinetic methods tested included the method of Cooper, the multiple-point method of Perry, the single-point method of Perry, the method of Zetin, and the method of Pepin. Data analysis was based on evaluation of prediction error or the difference between the predicted steady-state lithium concentration and the measured steady-state lithium concentration at equivalent daily doses. Each dosing method was assessed in regard to accuracy and bias of predicted steady-state serum lithium concentrations. Bias was assessed by comparison of the median value of the prediction error with zero. The dosing recommendation based on the Cooper nomogram resulted in a significant positive bias (p ≤ 0.05). Intermethod accuracy was assessed by comparison of the absolute prediction errors of each dosing method. Significant differences in accuracy were observed between the method of Pepin when compared with the single-point method of Perry (p ≤ 0.05, k-sample sign test). All other comparisons were nonsignificant.

Effect of fasting during Ramadan on serum lithium level and mental state in bipolar affective disorder

2010 ◽  
Vol 25 (6) ◽  
pp. 323-327 ◽  
Author(s):  
Saeed Farooq ◽  
Zahid Nazar ◽  
Javed Akhter ◽  
Mohammad Irafn ◽  
Fazal Subhan ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Mental State ◽  
Bipolar Affective Disorder ◽  
Lithium Level ◽  
Serum Lithium Level

scholarly journals Delirium associated with olanzapine therapy in a patient with Bipolar Affective Disorder: A Case Report

2017 ◽  
Vol 4 (2) ◽  
pp. 30-32
Author(s):  
R. Shrestha ◽  
P.M. Singh ◽  
N. Joshi ◽  
G. Dhonju
Keyword(s):  
Case Report ◽  
Hospital Admission ◽  
Affective Disorder ◽  
Complete Resolution ◽  
Bipolar Affective Disorder ◽  
Lithium Level ◽  
Serum Lithium Level ◽  
Olanzapine Therapy

A patient of Bipolar Affective Disorder (BPAD) developed delirium after initiation and increment in the dosage of olanzapine. After hospital admission, we started olanzapine in combination with lithium. Olanzapine was gradually increased to 30 mg/day and lithium gradually increased to 1000 mg/day with serum lithium level at 0.85 mmol/L. After discontinuation of olanzapine, there was a complete resolution of delirium. We, hereby, report the case of delirium associated with olanzapine therapy.

What is the optimal serum lithium level in the long-term treatment of bipolar disorder? A review

2007 ◽  
Vol 40 (06) ◽  
Author(s):  
E Severus ◽  
N Kleindienst ◽  
F Seemüller ◽  
S Frangou ◽  
HJ Möller ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Term Treatment ◽  
Lithium Level ◽  
Serum Lithium Level ◽  
Long Term Treatment

Effect of naproxen on the steady-state serum concentration and anticoagulant activity of warfarin

1979 ◽  
Vol 25 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Adesh Jain ◽  
F. Gilbert McMahon ◽  
John T. Slattery ◽  
Gerhard Levy
Keyword(s):  
Steady State ◽  
Serum Concentration ◽  
Anticoagulant Activity ◽  
Steady State Serum
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