Diagnostic Use of an Antiserum Made against Acute Lymphoid Leukaemia Associated Antigen

Author(s):  
G. Janossy ◽  
M. F. Greaves
The Lancet ◽  
1918 ◽  
Vol 191 (4945) ◽  
pp. 803
Author(s):  
JohnC. Tull

2018 ◽  
Vol 55 ◽  
pp. 96-103 ◽  
Author(s):  
A. Bonaventure ◽  
L. Orsi ◽  
J. Rudant ◽  
S. Goujon-Bellec ◽  
G. Leverger ◽  
...  

Author(s):  
G. Math� ◽  
P. Pouillart ◽  
L. Schwarzenberg ◽  
J. L. Amiel ◽  
M. Schneider ◽  
...  

2008 ◽  
Vol 24 (9) ◽  
pp. 603-610 ◽  
Author(s):  
Y Yang ◽  
XM Jin ◽  
CH Yan ◽  
Y Tian ◽  
JY Tang ◽  
...  

The 8-hydroxy-2′-deoxyguanosine (8-OHdG), an oxidized nucleoside of DNA, not only is a widely used biomarker for the measurement of endogenous oxidative DNA damage but might also be a risk factor for many diseases including cancer. Metal exposure may play an important role in oxidative DNA damage among children. However, few studies on urinary 8-OHdG and metals have been conducted in children with acute leukemia. In the present study, urinary Ni and 8-OHdG were examined in 116 children with acute leukaemia (94 acute lymphoid leukaemia [ALL] and 22 acute myeloid leukaemia [AML]) and 51 healthy child controls. Our result showed that urinary Ni in acute leukaemia patients (ALL: 68.40 ± 133.98, AML: 41.48 ± 76.31 ng/mg creatinine) was significantly higher than that in controls (62.47 ± 124.90 vs 17.63 ± 46.17 ng/mg creatinine, P < 0.05). Similarly, the pretherapy level of urinary 8-OHdG in patients (ALL: 11.83 ± 16.23, AML: 12.36 ± 11.36 ng/mg creatinine) was significantly elevated compared with controls (11.92 ± 15.42 vs 4.03 ± 4.70 ng/mg creatinine, P < 0.05). Moreover, urinary 8-OHdG and urinary Ni showed a weak but significant association with increased risk of childhood leukaemia. The present study suggests that Ni may be an etiologic factor for childhood acute leukaemia by oxidative DNA damage.


2004 ◽  
Vol 72 (4) ◽  
pp. 302-303 ◽  
Author(s):  
Pier Paolo Piccaluga ◽  
Michele Malagola ◽  
Michela Rondoni ◽  
Marilina Amabile ◽  
Stefania Paolini ◽  
...  

1997 ◽  
Vol 96 (3) ◽  
pp. 611-613 ◽  
Author(s):  
Kiyoshi Okamoto ◽  
Masamitsu Karasawa ◽  
Hirotaka Sakai ◽  
Hidemi Ogura ◽  
Kimio Morita ◽  
...  

Leukemia ◽  
2004 ◽  
Vol 19 (1) ◽  
pp. 135-135 ◽  
Author(s):  
P P Piccaluga ◽  
G Martinelli ◽  
M Malagola ◽  
M Rondoni ◽  
F Bonifazi ◽  
...  

1976 ◽  
Vol 34 (2) ◽  
pp. 167-178 ◽  
Author(s):  
M. E. J. Beard ◽  
Jill Durrant ◽  
D. Catovsky ◽  
E. Wiltshaw ◽  
J. L. Amess ◽  
...  

1989 ◽  
Vol 258 (3) ◽  
pp. 903-906 ◽  
Author(s):  
M Kundu ◽  
J Basu ◽  
P Chakrabarti ◽  
M M Rakshit

Erythrocytes from patients suffering from acute lymphoid leukaemia (ALL) show decreased proportions of spectrin tetrameters and altered spatial distribution of band 4.1 and ankyrins. These abnormalities of the cytoskeleton are probably responsible for altered membrane fluidity and transbilayer distribution of phosphatidylethanolamine in ALL. ALL is associated with severe anaemia and usually, but not always, with overproduction of lymphocytes. To our knowledge, this is the first report of abnormalities in the erythrocyte membrane in ALL which may, in part, be responsible for the observed anaemia.


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