Nomographic estimation of time to reach steady-state serum concentration during phenytoin therapy

1980 ◽  
Vol 17 (1) ◽  
pp. 33-35 ◽  
Author(s):  
S. Vozeh ◽  
F. Follath
Keyword(s):  
Steady State ◽  
Serum Concentration ◽  
Steady State Serum ◽  
Estimation Of Time

Effect of naproxen on the steady-state serum concentration and anticoagulant activity of warfarin

1979 ◽  
Vol 25 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Adesh Jain ◽  
F. Gilbert McMahon ◽  
John T. Slattery ◽  
Gerhard Levy
Keyword(s):  
Steady State ◽  
Serum Concentration ◽  
Anticoagulant Activity ◽  
Steady State Serum

Thiopental Pharmacodynamics I. Defining the Pseudo–Steady-state Serum Concentration–EEG Effect Relationship

1992 ◽  
Vol 77 (2) ◽  
pp. 226-236 ◽  
Author(s):  
Michael Bührer ◽  
Pierre O. Maitre ◽  
Orlando R. Hung ◽  
William F. Ebling ◽  
Steven L. Shafer ◽  
...  
Keyword(s):  
Steady State ◽  
Serum Concentration ◽  
Effect Relationship ◽  
Steady State Serum

Evaluation of Three Methods for Determining Initial Vancomycin Doses

DICP ◽  
1989 ◽  
Vol 23 (2) ◽  
pp. 123-128 ◽  
Author(s):  
Bruce H. Ackerman
Keyword(s):  
Steady State ◽  
Serum Concentration ◽  
Pharmacokinetic Data ◽  
Serum Concentrations ◽  
Dose Selection ◽  
Open Model ◽  
Dosing Interval ◽  
Steady State Serum ◽  
Serum Vancomycin ◽  
Compartment Open Model

Dosing methods proposed by Matzke et al., Moellering et al., and Lake and Peterson were used to predict initial doses of vancomycin for serum concentration simulation using a two-compartment open model. Previously reported pharmacokinetic data from 25 of 28 patients were used to simulate steady-state serum vancomycin concentrations for doses derived from the three methods. The Matzke method failed to provide simulated one-hour postinfusion levels < 30 μg/mL in 48 percent and troughs > 5 μg/mL in more than 88 percent of the patients. The Moellering method succeeded in achieving this goal in 96 percent of the simulated one-hour levels, and in 72 percent of the troughs when a six-hour dosing interval was selected. For the 8 mg/kg Lake-Peterson doses, one-hour levels > 30 μg/mL occurred in 28 percent of the simulations, and for the 10 mg/kg doses this increased to 40 percent. The 8 mg/kg doses resulted in trough simulations < 5 μg/mL in 28 percent and the 10 mg/kg reduced this to only 20 percent. These simulations indicated that the Moellering nomogram with the six-hour dosing interval was the most successful method for initial dose selection, but early serum concentration monitoring and adjustment of initial empirical and nomogram-derived doses is necessary to assure safe and effective vancomycin serum concentrations.

Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics

Neurology ◽  
1988 ◽  
Vol 38 (4) ◽  
pp. 639-639 ◽  
Author(s):  
T. R. Browne ◽  
G. K. Szabo ◽  
J. Evans ◽  
B. A. Evans ◽  
D. J. Greenblatt ◽  
...  
Keyword(s):  
Steady State ◽  
Serum Concentration ◽  
Steady State Serum

Combined Effect of CYP2B6 Genotype and Other Candidate Genes on a Steady-State Serum Concentration of Methadone in Opioid Maintenance Treatment

2017 ◽  
Vol 39 (5) ◽  
pp. 550-555 ◽  
Author(s):  
Marianne K. Kringen ◽  
Fatemeh Chalabianloo ◽  
Jean-Paul Bernard ◽  
Jørgen G. Bramness ◽  
Espen Molden ◽  
...  
Keyword(s):  
Steady State ◽  
Serum Concentration ◽  
Candidate Genes ◽  
Maintenance Treatment ◽  
Combined Effect ◽  
Opioid Maintenance Treatment ◽  
Steady State Serum
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